Fast-Acting and Receptor-Mediated Regulation of Neuronal Signaling Pathways by Copaiba Essential Oil

Urasaki, Yasuyo; Beaumont, Cody; Workman, Michelle; Talbot, Jeffery N.; Hill, D. K.; Le, Thuc T.

doi:10.3390/ijms21072259

Cited by 19 publications

(15 citation statements)

References 56 publications

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“…Copaíba (Copaifera spp.) essential oil (CO) is one of those essential oils approved as a flavoring agent in food and beverages [9] and, is widely distributed in northern South America, and produced in the Brazilian Amazon rainforest, and its main bioactive components are phenolic compounds, such as sesquiterpenes and diterpenes [10], the main component being β karyophylene, which constitutes more than 50% of the oil, selectively binds to the cannabinoid receptor 2 (CB2) and has been proposed as a viable strategy to relieve pain and inflammation [11,12].…”

Section: Introductionmentioning

confidence: 99%

Effect of copaíba essential oil (Copaifera officinalis L.) as a natural preservative on the oxidation and shelf life of sheep burgers

et al. 2021

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We evaluated the effects of the inclusion of copaíba (Copaifera officinalis L.) essential oil at 0.05 and 0.1% as a possible replacement of synthetic additive butylated hydroxytoluene (BHT) in sheep burgers during 14 days of storage in a refrigerated display case (4°C). During the shelf life days, analyzes of antioxidant activity, lipid oxidation, pH, color, cooking loss, texture and consumer acceptability were carried out on refrigerated burgers. The addition of copaíba essential oil showed an antioxidant effect in sheep burgers (P > 0.05), reducing lipid oxidation. Copaiba essential oil added at 0.05% showed the highest antioxidant activity, decreased cooking losses and delaying discoloration (loss of redness) during storage; it further improved, the tenderness of sheep burgers (P < 0.05). The treatments had no effect (P > 0.05) on consumer acceptability. Copaiba essential oil is a promising natural antioxidant to increase the shelf life of meat products, as well as being a viable solution to replace synthetic antioxidant BHT, thereby promoting the fresh‐like quality appeal of sheep burgers.

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Section: Introductionmentioning

confidence: 99%

Effect of copaíba essential oil (Copaifera officinalis L.) as a natural preservative on the oxidation and shelf life of sheep burgers

et al. 2021

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“…In addition, we described distinctive action mechanisms and kinetics of cannabidiol (CBD) oil and copaiba essential oil. Whereas CBD oil had slow and negative regulatory effects, copaiba essential oil had fast and positive regulatory effects on multiple signaling pathways in SH-SY5Y neuronal cells [19,20]. Most surprisingly, we reported that copaiba essential oil had positive regulatory effects on the pI3K/Akt/mTOR signaling pathway in SH-SY5Y neuronal cells, but negative regulatory effects on this pathway in HepG2 liver cells [18,20].…”

Section: Introductionmentioning

confidence: 64%

“…Whereas CBD oil had slow and negative regulatory effects, copaiba essential oil had fast and positive regulatory effects on multiple signaling pathways in SH-SY5Y neuronal cells [19,20]. Most surprisingly, we reported that copaiba essential oil had positive regulatory effects on the pI3K/Akt/mTOR signaling pathway in SH-SY5Y neuronal cells, but negative regulatory effects on this pathway in HepG2 liver cells [18,20]. The pI3K/Akt/mTOR signaling pathway regulates cell growth, proliferation, and metabolism [21,22].…”

Section: Introductionmentioning

confidence: 99%

“…Three Akt isoforms with distinctive functional specificity have been identified in mammals: Akt1, Akt2, and Akt3, which regulate cell proliferation, glucose metabolism, and neuronal development, respectively [23]. SH-SY5Y neuronal cells express all three Akt isoforms [19,20]. In contrast, HepG2 liver cells express only Akt1 and Akt2 [18,20].…”

Section: Introductionmentioning

confidence: 99%

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Akt3 Regulates the Tissue-Specific Response to Copaiba Essential Oil

Urasaki

Beaumont²,

Talbot

et al. 2020

IJMS

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This study reports a relationship between Akt3 expression and tissue-specific regulation of the pI3K/Akt/mTOR signaling pathway by copaiba essential oil. Akt3, a protein kinase B isoform important for the regulation of neuronal development, exhibited differential expression levels in cells of various origins. In neuronal and microglial cells, where Akt3 is present, copaiba essential oil positively regulated the pI3K/Akt/mTOR signaling pathway. In contrast, in liver cells and T lymphocytes, where Akt3 is absent, copaiba essential oil negatively regulated the pI3K/Akt/mTOR signaling pathway. The expression of Akt3 via plasmid DNA in liver cells led to positive regulatory effects by copaiba essential oil on the pI3K/Akt/mTOR signaling pathway. In contrast, inhibition of Akt3 expression in neuronal cells via small interfering RNA molecules targeting Akt3 transcripts abrogated the regulatory effects of copaiba essential oil on the pI3K/Akt/mTOR signaling pathway. Interestingly, Akt3 expression did not impact the regulatory effects of copaiba essential oil on other signaling pathways. For example, copaiba essential oil consistently upregulated the MAPK and JAK/STAT signaling pathways in all evaluated cell types, independent of the Akt3 expression level. Collectively, the data indicated that Akt3 expression was required for the positive regulatory effects of copaiba essential oil, specifically on the pI3K/Akt/mTOR signaling pathway.

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“…Briq. (Ng et al, 2018), and copaiba oil (Urasaki et al, 2020), in which it exerts immunomodulatory activity. Taken together, the studies demonstrate that CB2R play a key role in balancing the immune response and BCP by activating CB2R, holding promise in the therapeutic modulation of immuneinflammatory changes in patients with SARS-CoV-2 infection.…”

Section: Immunomodulatory Properties Of Bcpmentioning

confidence: 99%

β-Caryophyllene, A Natural Dietary CB2 Receptor Selective Cannabinoid can be a Candidate to Target the Trinity of Infection, Immunity, and Inflammation in COVID-19

et al. 2021

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Coronavirus disease (COVID-19), caused by novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is an ongoing pandemic and presents a public health emergency. It has affected millions of people and continues to affect more, despite tremendous social preventive measures. Identifying candidate drugs for the prevention and treatment of COVID-19 is crucial. The pathogenesis and the complications with advanced infection mainly involve an immune-inflammatory cascade. Therefore, therapeutic strategy relies on suppressing infectivity and inflammation, along with immune modulation. One of the most promising therapeutic targets for the modulation of immune-inflammatory responses is the endocannabinoid system, particularly the activation of cannabinoid type 2 receptors (CB2R), a G-protein coupled receptor which mediates the anti-inflammatory properties by modulating numerous signaling pathways. To pharmacologically activate the CB2 receptors, a naturally occurring cannabinoid ligand, beta-caryophyllene (BCP), received attention due to its potent anti-inflammatory, antiviral, and immunomodulatory properties. BCP is recognized as a full selective functional agonist on CB2 receptors and produces therapeutic effects by activating CB2 and the nuclear receptors, peroxisome proliferator-activated receptors (PPARs). BCP is regarded as the first dietary cannabinoid with abundant presence across cannabis and non-cannabis plants, including spices and other edible plants. BCP showed tissue protective properties and favorably modulates numerous signaling pathways and inhibits inflammatory mediators, including cytokines, chemokines, adhesion molecules, prostanoids, and eicosanoids. Based on its pharmacological properties, molecular mechanisms, and the therapeutic potential of BCP as an immunomodulator, anti-inflammatory, organ-protective, and antiviral, we hypothesize that BCP could be a promising therapeutic and/or preventive candidate to target the triad of infection, immunity, and inflammation in COVID-19. In line with numerous studies that proposed the potential of cannabinoids in COVID-19, BCP may be a novel candidate compound for pharmaceutical and nutraceutical development due to its unique functional receptor selectivity, wide availability and accessibility, dietary bioavailability, nonpsychoactivity, and negligible toxicity along with druggable properties, including favorable pharmacokinetic and physicochemical properties. Based on reasonable pharmacological mechanisms and therapeutic properties, we speculate that BCP has potential to be investigated against COVID-19 and will inspire further preclinical and clinical studies.

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Fast-Acting and Receptor-Mediated Regulation of Neuronal Signaling Pathways by Copaiba Essential Oil

Cited by 19 publications

References 56 publications

Effect of copaíba essential oil (Copaifera officinalis L.) as a natural preservative on the oxidation and shelf life of sheep burgers

Effect of copaíba essential oil (Copaifera officinalis L.) as a natural preservative on the oxidation and shelf life of sheep burgers

Akt3 Regulates the Tissue-Specific Response to Copaiba Essential Oil

β-Caryophyllene, A Natural Dietary CB2 Receptor Selective Cannabinoid can be a Candidate to Target the Trinity of Infection, Immunity, and Inflammation in COVID-19

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