Aloin Inhibits Interleukin (IL)‐1β−Stimulated IL‐8 Production in KB Cells

Na, Hee Sam; Song, Yu Ri; Kim, Soyeon; Heo, Jun-Young; Chung, Hae Young; Chung, Jin

doi:10.1902/jop.2016.150447

Cited by 24 publications

(21 citation statements)

References 41 publications

(77 reference statements)

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“…Individuals having more missing teeth along with dental caries had elevated concentration of IL-1β. However, these findings contradict with another study,which reported that there was no significant difference of IL-1β in individuals with or without missing teeth or dental caries.Howsoever, this study shows that IL-1β value was significantly high in individuals with periodontitis and gingivitis and several studies support our results [38][39][40][41] . A cross-sectional study in adults (20-89 years) reported that IL-1β levels were significantly higher in participants with periodontitis (144pg/mL) compared to healthy participants (61pg/mL) 42 .…”

Section: Discussionsupporting

confidence: 85%

Evaluation of Salivary Interleukin-1ß Levels and Oral Health in Pakistani Male Smokers

Hamza¹,

Asif²,

Bokhari³

2021

PJMHS

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Aim: Smoking induces changes in salivary inflammatory biomarker levels associated with oral diseases. This study status and explored association among salivary Interleukin-1β, oral diseases and smoking. Methods: Data of male smokers of a private institute recruited for a randomized clinical trial is analyzed for this paper. Demographic and systemic information were collected. Oral disease status was examined and saliva sample collected for IL-1β levels. IL-1β levels and other study variables were analyzed with respect to smoking status categorized into smoking years and cigarettes per day. The student's t-test and one-way ANOVA were used for statistical analysis using SPSS version 22) with significance level of p≤0.050. Results: Analysis of baseline data of seventy-eight smokers showed elevated levels of IL-1β with increasing smoking, higher BMI. Smoking was higher among aged, married and low-income individuals. Pearson partial correlation analysis, after controlling age, marital status, education, income, and BMI, demonstrated a positive significant relationship of smoking per day with smoking years; dental caries with missing teeth and calculus; gingivitis with missing teeth and calculus; periodontitis with dental caries, calculus and gingivitis. Conclusion: This analysis demonstrates that levels of IL-1β were raised in smokers, however; there was no association with oral disease parameters. Large studies may be conducted to observe status and association of smoking, oral disease and salivary biomarkers. Keywords: Smoking, Oral Health, IL-1β, Males

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Section: Discussionsupporting

confidence: 85%

Evaluation of Salivary Interleukin-1ß Levels and Oral Health in Pakistani Male Smokers

Hamza¹,

Asif²,

Bokhari³

2021

PJMHS

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“…IL‐1β plays an important role in the inflammatory host response in periodontal diseases, and has been suggested to be effectual target for the control of periodontitis . IL‐1β processing and secretion are tightly regulated by a two‐step mechanism .…”

Section: Discussionmentioning

confidence: 99%

Trans‐cinnamic aldehyde inhibits Aggregatibacter actinomycetemcomitans‐induced inflammation in THP‐1–derived macrophages via autophagy activation

Chung

Kim

Lee

et al. 2018

Journal of Periodontology

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“…Another study has shown that compounds of aloe species inhibit the production of pro-inflammatory cytokines and nitric oxide via inhibition of the MAPK signalling pathway [15]. More studies proved that treatment of aloin decreased the high production of interleukin (IL)-8 induced by IL-1β in KB cells, through the inhibition of activity of p38 and extracellular signal-regulated kinases pathway [19,29]. In recent years, more and more researchers have found that oxidative stress promotes the secondary injury after TBI, and among multiple factors, nicotinamide adenine dinucleotide phosphate oxidase (NOX) is critical in regulating the production of ROS [1].…”

Section: Introductionmentioning

confidence: 99%

Inhibition of NOX2 contributes to the therapeutic effect of aloin on traumatic brain injury

Dong¹,

Wang²,

Zhang³

2020

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Traumatic brain injury (TBI) is a subset of brain injury induced by external mechanical forces to the head or neck. TBI has been reported to be one of the leading causes of disability, and it causes a huge financial burden around the world. Aloin is the major anthraquinone glycoside extracted from Aloe species, and has presented anti-tumour, antioxidative and anti-inflammatory activities. However, few studies have focused the effect of aloin in treatment of TBI. Nicotinamide adenine dinucleotide phosphate oxidase (NOX) is the only subset of enzymes which produces solely the reactive oxygen species (ROS). A recent study showed that activation of NOX might aggravate the primary TBI, and among these members, NOX2 is the key member in regulation of uncontrolled ROS expression, and thus plays a critical role in development of inflammatory diseases. Here, we noticed that inhibition of NOX2 combined with aloin treatment promoted the recovery of brain function in a mice model as well as the viability rate in a cell model. A further study found that the inflammation response process was also inhibited after treatment. Then, we found that these effects might be mediated by the PI3K/AKT/mTOR signalling pathway and NOX2 might be a therapeutic target for TBI.

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Aloin Inhibits Interleukin (IL)‐1β−Stimulated IL‐8 Production in KB Cells

Abstract: Results indicated that IL-1β in saliva stimulates epithelial cells to produce IL-8 and that aloin effectively inhibits salivary IL-1β-induced IL-8 production by mitigating the p38 and ERK pathway. Therefore, aloin may be a good candidate for modulating oral inflammatory diseases.

Cited by 24 publications

References 41 publications

Evaluation of Salivary Interleukin-1ß Levels and Oral Health in Pakistani Male Smokers

Evaluation of Salivary Interleukin-1ß Levels and Oral Health in Pakistani Male Smokers

Trans‐cinnamic aldehyde inhibits Aggregatibacter actinomycetemcomitans‐induced inflammation in THP‐1–derived macrophages via autophagy activation

Inhibition of NOX2 contributes to the therapeutic effect of aloin on traumatic brain injury

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