A Review on the Phytochemical and Pharmacological Properties of &lt;i&gt;Rosa laevigata&lt;/i&gt;: A Medicinal and Edible Plant

Li, Bailin; Yuan, Jie; Wu, Jiunn‐Tzong

doi:10.1248/cpb.c20-00743

Cited by 12 publications

(8 citation statements)

References 55 publications

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“…Studies have shown that Fructus R. laevigata is rich in total flavonoids (TFs), a component that is closely associated with antioxidant activity. This suggests that TFs in R. laevigata may be a rich source of natural antioxidants for the prevention and treatment of diseases caused by oxidative stress such as cardiovascular disease ( Li et al, 2021 ). Liu et al (2010b) found that TFs of Fructus R. laevigata have a scavenging effect on 2,2-diphenyl-1-picrylhydrazyl (DPPH), hydroxyl and superoxide anion radicals and they have a strong reducing ability.…”

Section: Pharmacologymentioning

confidence: 99%

Traditional uses, phytochemical, pharmacology, quality control and modern applications of two important Chinese medicines from Rosa laevigata Michx.: A review

Quan

Huang²,

Chen³

2022

Front. Pharmacol.

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Rosa laevigata Michx. is an ethnic medicine that have strong biological activities used in the traditional medicine system for the treatment of diabetes, nephropathy, myocardial damage, oxidative damage, liver damage and so on. Currently, The Chinese herb R. laevigata Michx. can be divided into two important medicines: Fructus R. laevigata and Radix R. laevigata, from which approximately 148 chemical components have been isolated, including flavonoids, lignans, polyphenols, steroids, triterpenoids, tannins as well as other components. Pharmacological studies have already confirmed that both of these herbs have antioxidant, anti-inflammatory, antiviral and anti-tumor activities, as well as renal protective, immunomodulatory, lipid-lowering, cardiovascular protective, bacteriostatic, and other pharmacological effects. Toxicological tests and quality control studies revealed the safety and nontoxicity of R. laevigata Michx. Therefore, this paper systematically summarizes the traditional uses, botanical, phytochemical, and pharmacology as well as the quality control and toxicology of Fructus and Radix, which in order to provide a comprehensive reference for its continued research.

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Section: Pharmacologymentioning

confidence: 99%

Traditional uses, phytochemical, pharmacology, quality control and modern applications of two important Chinese medicines from Rosa laevigata Michx.: A review

Quan

Huang²,

Chen³

2022

Front. Pharmacol.

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“…R. laevigata is recognized as a health food resource by the Chinese Ministry of Health, and served as a medicine for the spleen and for relieving diarrhea in Traditional Chinese Medicine (TCM) approximately 1000 years ago. Pharmacological studies have demonstrated that R. laevigata possesses excellent medicinal value, which is characterized by its antioxidant, hypolipidemic, and anti-inflammatory effects [2]. Its primary components include polysaccharides, triterpenoid acids, vitamin C, steroids, polyphenols, and saponins.…”

Section: Introductionmentioning

confidence: 99%

Structural Characterization and In Vitro Anti-Inflammatory Activity of Polysaccharides Isolated from the Fruits of Rosa laevigata

Peng,

Gu,

Mao

et al. 2024

IJMS

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RLPa-2 (Mw 15.6 kDa) is a polysaccharide isolated from Rosa laevigata Michx. It consists of arabinose (Ara), galactose (Gal), rhamnose (Rha), glucose (Glc), xylose (Xyl), and galacturonic acid (Gal-UA) with a molar ratio of 1.00:0.91:0.39:0.34:0.25:0.20. Structural characterization was performed by methylation and NMR analysis, which indicated that RLPa-2 might comprise →6)-α-D-Galp-(1→, →4)-α-D-GalpA-(1→, α-L-Araf-(1→, →2,4)-α-D-Glcp-(1→, β-D-Xylp, and α-L-Rhap. In addition, the bioactivity of RLPa-2 was assessed through an in vitro macrophage polarization assay. Compared to positive controls, there was a significant decrease in the expression of M1 macrophage markers (CD80, CD86) and p-STAT3/STAT3 protein. Additionally, there was a down-regulation in the production of pro-inflammatory mediators (NO, IL-6, TNF-α), indicating that M1 macrophage polarization induced with lipopolysaccharide (LPS) and interferon-γ (IFN-γ) stimulation could be inhibited by RLPa-2. These findings demonstrate that the RLPa-2 might be considered as a potential anti-inflammatory drug to reduce inflammation.

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“…Rosa laevigata Michx., unique to China, commonly known as the “Jin-Ying-Zi” in Chinese, is an evergreen climbing shrub prevalent in the southern regions of China. Its fruits were documented in the Chinese Pharmacopoeia and are mainly used for the treatment of nocturnal emission, nocturnal enuresis, frequent urination, metrorrhagia, and diarrhea [ 12 ]. Moreover, as a recognized functional and health food in Asian countries, the fruit of R. laevigata (RLM-F) has been developed as a third-generation wild fruit by the Ministry of National Health of China [ 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

UPLC-ESI-MS/MS-Based Analysis of Various Edible Rosa Fruits Concerning Secondary Metabolites and Evaluation of Their Antioxidant Activities

Ni,

Chen,

et al. 2024

Foods

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The genus Rosa is globally popular with well-established applications since it has a high edible and medicinal value. However, relatively limited research has been conducted on the composition and quality of wild Rosa fruits. The present study aimed to compare the properties and chemical components of five wild edible Rosa fruits, Rosa roxburghii, Rosa sterilis, Rosa laevigata, Rosa davurica, and Rosa sericea. The UPLC-ESI-MS/MS approach identified the key metabolites among the five Rosa fruits as flavonoids, phenolic acids, and organic acids. The main differential metabolites among the five fruits are flavonoids (22.29–45.13%), phenolic acids (17–22.27%), and terpenoids (7.7–24%), respectively. In total, 125 compounds served as potential markers for the five Rosa species. Differential metabolic pathways of five Rosa fruits were analyzed using the KEGG approach. Rosa laevigata fruits showed the highest total polysaccharide (TPS) content of 64.48 g/100 g. All the five Rosa extracts effectively decreased the levels of malondialdehyde while increasing the activities of superoxide dismutase and glutathione peroxidase in the H2O2-induced HaCaT cell model, demonstrating high potential for antioxidant development. Our findings suggest that the five studied Rosa fruits exhibit biological activity and edible value worth further exploration.

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A Review on the Phytochemical and Pharmacological Properties of <i>Rosa laevigata</i>: A Medicinal and Edible Plant

Cited by 12 publications

References 55 publications

Traditional uses, phytochemical, pharmacology, quality control and modern applications of two important Chinese medicines from Rosa laevigata Michx.: A review

Traditional uses, phytochemical, pharmacology, quality control and modern applications of two important Chinese medicines from Rosa laevigata Michx.: A review

Structural Characterization and In Vitro Anti-Inflammatory Activity of Polysaccharides Isolated from the Fruits of Rosa laevigata

UPLC-ESI-MS/MS-Based Analysis of Various Edible Rosa Fruits Concerning Secondary Metabolites and Evaluation of Their Antioxidant Activities

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