Anti-inflammatory and Cytotoxic Effect of Arrow Root Mediated Selenium Nanoparticles

Francis, Twinkle; Rajeshkumar, S.; Roy, Anita; Lakshmi, T

doi:10.5530/pj.2020.12.188

Cited by 14 publications

(10 citation statements)

References 9 publications

(12 reference statements)

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“…The anti-inflammatory activity of the plant extracts can be due to the synergistic effect of proinflammatory enzyme inhibitors, free radical scavenging activities (16). The results of the present work suggest that the anti-inflammatory activities of these extracts could be explained, at least in part, by their antioxidant properties (17). Most biological proteins lose their biological function when denatured.…”

Section: Discussionmentioning

confidence: 62%

In-vitro antioxidant, anti-inflammatory and cytotoxic activity of Cucumis melo L. of ethanolic extract

Malathi¹,

Vadivelu²

2021

Biomedicine

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Introduction and Aim: Cucumis melo L. commonly known as wild melon (in English) belongs to the family Cucurbitaceae and well distributed in rural areas. Cucumis melo L. is a annual climbing or perennial herb, distributed almost throughout India and neighbouring countries. Nowadays food wastes are a major concern. On the other hand, the demand for natural valuable compounds to human health is increasing. These by-products contain phytochemical compounds with great nutritional and functional potentials. The fruits of this plant possess the abortifacient property and have antitussive, antioxidant, digestive, cytotoxic and anti-inflammatory properties. Materials and Methods: The ethanolic extract was used to determine the antioxidant scavenging activity using DPPH method, protein denaturation for anti inflammatory studies, as well as in vitro cytotoxic activity by brine shrimp lethal assay (BSLA). Results: The results obtained indicated highest antioxidant activity as compared to DPPH methods. The protein denaturation test showed the ethanolic extracts of Cucumis melo L. had effective anti-inflammatory activity. Extracts of Cucumis melo L. also registered potential cytotoxic activities by BSLA. This study provides the basis for further investigation of Cucumis melo L. for potential identification of novel bioactive compounds with therapeutic properties. Conclusion: The presence of phytoconstituents such as flavonoids, terpenoids, alkaloids, may indeed assist to the antioxidant activity of fruit extract. That this next thing that must be done will be to conduct in vivo experiments and discern the histopathological mechanism.

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Section: Discussionmentioning

confidence: 62%

In-vitro antioxidant, anti-inflammatory and cytotoxic activity of Cucumis melo L. of ethanolic extract

Malathi¹,

Vadivelu²

2021

Biomedicine

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“…Previous research works have reported on the various activities exhibited by the nanoparticles synthesised from natural sources such as cytotoxic, antimicrobial activity [47][48][49][50][51]. The antifungal effect of copper nanoparticles isolated from white fish (Rutilus frisii kutum) eggs were tested against the fungus Saprolegnia sp.…”

Section: Discussionmentioning

confidence: 99%

Biosynthesis of Copper Nanoparticles using Mucuna Pruriens and its Antioxidant and Antidiabetic Activity

Ali

Geetha

Rajeshkumar

2021

JPRI

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Introduction: The field of Nanotechnology has gained importance since last century. Nanoparticles can be used in medicine due to its increased interaction with microbes and has less side effects than drugs. Antioxidant compounds scavenge free radicals and inhibit the oxidative mechanisms that lead to degenerative diseases. There is a growing number of diabetes patients all over the world. Wide varieties of synthetic drugs are being used for the treatment of Type 2 diabetes mellitus, most of them possess side effects in the long run such as hepatotoxicity, abdominal pain, flatulence and diarrhea. Therefore, there is a need for a search of an alternate antidiabetic agent Aim: The aim of the study is to synthesize Copper nanoparticles from Mucuna pruriens and to evaluate its antioxidant and antidiabetic activity. Materials and methods: Plant extract of Mucuna pruriens was prepared and filtered by Whatman No 1 filter paper. Copper sulphate was added to the plant extract and kept in a magnetic stirrer for nanoparticle synthesis. The synthesized nanoparticle was preliminarily analysed using UV visible spectroscopy. Finally the left over solution was taken to calculate antioxidant activity and antidiabetic activity. Results: Antioxidant activity was calculated by DPPH method and the percentage of inhibition of copper nanoparticles synthesised from Mucuna pruriens was 58.5% for 10µL, 59.6% for 20µL, 67.5% for 30µL, 71.4% for 40µL and 72.3% for 50µL. Antidiabetic activity was calculated by alpha-amylase inhibitory assay and the percentage of inhibition of copper nanoparticles synthesised from Mucuna pruriens was 66% for 10µL, 69% for 20µL, 73% for 30µL, 79% for 40µL and 80% for 50µL. Conclusion: We can conclude that copper nanoparticles synthesised from Mucuna pruriens are a potent antioxidant and antidiabetic agent. Since it shows a good activity in free radical scavenging, copper nanoparticles can be used in a clinical therapeutic application and also in the management of type 2 diabetes mellitus.

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“…Phytochemicals studies indicated the presence of many phenolic glycosides like symploca-side, triterpenoids like betulinic acid, acetyl oleanolic acid and oleanolic acid and flavonoids like Quertin,anthrasinins like 3-mono glucofuranoside of 7-O methyl leucopelargonidin glycosides, symposides, tannins like allergic acid, alkaloids like loturine, loturidine and colloturine [11][12][13]. Inflammation is the body's first response to infection or injury and is critical for both innate and adaptive immunity [14,15]. It can be considered as part of the complex biological response of vascular tissues to harmful stimuli such as pathogens, damaged cells, or irritants [16].…”

Section: Introductionmentioning

confidence: 99%

In vitro Evaluation of Anti-Inflammatory Activity of Symplocos racemosa Using Protein Denaturation Assay

Janani

Geetha

Rajeshkumar

2021

JPRI

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Introduction: Recently there is considerable awareness and interest in the field of herbal medicine due to its natural origin and lesser side effects compared to Allopathy. Selected herbal plants like Symplocos racemosa, commonly known as lodhra, are found mainly in plains and lower hills of Bengal. The word ‘Lodhra’ means ‘Propitious’. Symplocos racemosa is an important Indian traditional drug used in many Ayurvedic and herbal formulations for treatment of liver as well as uterine disorders and leucorrhea. Ethnobotanical Literature indicates use of Symplocos racemosa in treatment of eye disease, skin disease, ear disorders, liver and bowel complaints, tumours,uterine disorders, spongy and bleeding gums, asthma, fever, snakebite, gonorrhoea and arthritis. Aim: To analyse the anti-inflammatory activity of Symplocos racemosa using protein denaturation assay. Materials and Methods: 2 g of Lodhra bark powder is mixed with 100 ml distilled water & boiled for 20 min at 50°C. The extract is filtered using whatman filter paper & concentrated to 10 ml.1 ml each of Bovine serum albumin is added to various fixations of plant extract (10μL - 50 μL) and the anti - inflammatory activity was evaluated by analysing the percentage inhibition. Results: From this study, it is evident that Lodhra has significant anti-inflammatory activity. At 50μℓ concentration, the plant extract shower higher anti- inflammatory activity of 76%. Conclusion: Symplocos racemosa extract has proved to exhibit effective anti- inflammatory activity. Further studies have to be carried to analyse the other properties of this herb, which can be incorporated successfully in the pharmaceutical industry.

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Anti-inflammatory and Cytotoxic Effect of Arrow Root Mediated Selenium Nanoparticles

Cited by 14 publications

References 9 publications

<i>In-vitro</i> antioxidant, anti-inflammatory and cytotoxic activity of <i>Cucumis melo L. </i>of ethanolic extract

<i>In-vitro</i> antioxidant, anti-inflammatory and cytotoxic activity of <i>Cucumis melo L. </i>of ethanolic extract

Biosynthesis of Copper Nanoparticles using Mucuna Pruriens and its Antioxidant and Antidiabetic Activity

In vitro Evaluation of Anti-Inflammatory Activity of Symplocos racemosa Using Protein Denaturation Assay

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