Anti-inflammatory Effects of Aroma Oil Complex on DNCB-Induced Allergic Contact Dermatitis in Dogs

Oh, Dongkyu; Oh, Tae-Ho

doi:10.17555/ksvc.2014.06.31.3.180

Cited by 1 publication

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The oral administration of Lactobacillus brevis reduces IFN-γ production in mice affected by experimentally induced dermatitis with picryl chloride (Segawa et al, 2008). Kim et al (2012)…”

Section: Discussionmentioning

confidence: 99%

“…As there were few studies on the development of contact dermatitis in dogs, these reactions were optimized in mice and dogs (Zayerzadeh et al., 2020). The 5% and 10% DNCB solutions caused more severe lesions and are not suitable for inducing contact dermatitis‐like lesions in dogs (Krawiec & Ghaafar, 1975 ; Kim et al., 2012 ).…”

Section: Discussionmentioning

confidence: 99%

“…Kim et al. ( 2012 ) administered poly‐gamma glutamic acid obtained from B. subtilis to dogs with DNCB‐induced dermatitis. This treatment significantly reduced IFN‐γ‐producing cells in the skin.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Effect of Bacillus subtilis and Bacillus coagulans spores on induced allergic contact dermatitis in dogs

Khosravi,

Avizeh,

Zayerzadeh

et al. 2024

Veterinary Medicine & Sci

View full text Add to dashboard Cite

BackgroundProbiotic strains have the potential to modulate immune responses, reduce intestinal inflammation, normalize intestinal mucosal function and decrease allergic reactions.ObjectiveThis study aimed to investigate the effect of oral probiotic supplements containing Bacillus subtilis and Bacillus coagulans spores on clinical symptoms, haematological factors and immune responses to allergic contact dermatitis in dogs induced by dinitrochlorobenzene (DNCB).MethodsDNCB was injected subcutaneously into the scapular region of 20 healthy adult dogs of both sexes, divided into four groups, to induce experimental allergic contact dermatitis. Dogs in Group 1 received food without probiotics or medication. Oral prednisolone was administered to Group 2 for 30 days at a dosage of 0.25 mg/kg every other day. The dogs in Group 3 were treated with a combination of oral prednisolone and probiotics. The dogs in Group 4 were fed daily with a mixture of 109 B. subtilis and B. coagulans bacteria for 30 days. The immune system responses and related gene expression were analysed in the treated animals.ResultsThe administration of probiotics for 30 days resulted in a reduction in clinical symptoms and duration of wound repair. The probiotics treatment also significantly increased the serum bactericidal effects against Staphylococcus aureus and Escherichia coli. It enhanced both the classic and alternative activity of the complement, as well as lysozyme activity. Additionally, the probiotics led to higher total immunoglobulin levels and significant reductions in anti‐trypsin and C‐reactive protein levels. Furthermore, the expression of IgE, induction of interferon‐gamma and IL‐4 genes were also reduced.ConclusionsAccording to the results, B. subtilis and B. coagulans can be further investigated as a viable alternative to corticosteroids in treating allergic contact dermatitis in dogs.

show abstract

“…The oral administration of Lactobacillus brevis reduces IFN-γ production in mice affected by experimentally induced dermatitis with picryl chloride (Segawa et al, 2008). Kim et al (2012)…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%