Research Progress on Therapeutic Effect and Mechanism of Propolis on Wound Healing

Abstract

Propolis is a kind of reduct collected by bees from various plant sources. Because propolis is a mixture, it has a variety of biological activities, excellent anti-inflammatory and bactericidal effects. Especially in the treatment of infectious wounds, acute wounds, burns, and scalds and promoting wound healing, more and more scientists began to apply it to the research field of wound healing. The standard preparation of propolis combined with other compound components has a safer and less toxic effect in the treatment of trauma. In order to more effectively use propolis products in wound treatment. This paper reviews the effect and treatment mechanism of propolis on different types of wound healing, as well as the synergistic effect of propolis and other compounds, in order to provide ideas for the further exploration of the biological activity and pharmacological function of propolis in the future, as well as its in-depth development in the field of wound healing. It will also provide a theoretical reference for the further development and utilization of propolis.

Honey and propolis for wound healing

“…Wound healing is a recovering process of damaged tissues by replacing dysfunctional injured cellular structures. 1 occurred through three main phases; inflammation, proliferative, and tissue remodeling 2 to form a complex and continuous process but dynamic and orderly process, characterized by a series of overlapping of these interact phases. Honey is one of the oldest known medicines which have been "rediscovered" in later times by the medical profession, especially for dressing wounds management since its effectiveness.…”

“…23 It was found that propolis can decrease scar formation, shorten healing time, boost wound contraction, accelerate tissue repair, and ultimately improve patients' quality of life in skin wound healing. 2 Otherwise, the release of honeypropolis-engineered collagen peptides in the wound site increases the absorption and re-epithelization of keratinocytes. 10 Reducing bacterial biofilm production: Biofilm production is a passive virulence factor facilitating many infectious diseases 79 where certain bacterial genes produce extracellular polysaccharides to protect these pathogens from antimicrobial agents and cellular immune elements 80 resulting in long standing chronic wounds.…”

Honey-Propolis-Engineered Collagen Peptides as Promising Wound-Healing Matrix in Mouse Model

“…Propolis is believed to have antibacterial, anti-inflammatory, antiseptic, antimycotic, anesthetic, spasmolytic, antifungal, antiulcer, anticancer, and immunomodulatory properties [ 13 , 15 ], as well as wound-healing properties. It can decrease scar formation, shorten healing time, boost wound contraction, accelerate tissue repair, and ultimately improve patients’ quality of life in skin wound healing [ 16 ]. More than 300 different compounds were characterized so far, including aliphatic acid, fatty acids, ketones, terpenoids, vitamins, etc.…”

Neutrophil Immunomodulatory Activity of Nerolidol, a Major Component of Essential Oils from Populus balsamifera Buds and Propolis

“…Propolis has been used by humans therapeutically to treat inflammation and infectious diseases [ 3 , 4 , 5 , 6 , 7 , 8 ]. Numerous studies have revealed a range of biological activities of propolis, including antibacterial, antifungal, antiviral, anticancer, anti-inflammatory, immunomodulatory, and antioxidant activities [ 9 , 10 , 11 , 12 , 13 , 14 , 15 ]. Although the anti-inflammatory and immunomodulatory activities of propolis are well established (reviewed in [ 16 , 17 ]), it is still unclear how propolis components could contribute to all of these biological properties.…”