Anti-inflammatory and cardioprotective effects of n-3 polyunsaturated fatty acids and plant sterols in hyperlipidemic individuals

Micallef, Michelle; Garg, Manohar L.

doi:10.1016/j.atherosclerosis.2008.09.020

Cited by 136 publications

(95 citation statements)

References 26 publications

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“…Although previous studies have shown that PUFAs have antiinflammatory actions (12,25), however, current study indicated that hsCRP levels, an indicator of inflammation, were similar between PUFAs group and control group.…”

Section: Discussioncontrasting

confidence: 38%

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N-3 polyunsaturated fatty acids administration does not reduce the recurrence rates of atrial fibrillation and inflammation after electrical cardioversion: a prospective randomized study

Özaydın¹,

Erdoğan²,

Tayyar³

et al. 2011

Anadolu Kardiyol Derg

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N-3 polyunsaturated fatty acids administration does not reduce the recurrence rates of atrial fibrillation and inflammation after electrical cardioversion: a prospective randomized study N-3 çoklu doymamış yağ asitlerinin kullanımı elektriksel kardiyoversiyon sonrası inflamasyon ve atriyal fibrilasyon nüks oranlarını azaltmaz: Prospektif randomize bir çalışma ÖZETAmaç: Bu prospektif randomize çalışmanın amacı, n-3 çoklu doymamış yağ asitlerinin elektriksel kardiyoversiyon sonrası atriyal fibrilasyon (AF) nüksü üzerine olan etkilerini araştırmaktır.Yöntemler: Gerekli hasta sayısı, sinüs ritmi idamesinin amiyodaron grubunda %20, yağ asidi grubunda %65 olacağı tahmin edilerek hesaplandı. Alfa değeri 0.05 ve güç %80 olacak şekilde anlamlı sonuç elde etmek için her bir grupta 22 hastanın gerekli olduğu bulundu. Toplam 47 hasta elektriksel kardiyoversiyon öncesi amiyodaron (n=24) ve amiyodaron+n-3 çoklu doymamış yağ asidi (n=23) gruplarına randomize edildiler. Sonlanım noktası 12 aylık takipte AF nüksü olarak belirlendi. N-3 çoklu doymamış yağ asitlerinin inflamasyon üzerine olan etkisi C-reaktif protein düzeylerinin ölçülmesi ile değerlendirildi. İstatistiksel analiz eşleştirilmemiş Student t-testi, Mann-Whitney U testi Ki-kare testi ile yapıldı. Atriyal fibrilasyon nüksü, potansiyel etkili faktörleri kontrol ederek Cox oransal regresyon modeli ile değerlendirildi. Bulgular: Amiyodaron grubundaki 9 hastada (%37.5) ve amiyodaron+n-3 çoklu doymamış yağ asidi grubundaki 9 hastada (%39.1) nüks gözlendi (p=1). Cox regresyon analizinde, nüks için risk faktörleri önceden elektriksel kardiyoversiyon yapılmış olması (izafi risk 10.33; %95 GA 1.74-61.10; ABSTRACTObjective: The purpose of the present prospective randomized study was to evaluate the effects of n-3 polyunsaturated fatty acids on recurrence rates of atrial fibrillation (AF) and inflammation after electrical cardioversion. Methods: Calculation of the number of patients needed was based on the assumption of 20% and 65% chance of maintaining sinus rhythm with amiodarone and with polyunsaturated fatty acids, respectively. To observe a significant difference with an alpha level of 0.05 and a power of 0.80 it was necessary to include 22 patients in each group. A total of 47 patients were randomized to amiodarone (n=24) and amiodarone plus n-3 polyunsaturated fatty acids (n=23) groups before scheduled electrical cardioversion. The end-point was the recurrence of AF during 12-month follow-up. Effect of n-3 polyunsaturated fatty acids on inflammation was evaluated with high sensitivity C-reactive protein level measurements. Statistical analysis was performed using unpaired Student' t, Mann Whitney U and Chi-square tests. We analyzed the recurrence of AF using the Cox proportional hazards regression model to control for potentially confounding factors. Results: Nine patients in the amiodarone group (37.5%), and 9 patients in the amiodarone plus n-3 polyunsaturated fatty acids group (39.1%) had recurrence of AF during follow-up (p=1). With the Cox proportional model, risk f...

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Section: Discussioncontrasting

confidence: 38%

“…Statins, which have anti-inflammatory actions, have been shown to be effective in preventing AF in different patient populations (4)(5)(6)(7)(8)(9), including recurrence of AF after electrical cardioversion (EC) (10,11). N-3 polyunsaturated fatty acids (PUFAs) also have anti-inflammatory actions (12).…”

Section: Introductionmentioning

confidence: 99%

N-3 polyunsaturated fatty acids administration does not reduce the recurrence rates of atrial fibrillation and inflammation after electrical cardioversion: a prospective randomized study

Özaydın¹,

Erdoğan²,

Tayyar³

et al. 2011

Anadolu Kardiyol Derg

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“…Ensaios clínicos demonstram os efeitos benéficos do ω3 em pacientes com doença cardiovascular, sendo que os mecanismos envolvidos estão relacionados ao seu papel anti-inflamatório 12 , ao efeito na redução plasmática dos triacilglicerois 13 , à redução da frequência cardíaca de repouso 14 , da pressão arterial 11 e da arritmia 15 e à melhora da capacidade funcional do miocárdio 16 . Recentemente, Din et al 17 demonstraram que o ω3 melhorou a fibrinólise e a função endotelial em indivíduos tabagistas, considerado um grupo de alto risco para eventos cardiovasculares.…”

Section: N T R O D U ç ã Ounclassified

Impacto da suplementação com ácidos graxos ômega-3 nas subfrações da lipoproteína de alta densidade de indivíduos tabagistas

Pappiani

Damasceno

2016

Rev. Nutr.

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ObjetivoAvaliar o efeito da suplementação com ômega-3 nas subfrações das lipoproteínas de alta densidade em indivíduos tabagistas. MétodosEnsaio clínico, randomizado, duplo-cego. Foi selecionada uma amostra com 33 tabagistas, de ambos os sexos, com idade entre 30 e 60 anos, suplementados com ômega-3 (n=17) ou placebo (ácidos graxos ômega-6, n=16) por dois meses. As subfrações das lipoproteínas de alta densidade foram analisadas pelo sistema Lipoprint. Os testes estatísticos foram realizados com o auxílio do programa Statistical Package for the Social Sciences, versão 20.0. ResultadosA média de idade foi 49 anos, com predominância da raça branca. Após a intervenção, o grupo ômega-3 modificou positivamente o perfil lipídico e as subfrações das lipoproteínas de alta densidade dos tabagistas. Nos modelos de regressão linear testados, o percentual de ácido docosahexaenoico plasmático apresentou associações negativas com o percentual das lipoproteínas de alta densidade-pequena. ConclusãoA suplementação com ômega-3 está associada a uma alteração favorável na distribuição das subfrações das lipoproteínas de alta densidade, aumentando as lipoproteínas de alta densidade-grande e diminuindo as lipoproteínas de alta densidade-pequena. Isso reforça a importância do ômega-3 na saúde cardiovascular de indivíduos tabagistas. Palavras

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“…125 In addition, the combination of fish oil and phytosterol significantly reduced serum markers of inflammation. 126 Using a different approach, Jones and coworkers 127,128 used phytosterols that were esterified to fatty acids derived from fish oil (high in 22:6n−3 and 20:5n−3) vs sunflower oil (high in 18:2n−6) or olive oil (high in 18:1n−9). Their results indicated that phytosterols esterified with fish oil fatty acids did not alter LDL cholesterol levels compared with the other phytosterol esters, but fasting and postprandial triglycerides levels were significantly decreased in the fish oil phytosterol treatment.…”

Section: Omega-3 Fatty Acidsmentioning

confidence: 99%

Cholesterol-lowering phytosterols: factors affecting their use and efficacy

Carr¹

2010

NDS

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Phytosterols are essential components of plant cells and therefore naturally present in the human diet. When used therapeutically, phytosterols can significantly lower serum cholesterol concentrations. Meta-analyses of clinical trials indicate about 10% reduction of low-density lipoprotein cholesterol when phytosterols are consumed at the recommended dose of 2 g/d. Thus, phytosterols can be an important part of an overall dietary strategy to manage cholesterol levels, particularly for patients who cannot tolerate cholesterol-lowering drugs. Although other health benefits have been attributed to phytosterols, including anti-inflammatory, anticancer, and immune regulatory effects, this review will focus on the therapeutic use of phytosterols related to serum cholesterol, their mechanisms of action, and the various types of phytosterols available to consumers.

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Anti-inflammatory and cardioprotective effects of n-3 polyunsaturated fatty acids and plant sterols in hyperlipidemic individuals

Cited by 136 publications

References 26 publications

N-3 polyunsaturated fatty acids administration does not reduce the recurrence rates of atrial fibrillation and inflammation after electrical cardioversion: a prospective randomized study

N-3 polyunsaturated fatty acids administration does not reduce the recurrence rates of atrial fibrillation and inflammation after electrical cardioversion: a prospective randomized study

Impacto da suplementação com ácidos graxos ômega-3 nas subfrações da lipoproteína de alta densidade de indivíduos tabagistas

Cholesterol-lowering phytosterols: factors affecting their use and efficacy

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