Anti-inflammatory effect of caffeic acid methyl ester and its mode of action through the inhibition of prostaglandin E2, nitric oxide and tumor necrosis factor-α production

Shin, Kyung-Min; Kim, In-Tae; Park, Young-Mi; Ha, Joohun; Choi, Jongwon; Park, Hee-Juhn; Lee, Yong Sup; Lee, Kyung‐Tae

doi:10.1016/j.bcp.2004.08.002

Cited by 94 publications

(65 citation statements)

References 31 publications

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“…The E. foetidum leaf extract contains kaempferol, chlorogenic acid, caffeic acid, lutein, and β-carotene. All components have been previously reported to have anti-inflammatory activities, and some also have antioxidant activities (Ching et al, 2002;Lee et al, 2004;Shin et al, 2004;Bai et al, 2005;Kowalski et al, 2005;dos Santos et al, 2006;Hamalainen et al, 2007;Chao et al, 2009;Shan et al, 2009;Zhang et al, 2010). Several bioactive compounds in E. foetidum leaves were recently reported (Paul et al, 2010) to play a role in anti-inflammatory and antioxidant activities.…”

Section: Discussionmentioning

confidence: 97%

Eryngium foetidum Suppresses Inflammatory Mediators Produced by Macrophages

Mekhora

Muangnoi²,

Chingsuwanrote

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Section: Discussionmentioning

confidence: 97%

Eryngium foetidum Suppresses Inflammatory Mediators Produced by Macrophages

Mekhora

Muangnoi²,

Chingsuwanrote

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…These discoveries can be mainly attributed to the phenolic compounds and derivatives. The phenolic compounds and derivatives (flavonoids and tannins) can simultaneously inhibit the oxidation of the arachidonic acid stopping the synthesis of prostaglandin E2 and thus reducing the swelling (Shin et al, 2004). It also suggests that the triterpenes and saponins, found in the methanolic extract, also have a part in this capacity.…”

Section: Discussionmentioning

confidence: 99%

Wound-Healing potential of Sebastiania hispida (Mart.) Pax (Euphorbiaceae) ointment compared to low power laser in rats

et al. 2016

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Impaired wound healing represents a serious complication in some pathologies and the use of plant extracts has proved to improve tissue repair. The objectives of this study were to evaluate the healing potential of the ointment of Sebastiana hispida compared with Aluminum-Gallium Indium-Phosphide Laser (InGaAlP) in surgically induced wounds in rats and to perform the phytochemical analysis. The phytochemical analysis was performed in the classic way and also by HPLC. A controlled study was developed with 80 rats (200-250 g) in which a linear excision was performed in the dorsal region after shaving, measuring 2 cm × 1 cm (epidermis and dermis) exposing the muscle fascia. The rats were randomly divided into four groups of twenty animals each. The experimental groups (n = 5) were G1 (Saline); G2 (crude methanol plant extract 2% + Carbopol Gel 98%); G3 (crude methanol plant extract 2% + lanolin/vaseline) and G4 (laser). The incision healing processes were monitored during 3, 7, 14 and until 21 days after excision. The histologic parameters evaluated were Collagen fiber types, microscopic examination and neovascularization. There was a significant increase in the deposition of collagen fibers, as evidenced by a better organized epithelial tissue, keratinized and showing greater proliferation of new blood vessels in the inflammatory phase in the group treated with both the extract and laser. The results were correlated to the phenolic derivatives found after qualitative and quantitative analysis. These compounds were considered responsible for the healing process. The topical treatment with S. hispida leaves, in the two different formulations, was more effective than the application of the laser (Ingan ALP) 660 nm in the model used.Keywords: laser therapy, tissue repair, inflammatory cells, medicinal plants. Potencial cicatrizante da pomada de Sebastiania hispida (Mart.) Pax (Euphorbiaceae) comparado ao laser de baixa potência ResumoA cicatrização deficiente representa uma complicação grave em algumas patologias e o uso de extratos de plantas tem demonstrado melhora no processo de reparação tecidual. O objetivo deste estudo foi avaliar o potencial cicatrizante da pomada de Sebastiania hispida comparado ao Laser Indio Phosphide-Gallium-Aluminum (InGaAlP) em feridas cutâneas induzidas cirurgicamente em ratos e realizar analise fitoquímica. A análise fitoquímica foi via clássica e por CLAE. O experimento foi desenvolvido com 80 ratos (200-250 g), divididos aleatoriamente em quatro grupos (n = 5): G1 (salina); G2 (extrato bruto metanólico 2% + Carbopol Gel 98%); G3 (extrato bruto metanólico 2% + lanolina/ vaselina) e G4 (laser). Após a tricotomia da região dorsal realizou uma excisão linear, medindo 2 cm × 1 cm (epiderme e derme), expondo a fáscia muscular. Em sequência os tratamentos e o monitoramento do processo de cicatrização das feridas cirúrgicas ocorreu nos tempos de: 3, 7, 14 e até 21 dias após a excisão. Os parâmetros histológicos avaliadosBraz.

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“…Compound D 16 has a -Br at the p-position of the benzene ring, and the addition of one -F at the o-position led to D 14 along with a decrease in the biological activity. From the above fact, one rule could be found: amide groups with one substituent at the p-position of the benzene ring tend to display potent cell anti-proliferation activity.…”

Section: Anti-proliferative Activitymentioning

confidence: 99%

“…Caffeic acid and its derivatives possess a wide range of biological activities such as antimicrobial [13], anti-inflammatory [14], antioxidant [15], antimutagenic [16] and anti-HIV [17]. Besides, it also displays potential antitumor activities.…”

Section: Introductionmentioning

confidence: 99%