Citrus hallabong [(Citrus unshiu × C. sinensis) × C. reticulata)] exerts potent anti-inflammatory properties in murine splenocytes and TPA-induced murine ear oedema model

Abstract

þ memory T-cell population, an important marker for anti-inflammatory activity, and a significant inhibition in the production of IL-2 and IFN-c. HE treatment had reduced the mouse skin oedema (47%) and myeloperoxidase (MPO) activity significantly (40%) in TPA-challenged tissues. More importantly, immunohistochemical localization revealed the suppressed (p < 0.05) expression of inducible nitric oxide (iNOS), cyclooxygenase-2 (COX2). HE decreased the infiltration of CD3 þ T cells and F4/80 þ macrophages to the site of inflammation and a topical application of HE significantly suppressed the expression of TNF-a (20.2%). Discussion and conclusion: A topical application of HE can exert a potential anti-inflammatory effect and HE can be explored further as a putative alternative therapeutic agent for inflammatory oedema. ARTICLE HISTORY

Network Pharmacology-Based Validation of the Efficacy of Huiyangjiuji Decoction in the Treatment of Experimental Colitis

“…In the context of SI-NI decoction, the anti-inflammatory function has been emphasized by the addition of PGM (Jin et al, 2020), PB (Tian et al, 2020), SCF (Panossian & Wikman, 2008;Li et al, 2020;Li et al, 2021), PCW as well as CC (Csikos et al, 2020). Moreover, focusing on the impaired gastrointestinal functions, AMK is included to improve gastrointestinal motility (Zhu et al, 2018;Yang et al, 2019) and restore immune homeostasis (Xiang et al, 2020), while CR maintains homeostasis of the gut microbiota (Chen et al, 2020) and inhibits inflammation (Ho & Lin, 2008;Herath et al, 2016). Combining various anti-inflammatory herbs with gutfriendly components has offered a promising therapeutic alternative for gut diseases, especially for UC and UC-CRC.…”

Compositional characteristics and antibacterial activity of essential oils in citrus hybrid peels

“…The essential oil composition of Hallabong peel in the previous study was similar to that in this study. Hallabong peel essential oil has been reported to have antioxidant activity against DPPH radicals and anti-inflammatory activity against splenocytes and edema in rats and macrophages (Herath et al, 2016). The activity of Hallabong peel essential oil is thought to be due to several active components constituting the essential oil.…”