Anti-inflammatory effect of the methanol, ethyl acetate and chloroform extracts of Tragopogon porrifolius aerial parts

Hariri, Essa; Asmar, Meena; Demirdjian, SA; Daher, CF; Mroueh, Mohammad

doi:10.1055/s-0033-1352410

Cited by 6 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recent studies in our laboratory revealed that intake of aqueous extract of T. porrifolius caused improvement of lipemia and increased satiety in rats with no visible adverse effects [ 10 ]. Additionally, methanol, ethyl acetate, and chloroform extracts of aerial parts of T. porrifolius demonstrated anti-inflammatory effects in mice [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Hepatoprotective, Antioxidant, and Anticancer Effects of theTragopogon porrifoliusMethanolic Extract

Tenkerian

El‐Sibai

Daher

et al. 2015

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Tragopogon porrifolius (Asteraceae), commonly referred to as white salsify, is an edible herb used in Lebanese folk medicine to treat cancer and liver dysfunction. In this study, we investigated the antioxidant activity of Tragopogon porrifolius methanolic extract, both in vitro and in vivo, in addition to its hepatoprotective and anticancer activities. Total phenolic and flavonoid contents were measured and found to be 37.0 ± 1.40 mg GAE/g and 16.6 ± 0.42 mg QE/g dry weight, respectively. In vitro antioxidant assays revealed an FRAP value of 659 ± 13.8 µmol Fe2+/g of extract and DPPH IC50 value 15.2 µg/mL. In rats subjected to CCl4-induced hepatotoxicity, significant increase in CAT, SOD, and GST levels was detected. The highest dose of the extract (250 mg/kg) recorded a fold increase of 1.68 for SOD, 2.49 for GST, and 3.2 for CAT. The extract also showed substantial decrease in AST (57%), ALT (56%), and LDH (65%) levels. Additionally, the extract caused a dose-dependent decrease in cell viability and proliferation. In conclusion, the methanolic extract of T. porrifolius displayed a relatively high antioxidant activity both in vitro and in vivo as well as hepatoprotective potential against liver toxicity in rats and anticancer effect on MDA-MB-231 and Caco-2 cells.

show abstract

Section: Introductionmentioning

confidence: 99%

Hepatoprotective, Antioxidant, and Anticancer Effects of theTragopogon porrifoliusMethanolic Extract

Tenkerian

El‐Sibai

Daher

et al. 2015

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

“…ethanol [29], hexane [22], chloroform [70], and water [27]. The contents of each extraction method can vary, and this can determine the effect of the plant.…”

Section: Discussionmentioning

confidence: 99%

Phytochemical Composition, Antimicrobial, Anticancer Properties and Molecular Docking Profiles of Tragopogon coelesyriacus Boiss. Extracts

Unver,

Uzuner,

Celik-Uzuner

et al. 2023

Preprint

View full text Add to dashboard Cite

Tragopogon coelesyriacus is a biennial herbaceous plant of the Asteraceae family that grows mainly in Europe and Asia and is consumed as a vegetable in Turkey. This study aimed to obtain methanol and water extracts from aerial parts (stem, leaf, and flower) of the T. coelesyriacus to determine its phenolic compounds and subsequently to determine the antimicrobial and anticancer activities of T. coelesyriacus extracts as well as in silico molecular docking profiles for targets. T. coelesyriacus methanol extract had a higher inhibitory effect against S. aureus, P. aeruginosa, and K. pneumonia (MIC: 0.83, 1.67 and 1.67 mg/mL, respectively) than E. coli and E. aerogenes (MIC: 53.3 mg/mL). Antifungal activity was observed against all Candida species, with the highest inhibition against C. krusei (MIC: 0.83 mg/mL). In contrast, T. coelesyriacus water extract had no inhibitory effect. Furthermore, both extracts of T. coelesyriacus showed a significant cytotoxic effect on AR42J pancreatic cancer cells. However, HeLa cervical and MDA-MB-231 breast cancer cells were more resistant to the cytotoxic effect of methanol and water extract, respectively. In silico analyses showed the inhibitory effects of Keracyanin chloride within the extracts on S. aureus MurB protein and the remarkable inhibitory potential of the Naringin molecule on FYN kinase protein regarding AR42J pancreatic cells. This study is the first in vitro and in silico analysis to show T. coelesyriacus antimicrobial and anticancer effects along with molecular docking profiles, and it suggests that T. coelesyriacus can be used as a potent pharmacological and therapeutic-protective agent.

show abstract

“…The methanol extract exhibited maximum anti-inflammatory activity. b-Amyrin acetate has been demonstrated to be responsible for its anti-inflammatory effect [98].…”

Section: Solanum Nigrum Lmentioning

confidence: 99%

Scientific evaluation of medicinal plants used for the treatment of abnormal uterine bleeding by Avicenna

Mobli

Qaraaty

Amin

et al. 2015

Arch Gynecol Obstet

View full text Add to dashboard Cite

show abstract

Anti-inflammatory effect of the methanol, ethyl acetate and chloroform extracts of Tragopogon porrifolius aerial parts

Cited by 6 publications

References 0 publications

Hepatoprotective, Antioxidant, and Anticancer Effects of theTragopogon porrifoliusMethanolic Extract

Hepatoprotective, Antioxidant, and Anticancer Effects of theTragopogon porrifoliusMethanolic Extract

Phytochemical Composition, Antimicrobial, Anticancer Properties and Molecular Docking Profiles of Tragopogon coelesyriacus Boiss. Extracts

Scientific evaluation of medicinal plants used for the treatment of abnormal uterine bleeding by Avicenna

Contact Info

Product

Resources

About