Anti-inflammatory effect of Rosa laevigata extract on in vitro and in vivo model of allergic asthma via the suppression of IgE and related cytokines

Effect of Rosa laevigata on PM10-Induced Inflammatory Response of Human Lung Epithelial Cells

“…RL we used in this study was a medicinal herb used in previous experiments, and the compounds related to anti-inflammatory effects such as quercetin and epicatechin were identified by LC-MS analysis [ 18 ]. In addition, RL contains flavonoids such as apigenin and kaempferide, as well as saponins such as ursolic acid, oleanolic acid, and β -sitosterol [ 38 ].…”

“…RL extract preparation and UPLC/ESI-QTOF-MS analysis have been described in our previous study [ 18 ]. Briefly, RL was extracted with distilled water for 3 h at 100°C.…”

“…A recent pharmacological study of RL has suggested that relief from various diseases including the function of flavonoids in relieving oxidative stress, inflammation, and apoptosis and total saponins in RL protect against liver disease caused by carbon tetrachloride [ 15 – 17 ]. However, the anti-inflammatory effect on epithelial cells in the lungs related to allergic asthma is the only study in our epidermal growth factor- (EGF-) induced inflammation model [ 18 ]. Therefore, in the present study, we investigated the mechanism through which PM10 causes inflammatory responses in pulmonary epithelial cells.…”

A Review on the Phytochemical and Pharmacological Properties of <i>Rosa laevigata</i>: A Medicinal and Edible Plant

“…In the anti-inflammatory study of R. laevigata, triterpenoids have received the most attention and their anti-inflammatory mechanism can mainly be attributed to inhibit the abnormal activation of NF-κB signalling pathway caused by lipopolysaccharide (LPS) and other stimulants. 8,37,38) Taking compound 21 as an instance, it exhibited moderate inhibitory activity on the release of tumour necrosis factor-alpha (TNF-α), Interleukin (IL)-1β, IL-6, and IL-10 with IC 50 values of 14.32, 8.53, 8.04, and 10.38 µM, respectively, while the IC 50 value was measured as 23.21 µM for the inhibition on NF-κB transcriptional activity. In addition, the triterpenoids derivatives from the fruit of R. laevigata var.…”

“…49) In addition to TFs, RLTS could also protect the liver injury induced by CCl 4 through a similar mechanism of action. 38,50,51) Moreover, RLTS exerted anti-fibrotic effects via regulating the signalling pathways of transforming growth factor-β (TGFβ)/mothers against DPP homolog (Smad), focal adhesion kinase 1 (FAK)-phosphoinositide 3-kinase (PI3K)protein kinase B (Akt)-p70S6 Kinase (p70S6K) and MAPKs. Further research also indicated that the realization of RLTS in matrix degradation could be attributed to down-regulation of matrix metalloproteinases (MMPs).…”