The Pharmacological Activity of Some Tamaricaceae Plants

Al-Jaber, Nabila A.; Allehaib, Lamya

doi:10.4172/2329-6836.1000262

Cited by 5 publications

(4 citation statements)

References 21 publications

(25 reference statements)

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“…Therefore, it can be concluded that the dose of 4000 mg/kg was well-tolerated and did not produce any toxicological changes in the physical condition and appearance of the rats. These findings are consistent with previous studies, which reported that LD50 of TA is above 1500 mg/kg BW, and revealed that the methanolic extract of TA produced no toxic symptoms in graded doses up to 4000 mg/kg in acute and sub-chronic toxicity studies [ 28 , 29 ]. Based on OECD guidelines for testing chemicals, the methanolic extract of TA was considered safe [ 30 ].…”

Section: Discussionsupporting

confidence: 93%

Involvement of TNFα, IL-1β, COX-2 and NO in the anti-inflammatory activity of Tamarix aphylla in Wistar albino rats: an in-vivo and in-vitro study

Fayez,

Khalil,

Abdel-Sattar

et al. 2024

BMC Complement Med Ther

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Background With the emergence of many side effects from synthetic drugs, there is an urgent need to find a natural alternative to these products. Therefore, our primary aim was to evaluate the anti-inflammatory activity of Tamarix aphylla (TA) and investigate the potential mechanism underlying this action. Methods Initially, to ensure the safety of the extract and for dose selection, we performed an acute oral toxicity Assay through the oral administration of graded doses up to 4 g\kg in Wistar rats. then, we used the carrageenan-induced edema model to elucidate the anti-inflammatory activity. Using specific ELISA kits, we measured the levels of TNF-α, IL-1β, COX-2 and NO inside the inflamed paw tissue. Finally, for the in-vitro anti-inflammatory experiment, we used the erythrocyte membrane stability test. Results Based on the acute oral toxicity assay, T. aphylla was considered generally safe and three different doses of 100, 200, and 400 mg/kg were chosen for further experiments. Additionally, TA expressed a significant (P < 0.05) anti-inflammatory activity, showing the maximum inhibition percentage at the fifth hour of measurement at 53.47% and 70.06%, at doses of 200 and 400 mg/kg respectively, compared to 63.81% for the standard drug. Similarly, we found that TA effectively reduced the levels of TNF-α and IL-1β at all tested doses (100-200-400 mg/kg) to a greater extent than the standard drug. Moreover, at 400 mg/kg, TA was able to significantly lower the levels of COX-2 and NO inside the inflamed tissue to a level comparable (P < 0.05) with that measured inside the paw tissue of normal rats. Finally, Tamarix aphylla at 100, 200 and 400 mg/kg doses significantly (P < 0.05) inhibited the heat-induced hemolysis of RBCs membrane by 67.78, 74.82 and 82.08%, respectively, compared to 83.89% produced by Aspirin. Conclusion T. aphylla produced a significant (P < 0.05) anti-inflammatory activity compared to the standard drugs either through the reduction of pro-inflammatory mediators or the protection of the lysosomal membrane.

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Section: Discussionsupporting

confidence: 93%

Involvement of TNFα, IL-1β, COX-2 and NO in the anti-inflammatory activity of Tamarix aphylla in Wistar albino rats: an in-vivo and in-vitro study

Fayez,

Khalil,

Abdel-Sattar

et al. 2024

BMC Complement Med Ther

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“…Yusufoglu and Alqasoumi (2011), who evaluated the wound healing activity of T. aphylla extract using the excision wound model to monitor wound contraction and wound closure time, reported that the plant extract accelerated the wound healing process by reducing wound contraction and wound half closure time. The use of the bark of T. aphylla to treat hepatitis, an inflammation of the liver caused by viruses, was also reported previously (Akhlaq & Mohammed, 2011;Nawwar et al, 2009) but was not confirmed in in vivo studies; hence, the plant extract has shown antioxidant activity (Mahfoudhi, Ben Salem, et al, 2016;Qadir et al, 2014) and a significant anti-inflammatory effect when tested in Wister albino rats using a carrageenaninduced paw edema test (Al-Jaber & Allehaib, 2017;Iqbal et al, 2017). A significant proportion of the respondents reported the use of T. aphylla leaves to relieve joint pain, headache, and rheumatism.…”

Section: Literature-based Proof Of Biological and Pharmacological Activitiesmentioning

confidence: 73%

“…Antioxidant, analgesic and antipyretic activities (Al-Jaber & Allehaib, 2017;Mahfoudhi, Ben Salem, et al, 2016;Qadir, Abbas, Hamayun, & Ali, 2014). Antidiabetic (Mahfoudhi, Grosso, et al, 2016).…”

Section: Rootmentioning

confidence: 99%

Ethnobotanical, Phytochemical, and Biological Study of Tamarix aphylla and Aerva javanica Medicinal Plants Growing in the Asir Region, Saudi Arabia

Suleiman

2019

Tropical Conservation Science

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In this study, Tamarix aphylla and Aerva javanica, plants used in folkloric medicine in the Asir region of Saudi Arabia were studied ethnobotanically, chemically, and biologically to assess their medicinal uses, phytochemical constituents, and biological activities. Ethnobotanical data were collected using semistructured interviews and the use values were calculated. A total of 61 informants were interviewed and results indicated high-value uses (0.9 and 0.7) for the plants. Phytochemical investigation indicated that the plants contained most of the phytochemicals that were tested for. The antioxidant activity was examined by assaying total phenolic content, 1,1-Diphenyl-2-picrylhydrazyl (DPPH), and hydrogen peroxide (H 2 O 2) radical scavenging activity. .The bark extract of T. aphylla showed the best antioxidant effect in total phenolic content, DPPH, and H 2 O 2 assays (278.02 AE 0.16 mg GAE/100 g; The half-maximal inhibitory concentration (IC 50): DPPH, 18.39 AE 0.62 lg/mL; H 2 O 2 , 252.94 AE 1.86 lg/mL), followed by extract of the A. javanica aerial parts (228.60 AE 2.09 mg GAE/100 g; IC 50 : DPPH, 28.54 AE 0.53 lg/mL; H 2 O 2 , 154.17 AE 0.78 lg/mL) compared with ascorbic acid (DPPH: 27.27 AE 0.11 lg/mL; H 2 O 2 : 164.9 AE 0.37 lg/mL). The disc diffusion method performed for antimicrobial activity revealed weak activities in T. aphylla and A. javanica extracts (100 lg/mL) against six human pathogens. It was concluded that these plants possess therapeutic potential in the treatment of 18 types of ailments, which are important phytochemical constituents and antioxidant activities that justify their therapeutic uses in traditional medicine. Thus, this study laid sufficient background for further pharmacological research on extracts of these plants.

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“…Literature dealing with antiproliferative effect of t. gallica is relatively poor. Nevertheless, many studies reported anti-inflammatory, analgesic antioxidant, antihyperlipidemic, antiviral, cytotoxic, anti-Alzheimer and Type 2 Diabetes Diseases activities [14][15][16][17][18][19][20]…”

Section: C6 Cellsmentioning

confidence: 99%

Anti-proliferative activity of ethyl acetate extracts of Tamarix gallica L. grown at different climatic conditions in Algeria

Fellah

Hameurlaine

Gherraf

et al. 2018

Acta Scientifica Naturalis

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The aerial parts of T. gallica collected from three different locations (arid, humid and semi-arid) were extracted using ethyl acetate. The crude extracts were subjected to phenolic appraisal and antiproliferative activity using ELISA and xCELLigence assays. The total phenolic and flavonoids were evaluated using appropriate techniques to give a yield of total phenolics ranging between 238.46 and 348.56 mg GAE (Gallic acid equivalent)/g dry weight extract. The flavonoids yield was found to vary from 36.6 to 103.14 mg QE (quercetin equivalent)/g dry weight extract. Moreover, the extracts were tested against rat brain tumor (C6) and human cervix carcinoma (HeLa) cell lines and displayed important differences in activity. These disparities highlighted the effect of climatic factors as quality determinants of secondary metabolites and therefore as a key control of the biological therapeutic effect.

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The Pharmacological Activity of Some Tamaricaceae Plants

Cited by 5 publications

References 21 publications

Involvement of TNFα, IL-1β, COX-2 and NO in the anti-inflammatory activity of Tamarix aphylla in Wistar albino rats: an in-vivo and in-vitro study

Involvement of TNFα, IL-1β, COX-2 and NO in the anti-inflammatory activity of Tamarix aphylla in Wistar albino rats: an in-vivo and in-vitro study

Ethnobotanical, Phytochemical, and Biological Study of Tamarix aphylla and Aerva javanica Medicinal Plants Growing in the Asir Region, Saudi Arabia

Anti-proliferative activity of ethyl acetate extracts of Tamarix gallica L. grown at different climatic conditions in Algeria

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