“…Studies have shown that PBMt is capable favoring the transformation of macrophages into M2 phenotype which alleviate inflammation and promotes tissue repair and remodeling. 1,26 Current literature regarding the use of PBMt for bone regeneration is mainly sourced from orthodontic applications reporting the suitability of the procedure for reducing pain and inflammation, 26,27 periodontitis management, 26,28 and bone remodeling during tooth movement. 29,30 However, independent studies are still being conducted regarding the use of PBMt for regenerating critical sized bone defects in animal models, [31][32][33] enhancing results of distraction osteogenesis, 34,35 regenerating irradiated bone, 36 repair bone lesions, 37 manage osteoporosis, 38,39 and resolve osteonecrosis.…”