Anti‐inflammatory, antioxidant effects, and bioaccessibility of Tigzirt propolis

Boufadi, Mokhtaria Yasmina; Soubhye, Jalal; Antwerpen, Pierre Van

doi:10.1111/jfbc.13663

Cited by 12 publications

(7 citation statements)

References 35 publications

(41 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nedji & Loucif-Ayad [12] have proved the effectiveness of propolis from Annaba against foodborne pathogens and attributed the strong antimicrobial activity to high total phenolic and flavonoid contents. Some other biological and pharmacological properties of Algerian propolis have been noted such as antitumor, anti-inflammatory, wound healing, immunomodulatory and neuroprotective [7,10,[13][14][15][16]. Only two research exist on the anti-Alzheimer effect of Algerian propolis from Grarem and Djebel-El-ouahch regions [7,16], which have distinct geographical and botanical origins from the samples used in the current study.…”

Section: Introductionmentioning

confidence: 89%

Anticholinesterase, anti-α-glucosidase, antioxidant and antimicrobial effects of four Algerian propolis

et al. 2021

View full text Add to dashboard Cite

This study aimed to investigate the functional properties of four Algerian propolis collected from El-Menia, Oum el Bouaghi, El Harrouch and Collo regions. The total bioactive content, antioxidant, anti-enzymatic and antimicrobial effects of the four propolis methanolic extracts were evaluated using in vitro assays. The highest amount of total phenolic (561.99 ± 3.50 μg GAE/mg E) and flavonoid content (76.98 ± 0.26 μg QE/mg E) was found in propolis from El-Menia. Antioxidant tests (DPPH, ABTS, CUPRAC and ferric reducing power) revealed the strong scavenging and reducing abilities of the extracts. Anti-enzymatic assays against acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and α-glucosidase showed that all extracts possessed a potent inhibitory effect on α-glucosidase better than acarbose and revealed the ability of extracts to inhibit BChE more effectively than AChE. However, the extract of propolis from El Menia was the best inhibitor of the three key enzymes with IC 50 values of 11.40 ± 0.58 µg/mL 16.06 ± 0.85 µg/mL and 71.29 ± 2.73 µg/mL against α-glucosidase, BChE and AChE, respectively. The antimicrobial assay indicated that all extracts were mainly active against Gram-positive bacteria and yeast and had bactericidal action in certain bacteria and bacteriostatic action in other ones. However, they had all fungistatic effect on C. albicans ATCC 10231. According to these results, Algerian propolis can be considered as a source of natural bioactive principles for dietary, pharmacological and medicinal applications.

show abstract

Section: Introductionmentioning

confidence: 89%

Anticholinesterase, anti-α-glucosidase, antioxidant and antimicrobial effects of four Algerian propolis

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Moreover, the content of total phenols and flavonoids/flavonols in the sample was high, so it has strong antioxidant and antibacterial properties [ 90 ]. When Tigzirt propolis was tested for anti-inflammatory and antioxidant effects, it was found that propolis extract helped to reduce PGE2 and TNF- α 、Myeloperoxidase and malondialdehyde levels, and increase the total antioxidant level in plasma [ 91 ].…”

Section: The Possible Mechanism Of Propolis On Wound Healingmentioning

confidence: 99%

Research Progress on Therapeutic Effect and Mechanism of Propolis on Wound Healing

Yang

Yan

et al. 2022

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Propolis is a kind of reduct collected by bees from various plant sources. Because propolis is a mixture, it has a variety of biological activities, excellent anti-inflammatory and bactericidal effects. Especially in the treatment of infectious wounds, acute wounds, burns, and scalds and promoting wound healing, more and more scientists began to apply it to the research field of wound healing. The standard preparation of propolis combined with other compound components has a safer and less toxic effect in the treatment of trauma. In order to more effectively use propolis products in wound treatment. This paper reviews the effect and treatment mechanism of propolis on different types of wound healing, as well as the synergistic effect of propolis and other compounds, in order to provide ideas for the further exploration of the biological activity and pharmacological function of propolis in the future, as well as its in-depth development in the field of wound healing. It will also provide a theoretical reference for the further development and utilization of propolis.

show abstract

“…In particular, the authors demonstrated that propolis is able to both reduce the release of myeloperoxidase from neutrophils and directly inhibit its activity. 149 The immunomodulatory properties of Moroccan propolis, mainly characterized by pinocembrin, chrysin, quercetin, and galangin, were evaluated in vitro by Touzani et al 150 Propolis extract alone showed no effect on the production of TNF-α and IL-6, as well as IL-10, in human PBMCs. However, when PBMCs were stimulated with LPS, propolis significantly inhibited the secretion of TNF-α and IL-6, which at a concentration of 250 μg/mL declined toward basal levels, whereas IL-10 production was strongly enhanced in a concentration-dependent manner, thus indicating a selective anti-inflammatory and pro-resolving effect on activated immune cells.…”

Section: Other Propolismentioning

confidence: 99%

“…Moreover, propolis reduced the levels of PGE‐2 and TNF‐α and the activity of myeloperoxidase in the peritoneal exudate. In particular, the authors demonstrated that propolis is able to both reduce the release of myeloperoxidase from neutrophils and directly inhibit its activity 149 …”

Section: Immunomodulatory Activitymentioning

confidence: 99%

See 1 more Smart Citation

The antiviral and immunomodulatory activities of propolis: An update and future perspectives for respiratory diseases

Magnavacca

Sangiovanni

Racagni

et al. 2021

Medicinal Research Reviews

View full text Add to dashboard Cite

Propolis is a complex natural product that possesses antioxidant, anti‐inflammatory, immunomodulatory, antibacterial, and antiviral properties mainly attributed to the high content in flavonoids, phenolic acids, and their derivatives. The chemical composition of propolis is multifarious, as it depends on the botanical sources from which honeybees collect resins and exudates. Nevertheless, despite this variability propolis may have a general pharmacological value, and this review systematically compiles, for the first time, the existing preclinical and clinical evidence of propolis activities as an antiviral and immunomodulatory agent, focusing on the possible application in respiratory diseases. In vitro and in vivo assays have demonstrated propolis broad‐spectrum effects on viral infectivity and replication, as well as the modulatory actions on cytokine production and immune cell activation as part of both innate and adaptive immune responses. Clinical trials confirmed propolis undeniable potential as an effective therapeutic agent; however, the lack of rigorous randomized clinical trials in the context of respiratory diseases is tangible. Since propolis is available as a dietary supplement, possible use for the prevention of respiratory diseases and their deleterious inflammatory drawbacks on the respiratory tract in humans is considered and discussed. This review opens up new perspectives on the clinical investigation of neglected propolis biological properties which, now more than ever, are particularly relevant with respect to the recent outbreaks of pandemic respiratory infections.

show abstract

Anti‐inflammatory, antioxidant effects, and bioaccessibility of Tigzirt propolis

Cited by 12 publications

References 35 publications

Anticholinesterase, anti-α-glucosidase, antioxidant and antimicrobial effects of four Algerian propolis

Anticholinesterase, anti-α-glucosidase, antioxidant and antimicrobial effects of four Algerian propolis

Research Progress on Therapeutic Effect and Mechanism of Propolis on Wound Healing

The antiviral and immunomodulatory activities of propolis: An update and future perspectives for respiratory diseases

Contact Info

Product

Resources

About