Anti-inflammatory effect of novel andrographolide derivatives through inhibition of NO and PGE2 production

Anti-Inflammatory Effect of Procyanidins from Wild Grape (Vitis amurensis) Seeds in LPS-Induced RAW 264.7 Cells

“…COX-2 is another inducible enzyme that catalyzes biosynthesis of PGE 2 , which contributes to pathogenesis of various inflammatory diseases, edema, angiogenesis, invasion, and growth of tumor [41]. Recently, mounting evidence both in vitro and in vivo has indicated an existing cross-talk between the release of NO and PGE 2 in the modulation of molecular mechanisms that regulate inflammation pathway [42, 43]. Thus, the anti-inflammatory agents that decrease NO and PGs production by simultaneously inhibiting the iNOS and COX-2 gene may have a potential therapeutic effect on the treatment of inflammatory and infectious diseases.…”

Anti-cell Proliferative and Anti-angiogenic Potential of Andrographolide During 7,12-Dimethylbenz(a)anthracene Induced Hamster Buccal Pouch Carcinogenesis

“…Andrographolide, a major active constituent of Andrographis paniculata, exhibited diverse biochemical and pharmacological properties including antiinflammatory, antihyperglycemic, hepatoprotective, antioxidant and anticancer properties (Trivedi et al, 2007;Dai et al, 2011). Wang et al (2011) reported that andrographolide suppressed oral tumors through NFkB inactivation.…”

Water-soluble andrographolide sulfonate exerts anti-sepsis action in mice through down-regulating p38 MAPK, STAT3 and NF-κB pathways

“…It has been reported that andrographolide possesses antibacterial, anti-inflammatory, antiviral, hepatoprotective, neuronprotective, antiangiogenic and anti-tumor activities [6][7][8][9][10][11][12][13][14][15]. Now it is an approved drug mainly used for treatment of various ailments including respiratory infection, bacterial dysentery and fever in China.…”