Anti-Inflammatory Effect of Lycopene on Experimental Spinal Cord Ischemia Injury via Cyclooxygenase-2 Suppression

Ye, Hua; Xu, Nanfei; Ma, Tao; Liu, Yumin; Xu, Hong; Lu, Yunnan

doi:10.1159/000495466

Cited by 22 publications

(12 citation statements)

References 34 publications

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“…Similar inhibition of NF-κB has been reported for beta-carotene in a rat model of SCI [67]. In particular, astaxanthin, crocetin, and lycopene decreased pain [68][69][70][71][72]. Moreover, astaxanthin [71], crocetin [73] and crocin improved locomotor function [74].…”

Section: Dietary Antioxidants In Spinal Cord Injurysupporting

confidence: 68%

Hormetic Effects of Bioactive Compounds from Foods, Beverages, and Food Dressing: The Potential Role in Spinal Cord Injury

Fedullo

Ciccotti²,

Giannotta³

et al. 2021

Oxidative Medicine and Cellular Longevity

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Spinal cord injury (SCI) is a damage or trauma to the spinal cord resulting in a total or partial loss of motor and sensory function. SCI is characterized by a disequilibrium between the production of reactive oxygen species and the levels of antioxidant defences, causing oxidative stress and neuroinflammation. This review is aimed at highlighting the hormetic effects of some compounds from foods, beverages, and food dressing that are able to reduce oxidative stress in patients with SCI. Although curcumin, ginseng, and green tea have been proposed for SCI management, low levels of antioxidant vitamins have been reported in individuals with SCI. Mediterranean diet includes food rich in vitamins and antioxidants. Moreover, food dressing, including spices, herbs, and extra virgin olive oil (EVOO), contains multiple components with hormetic effects. The latter involves the activation of the nuclear factor erythroid-derived 2, consequently increasing the antioxidant enzymes and decreasing inflammation. Furthermore, EVOO improves the bioavailability of carotenoids and could be a delivery system for bioactive compounds. In conclusion, Mediterranean dressing in addition to plant foods can have an important effect on redox balance in individuals with SCI.

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Section: Dietary Antioxidants In Spinal Cord Injurysupporting

confidence: 68%

Hormetic Effects of Bioactive Compounds from Foods, Beverages, and Food Dressing: The Potential Role in Spinal Cord Injury

Fedullo

Ciccotti²,

Giannotta³

et al. 2021

Oxidative Medicine and Cellular Longevity

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show abstract

“…In an experimental study conducted by Hua et al, [35] spinal cord ischemia was induced by cyclooxygenase-2 (cox-2) suppression. Lycopene was administered for 14 days following cox-2 suppression.…”

Section: Discussionmentioning

confidence: 99%

The Protective Effect of Lycopene on Ischemia/Reperfusion Injury in Rat Hind Limb Muscle Model

Kirişçi

Guneri

Seyithanoğlu

et al. 2020

Ulus Travma Acil Cerrahi Derg

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BACKGROUND: Acute ischemia/reperfusion (I/R) injury of skeletal muscle, an important mortality and morbidity cause, is associated with oxidative stress. Lycopene is a carotenoid pigment with potent antioxidant activity and is found in vegetables and fruits. This study aims to investigate the protective effects of lycopene against I/R injury in rat hind limb muscle model. METHODS:Thirty-two Wistar-albino rats were randomly allocated to control, lycopene, I/R and I/R+lycopene groups. In lycopene and I/R+lycopene groups, the rats received 10 mg/kg/day lycopene orally for 15 days before the experiment. Dissection around abdominal aorta at the infrarenal level was performed in all rats under general anesthesia. The aorta was clamped at the infrarenal level in the I/R and I/R+lycopene groups for two hours. Then, reperfusion was allowed for two hours in these groups. Samples were obtained from the hind limb muscles of rats after sacrifice for biochemical and histopathological analyses. RESULTS:Serum and tissue malondialdehyde and ischemia-modified albumin levels were significantly lower in the I/R+lycopene group compared to I/R group (p<0.001). Serum glutathione peroxidase (GSH-Px) levels were significantly lower in the I/R group compared to those in control and I/R+lycopene groups (p<0.05). Tissue GSH-Px levels were significantly lower in the I/R group compared to the Lycopene group (p=0.003). Serum superoxide dismutase (SOD) levels were significantly lower in the I/R group compared to three groups (p<0.001). Tissue SOD levels were significantly lower in the I/R group compared to those in control and Lycopene groups (p=0.005). Histopathological assessments revealed that inflammatory changes following I/R injury were significantly reduced in the I/ R+lycopene group. CONCLUSION:The findings obtained in this study show lycopene's cytoprotective activity against I/R injury in rat skeletal muscle model.

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“…Furthermore, lycopene exhibited neuroprotective effects in MPTP-treated PD mice models by increasing dopamine levels and decreasing oxidative stress levels [198]. Lycopene has also proved to be useful in spinal cord ischemia/reperfusion injury rat models, by improving neurological function recovery and suppressing neuronal death and neuroinflammation [199] and hyperlipidemia-induced cerebral vessel injury prevention by decreasing astrocytes activation and inflammatory cytokine production [200].…”

Section: Marine Pigments For Neuroprotectionmentioning

confidence: 99%

Marine Biocompounds for Neuroprotection—A Review

2020

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While terrestrial organisms are the primary source of natural products, recent years have witnessed a considerable shift towards marine-sourced biocompounds. They have achieved a great scientific interest due to the plethora of compounds with structural and chemical properties generally not found in terrestrial products, exhibiting significant bioactivity ten times higher than terrestrial-sourced molecules. In addition to the antioxidant, anti-thrombotic, anti-coagulant, anti-inflammatory, anti-proliferative, anti-hypertensive, anti-diabetic, and cardio-protection properties, marine-sourced biocompounds have been investigated for their neuroprotective potential. Thus, this review aims to describe the recent findings regarding the neuroprotective effects of the significant marine-sourced biocompounds.

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Anti-Inflammatory Effect of Lycopene on Experimental Spinal Cord Ischemia Injury via Cyclooxygenase-2 Suppression

Cited by 22 publications

References 34 publications

Hormetic Effects of Bioactive Compounds from Foods, Beverages, and Food Dressing: The Potential Role in Spinal Cord Injury

Hormetic Effects of Bioactive Compounds from Foods, Beverages, and Food Dressing: The Potential Role in Spinal Cord Injury

The Protective Effect of Lycopene on Ischemia/Reperfusion Injury in Rat Hind Limb Muscle Model

Marine Biocompounds for Neuroprotection—A Review

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