Anti-inflammatory effect of Calycosin glycoside on lipopolysaccharide-induced inflammatory responses in RAW 264.7 cells

Dong, Lin; Yin, Lei; Chen, Rong; Zhang, Yuanbin; Hua, Shiyao; Quan, Hongfeng; Fu, Xueyan

doi:10.1016/j.gene.2018.06.057

Cited by 36 publications

(23 citation statements)

References 36 publications

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“…The purity of the calycosin is over 98%. in vitro experiments were divided into following groups with respective protocol: (a) control; (b) 1 μg/ml LPS (Dong et al, 2018); and…”

Section: Cell Culturementioning

confidence: 99%

Calycosin modulates inflammation via suppressing TLR4/NF‐κB pathway and promotes bone formation to ameliorate glucocorticoid‐induced osteonecrosis of the femoral head in rat

Zhu

Liu

et al. 2021

Phytotherapy Research

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“…The purity of the calycosin is over 98%. in vitro experiments were divided into following groups with respective protocol: (a) control; (b) 1 μg/ml LPS (Dong et al, 2018); and…”

Section: Cell Culturementioning

confidence: 99%

Calycosin modulates inflammation via suppressing TLR4/NF‐κB pathway and promotes bone formation to ameliorate glucocorticoid‐induced osteonecrosis of the femoral head in rat

Zhu

Liu

et al. 2021

Phytotherapy Research

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“…Clinically, drugs such as 5‐aminosalicylic acid and infliximab are used to manage UC due to their anti‐inflammatory capacities. It has been proven that these four components all have anti‐inflammatory activity (Cabalin, Villalobos‐Labra, Toledo, & Sobrevia, 2019; Dong et al., 2018; Dong, Yin, Zhang, Fu, & Lu, 2017; Lima Cavendish et al., 2015). Comparable with clinical drugs, the therapeutic effect of EE on UC is probably caused by the anti‐inflammatory activity of its active ingredients.…”

Section: Resultsmentioning

confidence: 99%

The amelioration of ulcerative colitis induced by Dinitrobenzenesulfonic acid with Radix Hedysari

et al. 2020

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Ulcerative colitis (UC) is a chronic, relapsing inflammatory disease of the gastrointestinal tract that can develop into colon cancer (O'Keefe, 2016). UC lesions mainly involve the mucosal and submucosa layers (Sireswar, Ghosh, & Dey, 2019). Its precise etiology is unknown; the cause of UC is postulated to be multifactorial in nature, with factors including genetic predisposition, dysregulation of immune responses, epithelial barrier defects, and environmental

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“…The anti-inflammatory properties of calycosin were widely documented on lipopolysaccharide- (LPS-) induced RAW 264.7 cells [ 41 , 44 ]. Calycosin significantly attenuated nitric oxide (NO), prostaglandin E2 (PGE2), TNF- α , IL-1 β , and IL-6 releases, and the anti-inflammatory properties had been confirmed by NF- κ B and MAPK signal pathways [ 44 ]. The effective dosage was from 30 nM to 5 μ M, and the inhibitory function was dose-dependent.…”

Section: Pharmacological Activities Of Calycosinmentioning

confidence: 99%

Pharmaceutical Values of Calycosin: One Type of Flavonoid Isolated from Astragalus

Gong

Zheng

Yang

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Astragalus is a popular Materia Medica in China, and it could be applied in the treatment of various diseases. It contains a variety of chemically active ingredients, such as saponins, flavonoids, and polysaccharides. Plant-derived bioactive chemicals are considered natural, safe, and beneficial. Among the infinite plant-identified and isolated molecules, flavonoids have been reported to have positive effects on human health. Calycosin is the most important active flavonoid substance identified predominantly within this medicinal plant. In recent years, calycosin has been reported to have anticancer, antioxidative, immune-modulatory, and estrogenic-like properties. This review collected recent relevant literatures on calycosin and summarized its potential pharmaceutical properties and working mechanism involved, which provided solid basis for future clinical research.

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Anti-inflammatory effect of Calycosin glycoside on lipopolysaccharide-induced inflammatory responses in RAW 264.7 cells

Cited by 36 publications

References 36 publications

Calycosin modulates inflammation via suppressing TLR4/NF‐κB pathway and promotes bone formation to ameliorate glucocorticoid‐induced osteonecrosis of the femoral head in rat

Calycosin modulates inflammation via suppressing TLR4/NF‐κB pathway and promotes bone formation to ameliorate glucocorticoid‐induced osteonecrosis of the femoral head in rat

The amelioration of ulcerative colitis induced by Dinitrobenzenesulfonic acid with Radix Hedysari

Pharmaceutical Values of Calycosin: One Type of Flavonoid Isolated from Astragalus

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