Anti-inflammatory, antinociceptive and antipyretic effects of some desert plants

Awaad, Amani S.; El‐Meligy, Reham M.; Qenawy, S.A.; Atta, Attia H.; Soliman, Gamal A.

doi:10.1016/j.jscs.2011.02.004

Cited by 65 publications

(54 citation statements)

References 16 publications

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“…In addition, the mice were alive during the whole 48 h of observation. Accordingly, it is suggested that the oral median lethal doses (LD 50 ) of the alcoholic extracts of the three plants were higher than 4000 mg/kg [45].…”

Section: Acute Toxicity (Ld 50 )mentioning

confidence: 99%

The Pharmacological Activity of Some Tamaricaceae Plants

Al-Jaber¹,

Allehaib²

2017

Nat Prod Chem Res

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The antipyretic activity of the alcoholic extracts for the Tamarix aucheriana, T. nilotica, and T. aphylla were measured in the Wistar albino male rats (150-180 g) by using a yeast-induced hyperpyrexia test. The carrageenaninduced paw edema method. The anti-inflammatory activity of the T. aucheriana, T. nilotica, and T. aphylla extracts was measured. The edema was expressed as an increase in paw volume. The analgesic activity of the alcoholic extracts of the T. aucheriana, T. nilotica, and T. aphylla were implemented in the Swiss albino mice by using acetic acid induced writhing and hot plate methods.

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Section: Acute Toxicity (Ld 50 )mentioning

confidence: 99%

The Pharmacological Activity of Some Tamaricaceae Plants

Al-Jaber¹,

Allehaib²

2017

Nat Prod Chem Res

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“…In spite of the differences found between the two techniques and the advantages that offer HS-SPME, most pharmacopeias require the analysis of the essential oils prepared by hydrodistillation for quality control purposes. The crude drug of C. filaginoides possesses high amounts of rutin (1) and its hydrolysis products (2 and 3), which are multi-target constituents with antidiabetic (Kamalakkannan & Mainzen, 2006;Kwon et al, 2007;Rauter et al, 2010), analgesic (Awaad et al, 2011;Lapa et al, 2009;Rad et al, 2008), anti-inflammatory (Yildizoglu-Ari et al, 1991) and smooth muscle relaxant properties (Mata et al, 1997), among others.…”

Section: Discussionmentioning

confidence: 99%

Quality control tests for the crude drug ofConyza filaginoides

Ovalle-Magallanes

Rivero‐Cruz

Mata

2013

Pharmaceutical Biology

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Context: Conyza filaginoides (D.C.) Hieron (Asteraceae) is a medicinal Mexican plant highly prized in contemporary Mexico for the treatment of upset stomach and diabetes. Objective: This work was undertaken to develop a suitable high performance liquid chromatography (HPLC)-diode array detection (DAD) method for quantifying rutin (1), the main active principle from the aerial parts of C. filaginoides. Materials and methods: The method was performed using a LiChrospher 100 RP-18 column. The mobile phase was water (containing 0.1% phosphoric acid)-methanol-acetonitrile (80:5:15, v/v) at a flow rate of 1.2 mL min À1. Results: Limits of detection and quantification were 7.5 and 22.8 mg mL À1, respectively. The main recoveries measured at three concentrations were higher than 98%, with RSD 52%. Quantitative analysis of a few samples showed the presence of high concentrations of 1 (3.6 AE 0.2 g/100 g of dry plant material). The volatile components were extracted by hydrodistillation or head space solid-phase microextraction (HS-SPME), and thereafter analyzed by gas chromatography coupled to mass spectrometry (GC-MS). Forty-three chemical constituents representing 90% of the total content of the oil were identified. The major light volatile compounds obtained by HS-SPME revealed a high content of monoterpene hydrocarbons.Conclusions: A precise, reliable, and accurate analytical HPLC method to detect and quantify 1 in the crude drug and some preparations were developed and fully validated. The volatile components of the plant are described for the first time. The proposed method would be useful for quality control assurance of this important Mexican plant.

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“…The plant is used in the treatment of diseases of the liver and urinary tract, and also as a laxative (7). Oil extracted from the leaves is applicable for the treatment of rheumatism, and the flowers are used for warts and migraines (8). A study by Sulaiman showed that this plant has anti-bacterial properties (9).…”

Section: Introductionmentioning

confidence: 99%