Anti-inflammatory Effect of Hydroalcoholic Extract of the Washingtonia filifera Seeds in Carrageenan-Induced Paw Edema in Rats

Hemmati, Ali Asghar; Kalantari‬, Heibatullah; Siahpoosh, Amir; Ghorbanzadeh, Behnam; Jamali, Hassan

doi:10.17795/jjnpp-19887

Cited by 7 publications

(3 citation statements)

References 35 publications

(31 reference statements)

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“…The carrageenan-induced paw edema in rat is an acute inflammation model widely used for the screening of synthetic or natural anti-inflammatory products [26]. The acute inflammatory response is a protective mechanism of the body to remove the injurious stimuli that involve local cellular and vascular processes following tissue damage [1].…”

Section: Discussionmentioning

confidence: 99%

The Effect of Prickly Pear, Pumpkin, and Linseed Oils on Biological Mediators of Acute Inflammation and Oxidative Stress Markers

Bardaa

Turki

Khedir

et al. 2020

BioMed Research International

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Medicinal plants have been used as a source of effective and safe alternative therapeutic agents for various ailments including inflammation. In fact, the aim of this study is to assess the topical anti-inflammatory and antioxidative potential effects of Cucurbita pepo (pumpkin), Linum usitatissimum (linseed), and Opuntia ficus indica (prickly pear) oils on acute inflammation using carrageenan-induced paw edema model. The study was conducted on 36 rats splitted in 6 groups: a normal control group and 5 carrageenan-treated groups (1%), each treated with either a normal saline, the reference drug (“Inflocine®” 2 mg/paw), pumpkin, linseed, or prickly pear oils (25 μl/paw). The response to these treatments was mainly assessed by the measuring of edema paw size, hematological and biochemical analysis, oxidative stress testing, and histological study. All the studied seed oils especially prickly pear oil proved to be efficient in treating acute inflammation. The oil-treated groups revealed a significant (p<0.05) decrease in the clinical signs of inflammation, hematological parameters (white blood cells and platelets), concentrations of CRP and fibrinogen, and congestion compared to the normal saline-treated group. The results also showed that the tested oils, endowed with a radical scavenging ability, could significantly increase the activities of SOD, CAT, and GPx in carrageenan-treated skin by reducing the lipid peroxidation and protein oxidation (TBARS, AOPP). The anti-inflammatory effect of the tested oils was closely related to both their antioxidant properties as well as their bioactive compounds (polyunsaturated fatty acids, vitamin E, and phytosterols). For the first time, the findings of the current study highlight the “in vivo” anti-inflammatory property of pumpkin, linseed, and prickly pear oils on carrageenan-induced acute inflammation by regulating inflammatory mediators and oxidative stress markers.

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Section: Discussionmentioning

confidence: 99%

The Effect of Prickly Pear, Pumpkin, and Linseed Oils on Biological Mediators of Acute Inflammation and Oxidative Stress Markers

Bardaa

Turki

Khedir

et al. 2020

BioMed Research International

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“…The experimental study of anti-inflammatory activity is performed by the Carr test. This phlogiston agent induced tissue oedema characteristic of acute inflammation which is regarded as a crucial parameter in assessing anti-inflammatory activity [ 44 ].…”

Section: Discussionmentioning

confidence: 99%

Chemicals Compositions, Antioxidant and Anti-Inflammatory Activity ofCynara scolymusLeaves Extracts, and Analysis of Major Bioactive Polyphenols by HPLC

Salem

Affes

Athmouni

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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Objective. Artichoke (Cynara scolymus L.) was one of the plant remedies for primary health care. The present study was focused on the determination of chemical composition, antioxidant activities, and anti-inflammatory activity and on analyzing its major bioactive polyphenols by HPLC. Methods. Artichoke Leaves Extracts (ALE) were analyzed for proximate analysis and phytochemical and antioxidant activity by several methods such as DDPH, ABTS, FRAP, and beta-carotene bleaching test. The carrageenan (Carr) model induced paw oedema in order to investigate the anti-inflammatory activity. Identification and quantification of bioactive polyphenols compounds were done by HPLC method. The oxidative stress parameters were determined; CAT, SOD, GSH, MDA, and AOPP activities and the histopathological examination were also performed. Results. It was noted that EtOH extract of ALE contained the highest phenolic, flavonoid, and tannin contents and the strongest antioxidants activities including DDPH (94.23%), ABTS (538.75 mmol), FRAP assay (542.62 umol), and β-carotene bleaching (70.74%) compared to the other extracts of ALE. Administration of EtOH extract at dose 400 mg/kg/bw exhibited a maximum inhibition of inflammation induced by Carr for 3 and 5 hours compared to reference group Indomethacin (Indo). Conclusion. ALE displayed high potential as natural source of minerals and phytochemicals compounds with antioxidant and anti-inflammatory properties.

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“…Unsaturated fatty acid can influence biochemical properties of a membrane, such as fluidity and permeability [17]. The hydroalcoholic extract of W. filifera seeds were reported to exhibit anti-inflammatory effects comparable to indomethacin (10 mg/kg) [18]. Additionally, the seed oil of W. filifera has high oleic acid content (40.6%) [13], which could be used in the cosmetics.…”

Section: Nutritional Value As a Food Resourcementioning

confidence: 99%

Bioactive Compounds of California Fan Palm Washingtonia filifera (Linden ex André) H. Wendl. ex de Bary

Dewir¹,

El-Mahrouk²,

Seliem³

et al. 2019

Reference Series in Phytochemistry

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The fruit of the California fan palm (Washingtonia filifera) is underutilized. Phytochemical analysis of the fruit has demonstrated its high nutritional values. The fruit is a good source of carbohydrates, soluble sugars, and minerals including calcium, phosphorus, potassium, magnesium, and zinc. The fruit has several bioactive compounds having antioxidant, antibacterial, antifungal, and antiinflammatory properties. Moreover, unlike other palm species, W. filifera tree is resistant to red palm weevil, which encourages its cultivation as a potential widely used food source.

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Anti-inflammatory Effect of Hydroalcoholic Extract of the Washingtonia filifera Seeds in Carrageenan-Induced Paw Edema in Rats

Cited by 7 publications

References 35 publications

The Effect of Prickly Pear, Pumpkin, and Linseed Oils on Biological Mediators of Acute Inflammation and Oxidative Stress Markers

The Effect of Prickly Pear, Pumpkin, and Linseed Oils on Biological Mediators of Acute Inflammation and Oxidative Stress Markers

Chemicals Compositions, Antioxidant and Anti-Inflammatory Activity ofCynara scolymusLeaves Extracts, and Analysis of Major Bioactive Polyphenols by HPLC

Bioactive Compounds of California Fan Palm Washingtonia filifera (Linden ex André) H. Wendl. ex de Bary

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