Anti-inflammatory and immunomodulatory effects of baicalin in cerebrovascular and neurological disorders

Li, Yuanyuan; Song, Ke; Zhang, Hanlai; Yuan, Mengchen; An, Na; Wei, Yufei; Wang, Liqin; Sun, Yikun; Xing, Yanwei; Gao, Yonghong

doi:10.1016/j.brainresbull.2020.08.016

Cited by 37 publications

(18 citation statements)

References 90 publications

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“…We have shown that both compounds could inhibit the SARS-CoV-2 RdRp through specific binding, while baicalein showed stronger binding affinity compared to baicalin. These compounds are natural bioactive polyphenolic flavonoid compounds and are widely used in traditional Chinese medicine as a remedy for the treatment of various medical conditions [ 9 , 10 ]. Based on the SARS-CoV-2 antiviral potency and the safety profile of these compounds, we propose further studies on these compounds and structurally related derivatives, alone and also in combination with effective nucleoside analogs such as remdesivir towards generating compelling data to advance an anti-COVID-19 drug candidate for further preclinical studies.…”

Section: Discussionmentioning

confidence: 99%

“…SARS-CoV-2 (NR-52281: USA-WA/2020) was provided by BEI Resources (Manassas, Virginia, VA, USA) and propagated in Vero cells followed by Interestingly, we have already shown in different studies that these compounds can inhibit other emerging RNA viruses such as dengue virus (DENV), Zika virus (ZIKV) and Chikungunya virus (CHIKV) [4][5][6][7][8]. Baicalein and baicalin are natural bioactive phenolic flavonoid compounds and are primarily available from the root of Scutellaria baicalensis Georgi (Huang Qin), an East Asian skullcap plant that contains abundant flavonoids, which are widely used in traditional Chinese medicine as a remedy for the clinical treatment of hyperlipidemia, hypertension, atherosclerosis, dysentery, common cold and inflammatory diseases [9,10]. Baicalin is metabolized to baicalein in the intestine.…”

Section: Cells and Virusmentioning

confidence: 99%

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Baicalein and Baicalin Inhibit SARS-CoV-2 RNA-Dependent-RNA Polymerase

Zandi

Musall

et al. 2021

Microorganisms

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Coronavirus Disease 2019 (COVID-19) is a deadly emerging infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Because SARS-CoV-2 is easily transmitted through the air and has a relatively long incubation time, COVID-19 has rapidly developed into a global pandemic. As there are no antiviral agents for the prevention and treatment of this severe pathogen except for remdesivir, development of antiviral therapies to treat infected individuals remains highly urgent. Here, we showed that baicalein and baicalin exhibited significant antiviral activity against SARS-CoV-2, the causative agent of COVID-19 through in vitro studies. Our data through cell-based and biochemical studies showed that both compounds act as SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) inhibitors directly and inhibit the activity of the SARS-CoV-2 RdRp, but baicalein was more potent. We also showed specific binding of baicalein to the SARS-CoV-2 RdRp, making it a potential candidate for further studies towards therapeutic development for COVID-19 as a selective non-nucleoside polymerase inhibitor.

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Section: Discussionmentioning

confidence: 99%

Section: Cells and Virusmentioning

confidence: 99%

Baicalein and Baicalin Inhibit SARS-CoV-2 RNA-Dependent-RNA Polymerase

Zandi

Musall

et al. 2021

Microorganisms

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“…Baicalin (Ba) and aglycon baicalin are the principal flavonoid derivatives obtained from the roots of S. baicalensis , and they possess structural similarities ( de Oliveira et al, 2015 ). Ba, with anti-inflammatory and immunomodulatory properties, plays a tremendous role in neuroinflammatory diseases ( Li et al, 2020a ). At present, the latest technology used to extract baicalin is the deep eutectic solvent ultra-high pressure method ( Hao et al, 2020 ).…”

Section: Nature Productsmentioning

confidence: 99%

Role of Plant-Derived Natural Compounds in Experimental Autoimmune Encephalomyelitis: A Review of the Treatment Potential and Development Strategy

et al. 2021

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Multiple sclerosis (MS) is an autoimmune disease of the central nervous system that is mainly mediated by pathological T-cells. Experimental autoimmune encephalomyelitis (EAE) is a well-known animal model of MS that is used to study the underlying mechanism and offers a theoretical basis for developing a novel therapy for MS. Good therapeutic effects have been observed after the administration of natural compounds and their derivatives as treatments for EAE. However, there has been a severe lag in the research and development of drug mechanisms related to MS. This review examines natural products that have the potential to effectively treat MS. The relevant data were consulted in order to elucidate the regulated mechanisms acting upon EAE by the flavonoids, glycosides, and triterpenoids derived from natural products. In addition, novel technologies such as network pharmacology, molecular docking, and high-throughput screening have been gradually applied in natural product development. The information provided herein can help improve targeting and timeliness for determining the specific mechanisms involved in natural medicine treatment and lay a foundation for further study.

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“…It has been used for rewarding psoriasis for quite a long time. This phytochemical details number of various pharmacological movements like antiviral, photograph defensive exercises against intense and constant photograph harm related with oxidative pressure decrease instigated by UVB (Li et al, 2020;Hung et al, 2018). As of late, utilizing the touch excessive touchiness model and mouse-tail psoriasis actuated by 2,4dinitrofluorobenzene, assessed its mitigating action and keratinocyte separation in vivo, exhibiting that the topical use of baicalin cream assuages incendiary response and advances keratization normally.…”

Section: Baicalinmentioning

confidence: 99%

A review on the important phytochemicals and their role in psoriasis

Pandey

Shukla

Dubey

et al. 2021

JANS

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Psoriasis may emerge at any stage of life irrespective of age, sex or geographic location. It is identified as a chronic immune-linked inflammatory skin disease that affects all human races. Psoriasis is often more Caucasian than non-Caucasian groups of human races and in geographic areas, like higher latitudes and Western countries. Therefore, attention should be paid to both genetic and environmental causes of psoriasis. Natural products have significantly contributed and encouraged the advances in skin disease treatment like psoriasis. The maximum number of phytochemicals is now being used worldwide, including various plants, herbs, and formulations. In addition, some phytochemicals like psoralen, aloe-emodin, curcumin etc. have also been isolated in pure form and have also shown their efficacy in the management of psoriasis. The presence of such phytochemicals confirms the effectiveness of few herbal therapies. This paper reviews some of the promising phytochemicals and their potential molecular target sites and mechanism of action, which may aid in designing and producing more precise and selective antipsoriatic agents. Exploring and recognizing phytochemicals as to how they function will facilitate more site-specific delivery methods for psoriasis care.

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Anti-inflammatory and immunomodulatory effects of baicalin in cerebrovascular and neurological disorders

Cited by 37 publications

References 90 publications

Baicalein and Baicalin Inhibit SARS-CoV-2 RNA-Dependent-RNA Polymerase

Baicalein and Baicalin Inhibit SARS-CoV-2 RNA-Dependent-RNA Polymerase

Role of Plant-Derived Natural Compounds in Experimental Autoimmune Encephalomyelitis: A Review of the Treatment Potential and Development Strategy

A review on the important phytochemicals and their role in psoriasis

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