Anti-Inflammatory Effect of Peel Extracts from Citrus Fruits

Lee, Sook-Hyun; Suh, Sungho; Lee, Kyoung-Hae; Yang, Jong-Beom; Choi, Sung-Up

doi:10.13103/jfhs.2013.28.4.342

Cited by 5 publications

(5 citation statements)

References 29 publications

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“…Due to the side effects of synthetic antioxidants, products having a natural origin are actively made. As interest in natural products has increased, the use of natural plant materials in functional cosmetics is also increasing [ 23 , 24 , 25 ].…”

Section: Discussionmentioning

confidence: 99%

Antioxidant, Whitening, Antiwrinkle, and Anti-Inflammatory Effect of Ajuga spectabilis Nakai Extract

Lee¹,

Oh²,

Kim³

et al. 2022

Plants

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Since ancient times, plants have been a good source of natural antioxidants. Plants remove active oxygen through antioxidants and contain various active ingredients. These active ingredients of plants are used to alleviate skin aging and chronic diseases. Ajuga spectabilis Nakai (AS) is a perennial plant, is endemic to Korea, and has the characteristics of alpine plants. The aim of this study was to assure the possibility of using AS as a functional natural and cosmetic material. For this, we carried out biologically activated material characteristic evaluations about antioxidant, wrinkle reduction, and anti-inflammatory effects using AS extract. To carry out this experiment, we extracted AS extract from AS water extract (AS-W) and AS 70% ethanol extract (AS-E). AS-E showed the highest DPPH activity and tyrosinase inhibitory activity. After, the measurement of metalloprotease (MMP)-1 inhibition effect showed the AS-W and AS-E activation at the concentration of 100 µg/mL. In addition, at the same concentration, from the result of the measurement of the biosynthesis quantity of pro-collagen type-1 we knew that its excellent effect appeared in AS-E (CCD-986sk). The inhibition of NO production in AS-W and AS-E was confirmed in LPS-induced mouse macrophage RAW264.7 cells. On cell viability, it was judged that AS-E had no toxicity because it showed a high cell viability at a high concentration, and it was used for the anti-inflammatory activity. Inhibition of NO production worked only in AS-E; inflammatory cytokine TNF-α and IL-6 were suppressed in a concentration-dependent manner in AS-E. AS is believed to be used as a natural cosmetic material because it has been proven to have antioxidant, whitening, wrinkle-improving, and anti-inflammatory effects. Therefore, the results indicate that AS extract can play an important role as a functional natural material and a cosmetic material for whitening, wrinkle reduction, and anti-inflammatory effect.

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Section: Discussionmentioning

confidence: 99%

Antioxidant, Whitening, Antiwrinkle, and Anti-Inflammatory Effect of Ajuga spectabilis Nakai Extract

Lee¹,

Oh²,

Kim³

et al. 2022

Plants

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“…Although previous limited findings have revealed that Hallabong peel extracts show antiinflammatory effects in RAW 264.7 macrophage cells (Lee et al 2013), the topical application of Hallabong fruit extracts has been rarely investigated as an anti-inflammatory mediator. Here, we investigated the potent inhibitory effect of topically applied HE on TPA-produced mouse ear oedema model and anti-inflammatory effect of HE on splenocytes.…”

Section: Discussionmentioning

confidence: 99%

Citrus hallabong [(Citrus unshiu × C. sinensis) × C. reticulata)] exerts potent anti-inflammatory properties in murine splenocytes and TPA-induced murine ear oedema model

Herath

Bing

Cho

et al. 2016

Pharmaceutical Biology

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þ memory T-cell population, an important marker for anti-inflammatory activity, and a significant inhibition in the production of IL-2 and IFN-c. HE treatment had reduced the mouse skin oedema (47%) and myeloperoxidase (MPO) activity significantly (40%) in TPA-challenged tissues. More importantly, immunohistochemical localization revealed the suppressed (p < 0.05) expression of inducible nitric oxide (iNOS), cyclooxygenase-2 (COX2). HE decreased the infiltration of CD3 þ T cells and F4/80 þ macrophages to the site of inflammation and a topical application of HE significantly suppressed the expression of TNF-a (20.2%). Discussion and conclusion: A topical application of HE can exert a potential anti-inflammatory effect and HE can be explored further as a putative alternative therapeutic agent for inflammatory oedema. ARTICLE HISTORY

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“…Dried peel of Citrus unshiu Markov has been traditionally used as a popular herbal ingredient for treatment of various digestive dysfunctions, including abdominal distension, nausea, vomiting, and dyspepsia in East Asia such as Korea and Japan [ 14 ]. Based on its excellent properties and safe use, this herb has been commonly used for a long time in food or medicine preparation which was registered and managed as policy documents of Korea Food and Drug Administration [ 15 , 16 ]. The dried peel of Citrus unshiu , like other citrus species, has been experimentally proven to be able to ameliorate hyperglycemia through inhibition of hepatic gluconeogenic enzyme and induction of insulin/glucagon secretion.…”

Section: Introductionmentioning

confidence: 99%

Clinical Investigations of the Effect of Citrus unshiu Peel Pellet on Obesity and Lipid Profile

Kang¹,

Song²,

Lee³

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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Objectives Several experimental studies have reported antiobesity and lipid-improving effects of Citrus unshiu. However, clinical studies on its effects are lacking. This study was designed to evaluate the impact of Citrus unshiu peel pellet (CUPP) on obesity and lipid profile. Methods For 118 patients with body mass index (BMI) > 23 who took Citrus unshiu peel pellet (CUPP) for 4 weeks in a Public Health Center, laboratory and biometric readings before and after CUPP administration were analyzed. Results Mean age of these subjects was 53.8±10.6 years (range: 18-75 years). There were 88 (74.6%) females in the study sample (n = 118). A significant (p < 0.01) decrease in BMI from 27.47±2.24 to 27.27±2.22 was observed in all subjects after CUPP treatment and 65.3% (N = 77) of them lost 1.03±0.83 kg of weight after 4 weeks of treatment. Total cholesterol level was significantly (p < 0.01) decreased from 204.0±37.4 mg/dL to 193.5±36.5 mg/dL. Significant (p < 0.05) decreases in levels of low-density lipoprotein, cholesterol, and triglyceride were also observed. Conclusions These results suggest that CUPP in practice could help weight control and improve total cholesterol level. Findings of this study provide clinical foundation for future large-scale trials to establish clinical benefits of CUPP.

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Anti-Inflammatory Effect of Peel Extracts from Citrus Fruits

Cited by 5 publications

References 29 publications

Antioxidant, Whitening, Antiwrinkle, and Anti-Inflammatory Effect of Ajuga spectabilis Nakai Extract

Antioxidant, Whitening, Antiwrinkle, and Anti-Inflammatory Effect of Ajuga spectabilis Nakai Extract

Citrus hallabong [(Citrus unshiu × C. sinensis) × C. reticulata)] exerts potent anti-inflammatory properties in murine splenocytes and TPA-induced murine ear oedema model

Clinical Investigations of the Effect of Citrus unshiu Peel Pellet on Obesity and Lipid Profile

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