Anti‐inflammatory Dietary Supplements in the Chemoprevention of Oral Cancer.

Hari, Shri; Vasudevan, Vijeev; Kasibhotla, Soundarya; Reddy, D. Ravi Sankar; Venkatappa, Manjunath; Devaraju, D

doi:10.17980/2016.380

Cited by 14 publications

(11 citation statements)

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“…Antiproliferative agents, also known as suppressing agents, are able to effectively block or retard carcinogenesis progression, acting through different mechanisms, such as the alteration of metabolic function of cancerous clones, apoptosis induction, inhibition of prosurvival signalings, modulation of growth hormone activity, block of DNA synthesis, and stimulation of terminal differentiation, thus leading to the arrest of proliferation and cell death [ 236 ]. As several inflammatory factors are dysregulated in cancers, anti-inflammatory agents have been approached as possible alternative strategies to suppress cancer progression [ 237 , 238 ]. Moreover, targeting the prosurvival signalings of cytokines and immune response has been highlighted as a promising antiproliferative strategy, too [ 238 ].…”

Section: Caryophyllane Sesquiterpenes In Cancer Chemopreventionmentioning

confidence: 99%

Chemopreventive Potential of Caryophyllane Sesquiterpenes: An Overview of Preliminary Evidence

Sotto

Mancinelli

Gullì

et al. 2020

Cancers

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Chemoprevention is referred to as a strategy to inhibit, suppress, or reverse tumor development and progression in healthy people along with high-risk subjects and oncologic patients through using pharmacological or natural substances. Numerous phytochemicals have been widely described in the literature to possess chemopreventive properties, although their clinical usefulness remains to be defined. Among them, caryophyllane sesquiterpenes are natural compounds widely occurring in nature kingdoms, especially in plants, fungi, and marine environments. Several structures, characterized by a common caryophyllane skeleton with further rearrangements, have been identified, but those isolated from plant essential oils, including β-caryophyllene, β-caryophyllene oxide, α-humulene, and isocaryophyllene, have attracted the greatest pharmacological attention. Emerging evidence has outlined a complex polypharmacological profile of caryophyllane sesquiterpenes characterized by blocking, suppressing, chemosensitizing, and cytoprotective properties, which suggests a possible usefulness of these natural substances in cancer chemoprevention for both preventive and adjuvant purposes. In the present review, the scientific knowledge about the chemopreventive properties of caryophyllane sesquiterpenes and the mechanisms involved have been collected and discussed; moreover, possible structure–activity relationships have been highlighted. Although further high-quality studies are required, the promising preclinical findings and the safe pharmacological profile encourage further studies to define a clinical usefulness of caryophyllane sesquiterpenes in primary, secondary, or tertiary chemoprevention.

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Section: Caryophyllane Sesquiterpenes In Cancer Chemopreventionmentioning

confidence: 99%

Chemopreventive Potential of Caryophyllane Sesquiterpenes: An Overview of Preliminary Evidence

Sotto

Mancinelli

Gullì

et al. 2020

Cancers

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“…Masuda et al have highlighted that among the many bioactive molecules EGCG seems to be one of the most promising, especially due to its clinical efficacy but also the biological effects on certain lipid layers [31]. EGCG also has been shown to prevent the invasion and metastasis of the OC2 and SCC-9 cells by inhibiting MMP2 and MMP9 matrix metalloproteinase and suppressing urokinase plasminogen activator activity [32,33]. Another study conducted by Irimie et al showed that EGCG can induce the activation of cell death receptors in the case of SCC-4 cells, suggesting the importance potential of the compunds as natural drug candidate [34].…”

Section: In Vitro Tests On Tumoral Cellsmentioning

confidence: 99%

Polyurethane Structures Used as a Drug Carrier for Epigallocatechin Gallate

Marin¹,

Marin²,

Ene³

et al. 2021

Mater. Plast.

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The current study was proposed in order to obtain, to characterize by usually physico-chemical methods and to assess in vitro, the potential cytotoxic effect of polyurethane microstructures loaded with epigallocatechin gallate (PU_MS) on human pharyngeal carcinoma cells (Detroit 562) and squamous cell carcinoma (SCC-4). The results showed that polyurethane microstructures obtained are stable and have dimensions that make them biocompatible with the biological environment. The cytotoxicity of test samples is dependent on concentration and 72 hours after stimulation at the highest concentration tested the viability of tumor cells was below 50%, the decrease being much more pronounced in the case of squamous cell carcinoma. The novel nanostructures loaded with epigallocatechin gallate induced an augmented cytotoxic effect, suggesting that this drug carriers are suitable to enhance the antitumor effect of epigallocatechin gallate.

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“…Chronic inflammatory mediators released from immune cells such as macrophages, lymphocytes, and MDSC are cytokines (IL-6,IL-4,IL-8 and IL-10), growth factors (EGF,FGF,TGF-Beta), transcriptional factors (NF-KB, STAT-3 and HIF-1 ALFA), proteolytic enzymes (MMP-2,9,UPA) and COX-2 are all which drives the genomic instability, cellular proliferation, angiogenesis, resistance to apoptosis, epithelial to mesenchymal transition, invasion, and metastasis [ 33 ]. Identification of inflammatory mediators which promote or prevent the progression of cancer depends on the context of the tumour microenvironment.…”

Section: Inflammatory Mediators Which Promote the Progression Of Cancmentioning

confidence: 99%

Dual role of inflammatory mediators in cancer

Shrihari¹

2017

ecancer

133

116

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Inflammation is the body’s response to noxious stimuli such as infectious, physiological or chemical agents, it releases various inflammatory mediators via immune cells such as neutrophils, macrophages, and lymphocytes. These inflammatory mediators are growth factors, chemokines, and cytokines. Reactive oxygen species (ROS) and nitrogen species (RNS) activate transcriptional factors (NF-KB, STAT-3) and bring about cellular proliferation, genomic instability, angiogenesis, resistance to apoptosis, invasion, and metastasis. The presence of inflammatory mediators in the tumour microenvironment inhibits or promotes inflammation-induced cancer, depending on various stages of immune surveillance of the tumor i.e. by immunoediting, immunoprocessing, and immunoevasion. Myeloid derived suppressor cells are immature myeloid progenitor cells. They are the major immune-suppressor cells in the tumour inflammatory microenvironment that activate transcriptional factor NF-KB, STAT-3 to bring about tumour progression. Another gene which the micro RNA’s are noncoding RNA molecules is found to have a link with inflammation and cancer. This article discusses the roles of inflammatory mediators involved in antitumour or protumour activity within the context of the tumour microenvironment.

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Anti‐inflammatory Dietary Supplements in the Chemoprevention of Oral Cancer.

Cited by 14 publications

References 0 publications

Chemopreventive Potential of Caryophyllane Sesquiterpenes: An Overview of Preliminary Evidence

Chemopreventive Potential of Caryophyllane Sesquiterpenes: An Overview of Preliminary Evidence

Polyurethane Structures Used as a Drug Carrier for Epigallocatechin Gallate

Dual role of inflammatory mediators in cancer

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