Anti-inflammatory Effect from a Hydrogel Containing Nanoemulsified Copaiba oil (Copaifera multijuga Hayne)

Lucca, Letícia Grolli; Matos, Sheila Porto de; Kreutz, Tainá; Teixeira, Hélder Ferreira; Veiga, Valdir Florêncio da; Araújo, Bibiana Verlindo de; Limberger, Renata Pereira; Koester, Letícia Scherer

doi:10.1208/s12249-017-0862-6

Cited by 37 publications

(25 citation statements)

References 28 publications

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“…The positive regulatory effects of copaiba essential oil peaked at 30 min with an EC 50 of approximately 80 ng/mL and were mediated in part by CB2. The positive effects of copaiba essential oil on neuronal signaling pathways were consistent with its reported functions in metabolism [32], wound healing [33][34][35][36], and anti-inflammation [37][38][39][40][41]. Interestingly, copaiba essential oil also activated the apoptosis signaling pathway in a time-dependent manner and reduced the viability of neuronal cells with an EC 50 of approximately 400 ng/mL.…”

Section: Discussionsupporting

confidence: 79%

Fast-Acting and Receptor-Mediated Regulation of Neuronal Signaling Pathways by Copaiba Essential Oil

Urasaki

Beaumont²,

Workman³

et al. 2020

IJMS

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This study examined the biological activities of copaiba essential oil via measurement of its effects on signaling pathways in the SH-SY5Y neuronal cell line. Nanofluidic proteomic technologies were deployed to measure the phosphorylation of biomarker proteins within the signaling cascades. Interestingly, copaiba essential oil upregulated the pI3K/Akt/mTOR, MAPK, and JAK/STAT signaling pathways in neuronal cells. The effects of copaiba essential oil peaked at 30 min post-treatment, with a half-maximal effective concentration (EC50) of approximately 80 ng/mL. Treatment with cannabinoid receptor 2 (CB2) agonist AM1241 or the inverse agonist BML190 abrogated the regulatory effects of copaiba essential oil on the pI3K/Akt/mTOR signaling pathway. Surprisingly, copaiba essential oil also activated the apoptosis signaling pathway and reduced the viability of SH-SY5Y cells with an EC50 of approximately 400 ng/mL. Furthermore, β-caryophyllene, a principal constituent of copaiba essential oil, downregulated the pI3K/Akt/mTOR signaling pathway. Taken together, the findings indicated that copaiba essential oil upregulated signaling pathways associated with cell metabolism, growth, immunity, and apoptosis. The biological activities of copaiba essential oil were determined to be fast acting, CB2 mediated, and dependent on multiple chemical constituents of the oil. Nanofluidic proteomics provided a powerful means to assess the biological activities of copaiba essential oil.

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Section: Discussionsupporting

confidence: 79%

Fast-Acting and Receptor-Mediated Regulation of Neuronal Signaling Pathways by Copaiba Essential Oil

Urasaki

Beaumont²,

Workman³

et al. 2020

IJMS

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“…Studies with β-caryophyllene present in copaiba oil have been demonstrating its antiinflammatory properties and its therapeutic effects. 4 Therefore, the use of copaiba oil extracted from trees with low βcaryophyllene concentration may compromise the results of the studies. 3 Another component from copaiba oil with potent antioxidant and anti-inflammatory properties is kaurenoic acid.…”

Section: Resultsmentioning

confidence: 99%

“…5 Currently, the most common use of copaiba oil is topical. 4 Other, newer studies are being performed to find other forms of administration. 6,7 In vitro experiments have shown direct damage to the DNA of cancerous stomach cells with the administration of copaiba oil.…”

Section: Introductionmentioning

confidence: 99%

Meta-analysis on Copaiba Oil: Its Functions in Metabolism and Its Properties as an Anti-inflammatory Agent

et al. 2018

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Recent studies demonstrated that one of the major components of the copaiba oil, β-caryophyllene, has an anti-inflammatory effect. 4 Copaiba oil is extracted from the copaifera, a Abstract Many medicinal plants are sought as alternative therapies for various conditions, as opposed to synthetic alternatives. The Brazilian Amazon provides a plethora of plants with various therapeutic and medicinal properties. One of them is copaiba oil, a natural product of the biodiversity of the Amazon. The anti-inflammatory and antimicrobial properties of copaiba oil have been drawing the attention of the scientific community as a great alternative in the treatment of illnesses associated with inflammatory and infectious processes. The purpose of the present study is to evaluate and analyze the latest publications on the use of copaiba oil in the PubMed/Medline database from 2014 to 2017. Forty-two articles were collected, verifying anti-inflammatory activity, antimicrobial activity, healing, and antitumor activity. The results found on researches with copaiba oil according to publication dates were 11.9% in 2014, 38.1% in 2015, 16.7% in 2016, and 33.3% in 2017. In the analyzed studies, the proposed administration of copaiba oil was 50% topical, 28.6% oral, 9.5% enteral, 4.8% subcutaneous, and 7.1% others. In the objectives of the presente study in relation to the administration of copaiba oil, the result was 31% antimicrobial, 28.6% anti-inflammatory, 9.5% antitumor, 9.5% healing, and 21% others. Regarding the types of research, we have found 50% in vitro, 40.4% in vivo animals, 2.4% in vivo human, 2.4% review and 4.8% others. Regarding the significance factor evaluation, the result was 100% positive in antitumor activity, 84% positive in infection and inflammation pathology, 62% positive in others, like dental processes, food technology application support and as a drug absorption vehicle, and 50% in healing. The results presented in the current meta-analysis show that copaiba oil is an effective alternative to treatments of illnesses such as chronic inflammation, infectious diseases, various types of cancer, autoimmune diseases, and as a vehicle for the absorption of other drugs. Thus, more studies regarding the benefits of copaiba oil could provide a great contribution to the medical community in the treatment of the aforementioned illnesses.

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“…After spreading of this NEs with NO on penis skin of the middle aged dogs, blood NOx concentration in the penis increased, resulting in penile erection without any notable topical and systemic side effects, suggesting that such W/O NEs could be used in non-invasive medication for patients suffering in erectile dysfunction with low response to phophodiesterase type 5 (PDE5) inhibitors such as Viagra or Cialis. Formulations of hydrogels containing negatively or positively charged Copaiba oil NEs exhibited anti-inflammatory effects, which was reflected in mouse ear edema (69 and 67%) and rat paw edema inhibition (32 and 72%) and decrease of inflammatory factors, such as dermis and epidermis hyperplasia and inflammatory cells infiltration in histological cuts were estimated as well (Lucca et al 2018). Skin permeation with the positively charged Copaiba oil NEs increased threefold the retention of the major component in copaiba oil, β-caryophyllene, in the epidermis, and also in the receptor fluid compared to the negatively charged NEs (Lucca et al 2017).…”

Section: Transdermal Nanoemulsion Formulationsmentioning

confidence: 99%

Bio-Based Nanoemulsion Formulations Applicable in Agriculture, Medicine, and Food Industry

Jampílek

Kráľová

Campos

et al. 2019

Nanobiotechnology in Bioformulations

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Nanotechnology providing "a new dimension" accompanied with new properties conferred to many current materials is widely used for production of a new generation of agrochemicals, in medicine it enables improved drug bioavailability, reducing undesirable side effects, minimizing non-specific uptake and specific targeting to certain target cells, while in food industry it has great importance in food protection and biofortification of food with valuable ingredients. In biobased nanoemulsions belonging to lipid nanocarriers plant oils used for oil phase, emulsifiers, biosurfactants, cosurfactants, targeting ligands on the surface of nanoemulsion (e.g., folate) or encapsulated active ingredients are of natural origin. The biocomponents of such nanoemulsions show low toxicity to living organisms, could protect encapsulated compounds for degradation, ensure their sustainable release and reduce the amount of active ingredient necessary for required effect. This chapter presents a comprehensive current overview of recent findings in the field of nanoemulsions and their utilization in agriculture and food industry, with the main emphasis on formulations encapsulating essential oils or plant extracts suitable as effective pesticide preparations as well as medicinal applications of bio-based nanoemulsions, where attention is paid to transdermal nanoemulsion formulations, the use of nanoemulsions in cancer therapy and for pulmonary and ocular drug delivery. Nanoemulsions formulated with natural emulsifiers, biosurfactants and biopolymers are presented and bio-based nanoemulsions of essential oils and their constituents as well as nanoemulsions with encapsulated vitamins, fatty acids and some bioactive compounds are discussed. Applications of nanoemulsions in edible coatings are outlined as well.

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Anti-inflammatory Effect from a Hydrogel Containing Nanoemulsified Copaiba oil (Copaifera multijuga Hayne)

Cited by 37 publications

References 28 publications

Fast-Acting and Receptor-Mediated Regulation of Neuronal Signaling Pathways by Copaiba Essential Oil

Fast-Acting and Receptor-Mediated Regulation of Neuronal Signaling Pathways by Copaiba Essential Oil

Meta-analysis on Copaiba Oil: Its Functions in Metabolism and Its Properties as an Anti-inflammatory Agent

Bio-Based Nanoemulsion Formulations Applicable in Agriculture, Medicine, and Food Industry

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