Anti-inflammatory effect of an adhesive resin containing indomethacin-loaded nanocapsules

Genari, Bruna; Ferreira, Maria Beatriz Cardoso; Medeiros, Liciane Fernandes; Freitas, Joel; Cioato, Stefânia Giotti; Torres, Iraci Lucena da Silva; Pohlmann, Adriana Raffin; Guterres, Sílvia Stanisçuaski; Leitune, Vicente Castelo Branco; Collares, Fabrício Mezzomo; Samuel, Susana Maria Werner

doi:10.1016/j.archoralbio.2017.09.016

Cited by 9 publications

(5 citation statements)

References 34 publications

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“…Application Oral Diseases Composition micro/nano particles micro/nano sphere dental caries [31,35] periodontitis [38] implant coating [50,51] oral candidiasis [52] PLGA, PDLLA, PEG and biopolymers like lipid, chitosan, pectin, and alginate nanofiber periodontitis [19] oral candidiasis [53] implant coating [43] nano capsule dental resin modification [42] hydrogel dental caries [54] periodontitis [55,56] oral candidiasis [57] Hydrophilic groups such as -OH, -CONH-, -CONH2dendrimer dental caries [58] PAMAM, poly(aryl ether) Figure 1. Examples of the structures of different kinds of carriers.…”

Section: Types Of Carriersmentioning

confidence: 99%

“…For example, some nanoparticles and nano capsules have been added to dental resin for caries prevention loaded with anti-bacterial agents while nanofibers can be coating on dental implants as since they could act as a scaffold for tissue regeneration. Recently, research has also reported pH-responsive nanoparticles that could respond to the acidic oral environment [42,43]. The nanoparticles modified with pH-sensitive groups such as tertiary amine showed structural changes in acid, thus leading to trigged drug release [47].…”

Section: Micro/nanoparticlesmentioning

confidence: 99%

“…What's more, to reduce the inflammatory response of pulp caused by deep dental caries, anti-inflammatory agents such as indomethacin have also been combined in the dental resin [104]. Genari et al reported indomethacin-loaded nano-capsules which could reduce the nociceptive and inflammatory response in vivo [42]. They also combined anti-bacterial agents yielding dual-functional DDS modified dental resin with controlled indomethacin and triclosan release, significant antimicrobial effect without compromising its physicochemical properties [105,106].…”

Section: Dds For Secondary Cariesmentioning

confidence: 99%

“…The carriers could be designed and modified for the loading of anti-bacterial agents [35][36][37], anti-inflammatory drugs [38], and biomolecules like protein and gene, growth factors, which expanded the application of DDS in oral diseases [39][40][41]. These nano-scaled DDS are combined with dental materials like dental restoration systems and dental implants for anti-bacterial modification without affecting their basic properties [42,43]. Further, hydrogel DDS with great biocompatibility and high drug-loading rate have also been applied in oral diseases, especially in periodontal diseases.…”

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confidence: 99%

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Emerging Applications of Drug Delivery Systems in Oral Infectious Diseases Prevention and Treatment

et al. 2020

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The oral cavity is a unique complex ecosystem colonized with huge numbers of microorganism species. Oral cavities are closely associated with oral health and sequentially with systemic health. Many factors might cause the shift of composition of oral microbiota, thus leading to the dysbiosis of oral micro-environment and oral infectious diseases. Local therapies and dental hygiene procedures are the main kinds of treatment. Currently, oral drug delivery systems (DDS) have drawn great attention, and are considered as important adjuvant therapy for oral infectious diseases. DDS are devices that could transport and release the therapeutic drugs or bioactive agents to a certain site and a certain rate in vivo. They could significantly increase the therapeutic effect and reduce the side effect compared with traditional medicine. In the review, emerging recent applications of DDS in the treatment for oral infectious diseases have been summarized, including dental caries, periodontitis, peri-implantitis and oral candidiasis. Furthermore, oral stimuli-responsive DDS, also known as "smart" DDS, have been reported recently, which could react to oral environment and provide more accurate drug delivery or release. In this article, oral smart DDS have also been reviewed. The limits have been discussed, and the research potential demonstrates good prospects.Molecules 2020, 25, 516 2 of 29 problems. For example, systemic antibiotics such as tetracycline, beta-lactam antibiotics, nitroimidazoles have been used, especially in cases of periodontal diseases and peri-implantitis [12]. However, systemic antibiotics could cause problems like drug resistance, dysbacteriosis, and systemic side effects [13,14]. The antibacterial effect is also limited as very little could arrive at the oral lesion area after systemic circulation [15][16][17]. Fluoride in drinking water has been used for the prevention of dental caries but might cause excessive intake, leading to fluorosis [18]. Therefore, local drug therapy is now more considered for oral infectious diseases [19,20]. However, the conventional forms of local therapy, like drug suspension or rinse of anti-infection agents, could be easily washed off and thus could not last long in the oral cavity. Complex local lesions like deep periodontal pockets and teeth fissure are also difficult to reach. In order to improve the effect of prophylaxis and treatment, more precise targeting therapy is quite essential [21,22]. Therefore, drug delivery systems have drawn great attention in recent decades in oral infectious diseases. Drug delivery systems (DDS) are devices that can transport and release the therapeutic agents or bioactive substances to certain sites at certain rates in vivo [23,24], usually composed of the carriers and associated therapeutics [25]. They have been widely explored in biomedical research. With local drug administration and controlled drug release, DDS could provide higher curative efficiency and fewer side effects [23,26,27]. With all these advantages, DDS has been reported w...

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Section: Types Of Carriersmentioning

confidence: 99%

Section: Micro/nanoparticlesmentioning

confidence: 99%

Section: Dds For Secondary Cariesmentioning

confidence: 99%

mentioning

confidence: 99%

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Emerging Applications of Drug Delivery Systems in Oral Infectious Diseases Prevention and Treatment

et al. 2020

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“…This test is most commonly used to determine mechanical hyperalgesia and tactile allodynia related to neuropathic pain in both rats and mice [ 4 , 41 , 42 , 108 ]. It is a gold standard used to determine the mechanical threshold in rodent [ 4 ].…”

Section: Non-inflammatory Behavioral Pain Study In Animal Modelsmentioning

confidence: 99%

Overview of Neurological Mechanism of Pain Profile Used for Animal “Pain-Like” Behavioral Study with Proposed Analgesic Pathways

Yam

Loh

et al. 2020

IJMS

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Pain is the most common sensation installed in us naturally which plays a vital role in defending us against severe harm. This neurological mechanism pathway has been one of the most complex and comprehensive topics but there has never been an elaborate justification of the types of analgesics that used to reduce the pain sensation through which specific pathways. Of course, there have been some answers to curbing of pain which is a lifesaver in numerous situations—chronic and acute pain conditions alike. This has been explored by scientists using pain-like behavioral study methodologies in non-anesthetized animals since decades ago to characterize the analgesic profile such as centrally or peripherally acting drugs and allowing for the development of analgesics. However, widely the methodology is being practiced such as the tail flick/Hargreaves test and Von Frey/Randall–Selitto tests which are stimulus-evoked nociception studies, and there has rarely been a complete review of all these methodologies, their benefits and its downside coupled with the mechanism of the action that is involved. Thus, this review solely focused on the complete protocol that is being adapted in each behavioral study methods induced by different phlogogenic agents, the different assessment methods used for phasic, tonic and inflammatory pain studies and the proposed mechanism of action underlying each behavioral study methodology for analgesic drug profiling. It is our belief that this review could significantly provide a concise idea and improve our scientists’ understanding towards pain management in future research.

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Drug Delivery Systems and Oral Biofilm

Ceniceros¹,

González²,

Tijerina³

et al. 2023

Advances in Novel Formulations for Drug Delivery

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Anti-inflammatory effect of an adhesive resin containing indomethacin-loaded nanocapsules

Cited by 9 publications

References 34 publications

Emerging Applications of Drug Delivery Systems in Oral Infectious Diseases Prevention and Treatment

Emerging Applications of Drug Delivery Systems in Oral Infectious Diseases Prevention and Treatment

Overview of Neurological Mechanism of Pain Profile Used for Animal “Pain-Like” Behavioral Study with Proposed Analgesic Pathways

Drug Delivery Systems and Oral Biofilm

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