Anti-inflammatory effect of Acacia visco extracts in animal models

Pedernera, Ana; Guardia, Teresita; Calderón, Carola Elisa Guardia; Rotelli, Alejandra Ester; Rocha, Nadir Ernesto de la; Saad, José Roberto Cury; Verrilli, María A. Lopez; Aseff, S. García; Pelzer, Lilian Eugenia

doi:10.1007/s10787-009-0028-6

Cited by 17 publications

(5 citation statements)

References 29 publications

(23 reference statements)

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“…Two hours after CG injection, there is the release of histamine, 5-hydroxytryptamine, bradykinin, and serotonin, among other substances. Afterwards, increased COX-2 expression and prostaglandin production, monocyte mobilization, macrophage migration, and nitric oxide production maintain the edema up to 4 to 6 h after CG injection [23,24].…”

Section: Sammentioning

confidence: 99%

An Ethanolic Extract of Boehmeria caudata Aerial Parts Displays Anti-inflammatory and Anti-tumor Activities

Paiva

Nonato

Ruiz

et al. 2020

PMIO

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The tumor microenvironment presents several therapeutic targets, with inflammation being one of them. In search of new drugs, plants have shown to be an effective source of potent anti-inflammatory and anticancer agents. This study aimed to evaluate the antitumoral and inflammatory activities of Boehmeria caudata aerial parts extract. Bioguided in vitro antiproliferative screening showed that phenanthroquinolizidine obtained from the aerial B. caudata ethanolic extract had a straight relationship with activity. Moreover, the orally administered ethanolic extract reduced Ehrlich solid tumor growth and displayed an anti-inflammatory effect in both evaluated experimental models (carrageenan-induced paw edema and croton oil-induced ear edema). These results suggest that the antitumor activity of the ethanolic extract could be explained by antiproliferative effects associated with anti-inflammatory action.

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Section: Sammentioning

confidence: 99%

An Ethanolic Extract of Boehmeria caudata Aerial Parts Displays Anti-inflammatory and Anti-tumor Activities

Paiva

Nonato

Ruiz

et al. 2020

PMIO

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“…Lupeol is the highest compound in n-hexane extract (16,52%). Lupeol also found in the stem bark of Acacia mellifera and Acacia visco, and its antimicrobial and anti-inflammatory activities have been already demonstrated (Mutai et al 2009, Pedemera et al 2010. Lupeol is the pentacyclic triterpenes belonging to the lupane family.…”

Section: Chemical Component Of Five Natural Extractsmentioning

confidence: 99%

Chemical variation of five natural extracts by non-polar solvent

Prayitno

Widyorini

Lukmandaru

2020

Maderas, Cienc. tecnol.

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Chemical compounds of wood preservation from plants vary and are not known specific to the species. Chemical analysis of plants is responsible to ensure active compound in natural extracts wood treatment. There are many sources of natural extracts found in Indonesia that were explored for wood preservatives chemicals. They are bark of acacia and alstonia, leaves of orthosiphon and azardirachta and Dioscorea tubers. The present study was aimed at investigating the variation of the chemical constituent of natural extracts material of wood preservative through GC-MS analysis. Five natural extract sources were acacia bark (Acacia spp.), pulai bark (Alstonia scholaris), kumis kucing leaves (Orthosiphon spp.), mimba leaves (Azardirachta indica), and gadung tubers (Dioscorea spp.). Two non-polar solvents, i.e., n-hexane and petroleum ether were used for five natural source extractions following ASTM soxhlet extraction. The research showed that triterpene and fatty acid derivatives were the major compounds present in five natural extracts.

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“…In this study, the phytochemical composition of crude Faidherbia albida (Mimosaceae) roots and leaves extracts and fractions from methylene chloride/methanol (1v, 1v), n-hexane, and ethyl acetate solvents, afforded 14 compounds for the first time by silica gel column chromatography and identified as 3β-Friedelinol 26 (1), Friedelan-3-one 27 (2), Heptadecanoic acid 28 4a,6b,8a,11,11,12b,14a-octamethyl-docosahydropicen-3-yloxy)-tetrahydro-2H-pyran-3,4,5-triol 30 (5), Brassicasterol Benzoate 31 (6), Kaempferol 32 (7), Trans-Tiliroside 33 (8), Lupeol [33][34] (9), Betulin 27 (10), Maslinic acid 27 (11), Oleanolic acid 35 (12), Quercetin-3-O-αrhamnoside 30 (13) and Apigenin 30 (14). The structures of the compounds were determined by analysis of their NMR data and comparison with those reported in the literature (Figure 1).…”

Section: Fractionation and Isolation Of Compounds Using Column Chromamentioning

confidence: 99%

Phytochemical Composition and Biological Activity of Faidherbia albida (Mimosaceae) Roots and Leaves

Bruno¹,

Desire²,

Tchouboun³

et al. 2020

IJPSRR

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Phytochemical composition of roots and leaves of Faidherbia albida, let to the isolation and the identification of fourteen (14) compounds namely 3β-Friedelinol (1), Friedelan-3-one (2), Heptadecanoic acid (3), Ergosterol-β-D-glucoside (4), (3R,4R,5S,6R)-2-(hydroxymethyl)-6-(4,4a,6b,8a,11,11,12b,14a-octamethyl-docosahydropicen-3-yloxy)-tetrahydro-2H-pyran-3,4,5-triol (5), Brassicasterol Benzoate (6), Lupeol (7), Betulin (8), Oleanolic acid (9), Maslinic acid (10), Apigenin (11) Kaempferol (12)], Quercetin-3-O-α-rhamnoside (13) and Trans-Tiliroside (14). The structures of all the isolated constituents were determined by a comprehensive use of spectroscopic analysis such as 1D-and 2D-NMR, EI-MS, and ESI-MS coupled with the comparison of data thereof obtained with those of known analogs listed in the literature. These compounds and various extracts, fractions were investigated for their antioxidant potential, and antischistosomal and antifungal effects against Schistosoma mansoni and Candida albicans respectively, α-Glucosidal and Trypsin activity. The results revealed that all the extracts (roots and leaves), exhibited antifungal, antioxidant and enzyme α-Glucosidase inhibition activities. Moreover, Quercetin-3-O-α-rhamnoside (13) inhibited α-Glucosidase, Trypsin and Schistosoma mansoni. The synergic effect of the extract and fraction, and also their triple of Quercetin-3-O-α-rhamnoside (13) could classified Faidherbia albida among the potential candidate for the development of multitarget drugs. This could reduce the combination of multiple biological active agent (multitherapy) therapy in favor of multitarget drug strategies.

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Anti-inflammatory effect of Acacia visco extracts in animal models

Cited by 17 publications

References 29 publications

An Ethanolic Extract of Boehmeria caudata Aerial Parts Displays Anti-inflammatory and Anti-tumor Activities

An Ethanolic Extract of Boehmeria caudata Aerial Parts Displays Anti-inflammatory and Anti-tumor Activities

Chemical variation of five natural extracts by non-polar solvent

Phytochemical Composition and Biological Activity of Faidherbia albida (Mimosaceae) Roots and Leaves

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