Anti-inflammatory effect of Impatiens textori Miq. extract via inhibition of NLRP3 inflammasome activation in in vitro and in vivo experimental models

Sun, Xiao; Shim, Do-Wan; Han, Jiwon; Shin, Woo-Young; E, Sim; Kim, Myong-Ki; Heo, Kang-Hyuck; Kim, Young-Kyu; Koppula, Sushruta; Kim, Tack-Joong; Kang, Tae-Bong; Lee, Kwang-Ho

doi:10.1016/j.jep.2015.05.001

Cited by 22 publications

(10 citation statements)

References 26 publications

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“…Pro-inflammatory cytokines such as TNF-α, IL-1, and IL-6 from the hyperactive macrophages through activating internal pro-inflammatory signaling pathways, which in turn activated macrophages, resulting in a pro-inflammatory cascade reactions. Activated macrophages are a major source of inflammation related molecules 38 39 . Therefore, peritoneal macrophage from severely burned rats was chosen as study object to elucidate direct pro-inflammatory and anti-inflammatory mechanisms.…”

Section: Discussionmentioning

confidence: 99%

TSG-6 secreted by human umbilical cord-MSCs attenuates severe burn-induced excessive inflammation via inhibiting activations of P38 and JNK signaling

Liu

Song

Duan

et al. 2016

Sci Rep

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The hMSCs have become a promising approach for inflammation treatment in acute phase. Our previous study has demonstrated that human umbilical cord-MSCs could alleviate the inflammatory reaction of severely burned wound. In this study, we further investigated the potential role and mechanism of the MSCs on severe burn-induced excessive inflammation. Wistar rats were randomly divided into following groups: Sham, Burn, Burn+MSCs, Burn+MAPKs inhibitors, and Burn, Burn+MSCs, Burn+Vehicle, Burn+siTSG-6, Burn+rhTSG-6 in the both experiments. It was found that MSCs could only down-regulate P38 and JNK signaling, but had no effect on ERK in peritoneal macrophages of severe burn rats. Furthermore, suppression of P38 and JNK activations significantly reduced the excessive inflammation induced by severe burn. TSG-6 was secreted by MSCs using different inflammatory mediators. TSG-6 from MSCs and recombinant human (rh)TSG-6 all significantly reduced activations of P38 and JNK signaling induced by severe burn and then attenuated excessive inflammations. On the contrary, knockdown TSG-6 in the cells significantly increased phosphorylation of P38 and JNK signaling and reduced therapeutic effect of the MSCs on excessive inflammation. Taken together, this study suggested TSG-6 from MSCs attenuated severe burn-induced excessive inflammation via inhibiting activation of P38 and JNK signaling.

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Section: Discussionmentioning

confidence: 99%

TSG-6 secreted by human umbilical cord-MSCs attenuates severe burn-induced excessive inflammation via inhibiting activations of P38 and JNK signaling

Liu

Song

Duan

et al. 2016

Sci Rep

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“…Many studies have focused on using natural sources derived from plants containing anti‐inflammatory properties 10–13 . The Aloe family is composed of more than 300 species.…”

mentioning

confidence: 99%

“…Many studies have focused on using natural sources derived from plants containing anti-inflammatory properties. [10][11][12][13] The Aloe family is composed of more than 300 species. However, Aloe barbadensis, which grows mainly in dry areas of Africa, Asia, Europe, and America, exhibits the best medicinal properties.…”

mentioning

confidence: 99%

Aloin Inhibits Interleukin (IL)‐1β−Stimulated IL‐8 Production in KB Cells

Song

Kim

et al. 2016

Journal of Periodontology

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“…Maxim. significantly reduce IL‐1β production by inhibiting NLRP3 inflammasomes . Another study had shown that Korean red ginseng extracts suppress NLRP3 and AIM2 inflammasome activation, protecting mice from lethal endotoxin shock .…”

Section: Discussionmentioning

confidence: 99%

A hot‐water extract of Sanguisorba officinalis ameliorates endotoxin‐induced septic shock by inhibiting inflammasome activation

Seo

Cho

et al. 2018

Microbiology and Immunology

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The inflammasome is a multiprotein signaling complex that mediates inflammatory innate immune responses through caspase 1 activation and subsequent IL-1b secretion. However, because its aberrant activation often leads to inflammatory diseases, targeting the inflammasome holds promise for the treatment of inflammation-related diseases. In this study, it was found that a hot-water extract of Sanguisorba officinalis (HSO) suppresses inflammasome activation triggered by adenosine 5 0 -triphosphate, nigericin, microbial pathogens, and double stranded DNA in bone marrow-derived macrophages. HSO was found to significantly suppress IL-1b production in a dose-dependent manner; this effect correlated well with small amounts of caspase 1 and little ASC pyroptosome formation in HSO-treated cells. The anti-inflammatory activity of HSO was further confirmed in a mouse model of endotoxin-induced septic shock. Oral administration of HSO reduced IL-1b titers in the serum and peritoneal cavity, increasing the survival rate. Taken together, our results suggest that HSO is an inhibits inflammasome activation through nucleotide-binding domain and leucine-rich repeat pyrin domain 3, nucleotide-binding domain and leucine-rich repeat caspase recruitment domain 4 and absent in melanoma 2 pathways, and may be useful for treatment of inflammasomemediated diseases.Key words endotoxin-induced septic shock, hot-water extract, inflammasome, Sanguisorba officinalis.Sanguisorba officinalis is a member of the family Rosaceae. The root of this plant, called "Jiyu" in Korea, is often used in traditional oriental medicine to treat burns, scalds, diarrhea and internal hemorrhage (1). Various other beneficial effects of S. officinalis have recently been reported, including anti-allergic, antiwrinkle, anti-cancer, anti-oxidant, hemostatic and immunomodulatory activities (2-8). In a recent study, significantly greater amounts of anti-oxidant compounds-phenolics and flavonoids-were found in both water and ethanol extracts of S. officinalis than in other Chinese medicinal plants (9). An ethanolic extract of S. officinalis has been shown to exert anti-inflammatory and anti-asthmatic effects, these being mediated by nuclear factor-kappa B and activator protein 1 suppression and heme oxygenase-1 induction, respectively (10, 11). An aqueous extract of S. officinalis also reportedly shows anti-inflammatory activity with less toxicity (9), as

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Anti-inflammatory effect of Impatiens textori Miq. extract via inhibition of NLRP3 inflammasome activation in in vitro and in vivo experimental models

Cited by 22 publications

References 26 publications

TSG-6 secreted by human umbilical cord-MSCs attenuates severe burn-induced excessive inflammation via inhibiting activations of P38 and JNK signaling

TSG-6 secreted by human umbilical cord-MSCs attenuates severe burn-induced excessive inflammation via inhibiting activations of P38 and JNK signaling

Aloin Inhibits Interleukin (IL)‐1β−Stimulated IL‐8 Production in KB Cells

A hot‐water extract of Sanguisorba officinalis ameliorates endotoxin‐induced septic shock by inhibiting inflammasome activation

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