Herbal Medicines for Asthmatic Inflammation: From Basic Researches to Clinical Applications

Liu, Fang; Xuan, Nanxia; Ying, Songmin; Li, Wen; Chen, Zhihua; Shen, Huahao

doi:10.1155/2016/6943135

Cited by 22 publications

(13 citation statements)

References 101 publications

(116 reference statements)

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“…These included Glycyrrhiza uralensis [ 7 – 24 ], Prunus armeniaca [ 25 , 26 ], Pinellia ternata [ 27 ], Asarum sieboldii [ 28 , 29 ], Pheretima aspergillum [ 30 – 37 ], Aster tataricus [ 38 , 39 ], Fritillaria cirrhosa [ 40 – 43 ], Lepidium apetalum [ 44 ], Pericarpium Citri Reticulatae [ 45 – 47 ], Cortex Mori [ 48 – 52 ], Ephedra sinica Stapf [ 53 – 56 ], Zingiber officinale Roscoe [ 57 ], Tussilago farfara [ 58 – 61 ], Platycodon grandifloras [ 62 – 65 ], Fritillaria thunbergii [ 66 , 67 ], Paeonia lactiflora [ 68 – 71 ], Magnolia officinalis [ 72 – 77 ], Bupleurum chinense [ 78 , 79 ], Scutellaria baicalensis [ 80 – 86 ], Anemarrhena Rhizoma [ 87 , 88 ], Gypsum fibrosum , Eriobotryae Folium [ 89 ], Cinnamomi Ramulus [ 90 ], Zingiberis rhizoma , Schisandra Fructus [ 91 – 93 ], and Perilla frutescens [ 94 ].…”

Section: Resultsmentioning

confidence: 99%

Systematic Review: Guideline-Based Approach for the Management of Asthma and Subtypes via Chinese Medicine

Wong

Tay

Goh

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Background. Asthma is a chronic condition that results in the inflammation and narrowing of airways, often clinically presenting as wheeze and shortness of breath. Little is known of the mechanisms of action (MOA) of herbs used to treat asthma. The aim of this study is to review existing data regarding known MOA of traditional Chinese medicine which will aid in the understanding of possible interactions between Western drugs and Chinese herbs as well as the standardization of management via a proposed guideline to improve patient safety and possible synergism in the long term. Methods. We searched through 5 databases for commonly prescribed herbs and formulas for asthma and narrowed down the search to identify the underlying MOA of individual herbs that could specifically target asthma symptoms. We included studies that stated the MOA of individual herbs when used for treating symptoms of asthma, excluding them if they are described as part of a formula. Results. A total of 26 herbs commonly prescribed for asthma with known mechanism of action were identified. Herbs used for asthma were found to have similar MOA as that for drugs. Based on existing GINA guidelines, a guideline is proposed which includes a total of 5 steps depending on the severity of asthma and the herbs’ MOA. 16 formulas were subsequently identified for the management of asthma, which consist of 12 “stand-alone” and 4 “add-on” formulas. “Stand-alone” formulas used independently for asthma generally follow the GINA guidelines but do not proceed beyond step 3. These formulas consist mainly of beta-agonist and steroid-like effects. “Add-on” formulas added as adjunct to “stand-alone” formulas, however, mainly act on T helper cells or have steroid-like effects. Conclusion. Through the understanding of MOA of herbs and their respective formulas, it will ensue greater patient safety and outcomes.

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Section: Resultsmentioning

confidence: 99%

Systematic Review: Guideline-Based Approach for the Management of Asthma and Subtypes via Chinese Medicine

Wong

Tay

Goh

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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“…Since bronchial asthma is triggered by multiple factors, the herb decoction has the potential to target different inflammatory pathways simultaneously [ 29 ]. The most abundant component of DCT is Ginkgo biloba that was previously shown to reduce epithelial thickness and the number and goblet cells in OVA-challenged mice [ 52 ].…”

Section: Discussionmentioning

confidence: 99%

Ding Chuan Tang Attenuates Airway Inflammation and Eosinophil Infiltration in Ovalbumin-Sensitized Asthmatic Mice

Liu

Chen

et al. 2021

BioMed Research International

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Asthma is a T helper 2 (Th2) cell-associated chronic inflammatory diseases characterized with airway obstruction, increased mucus production, and eosinophil infiltration. Conventional medications for asthma treatment cannot fully control the symptoms, and potential side effects are also the concerns. Thus, complement or alternative medicine (CAM) became a new option for asthma management. Ding Chuan Tang (DCT) is a traditional Chinese herbal decoction applied mainly for patients with coughing, wheezing, chest tightness, and asthma. Previously, DCT has been proved to improve children airway hyperresponsiveness (AHR) in a randomized and double-blind clinical trial. However, the mechanisms of how DCT alleviates AHR remain unclear. Since asthmatic features such as eosinophil infiltration, IgE production, and mucus accumulation are relative with Th2 responses, we hypothesized that DCT may attenuate asthma symptoms through regulating Th2 cells. Ovalbumin (OVA) was used as a stimulant to sensitize BALB/c mice to establish an asthmatic model. AHR was detected one day before sacrifice. BALF and serum were collected for immune cell counting and antibody analysis. Splenocytes were cultured with OVA in order to determine Th2 cytokine production. Lung tissues were collected for histological and gene expression analyses. Our data reveal that DCT can attenuate AHR and eosinophil accumulation in the 30-day sensitization asthmatic model. Histological results demonstrated that DCT can reduce cell infiltration and mucus production in peribronchial and perivascular site. In OVA-stimulated splenocyte cultures, a significant reduction of IL-5 and IL-13 in DCT-treated mice suggests that DCT may alleviate Th2 responses. In conclusion, the current study demonstrates that DCT has the potential to suppress allergic responses through the reduction of mucus production, eosinophil infiltration, and Th2 activity in asthma.

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“…Previous studies reported that some secondary compounds in plants can attenuate AHR, eosinophil infiltration, and immunoregulatory effects in asthmatic mice [ 24 , 25 ]. Anthocyanidins, flavonols (quercetin and kaempferol), flavones (apigenin and luteolin), and isoflavones (genistein) have been reported to ameliorate airway remodeling and the inflammatory response in mice [ 26 , 27 ].…”

Section: Discussionmentioning

confidence: 99%

Tomatidine Attenuates Airway Hyperresponsiveness and Inflammation by Suppressing Th2 Cytokines in a Mouse Model of Asthma

Kuo

Huang

Liou

et al. 2017

Mediators of Inflammation

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Tomatidine is isolated from the fruits of tomato plants and found to have anti-inflammatory effects in macrophages. In the present study, we investigated whether tomatidine suppresses airway hyperresponsiveness (AHR) and eosinophil infiltration in asthmatic mice. BALB/c mice were sensitized with ovalbumin and treated with tomatidine by intraperitoneal injection. Airway resistance was measured by intubation analysis as an indication of airway responsiveness, and histological studies were performed to evaluate eosinophil infiltration in lung tissue. Tomatidine reduced AHR and decreased eosinophil infiltration in the lungs of asthmatic mice. Tomatidine suppressed Th2 cytokine production in bronchoalveolar lavage fluid. Tomatidine also blocked the expression of inflammatory and Th2 cytokine genes in lung tissue. In vitro, tomatidine inhibited proinflammatory cytokines and CCL11 production in inflammatory BEAS-2B bronchial epithelial cells. These results indicate that tomatidine contributes to the amelioration of AHR and eosinophil infiltration by blocking the inflammatory response and Th2 cell activity in asthmatic mice.

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Herbal Medicines for Asthmatic Inflammation: From Basic Researches to Clinical Applications

Cited by 22 publications

References 101 publications

Systematic Review: Guideline-Based Approach for the Management of Asthma and Subtypes via Chinese Medicine

Systematic Review: Guideline-Based Approach for the Management of Asthma and Subtypes via Chinese Medicine

Ding Chuan Tang Attenuates Airway Inflammation and Eosinophil Infiltration in Ovalbumin-Sensitized Asthmatic Mice

Tomatidine Attenuates Airway Hyperresponsiveness and Inflammation by Suppressing Th2 Cytokines in a Mouse Model of Asthma

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