Anti-inflammatory and Antinociceptive Effects of the Aqueous Extract of the Bark of Chrysobalanus icaco Linnaeus

Oliveira, Tatiane Bezerra de; Júnior, Carlson Helder Reis de Carvalho; Mota, Fernanda Virgínia Barreto; Araújo, Larissa Cardoso Corrêa de; Maia, Maria Bernadete Sousa; Randau, Karina Perrelli; Nascimento, Silène Carneiro do; Silva, Teresinha Gonçalves da

doi:10.9734/bjpr/2014/8742

Cited by 9 publications

(7 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These results do not rule out the possible anti-inflammatory effect of the lowest dose shown in screening tests such as abdominal writhing and formalin, however, no significant effect on mechanical hyperalgesia test can be explained by the high specificity of the test, since the paw withdrawal threshold is measured. These results corroborate previous findings of Oliveira et al (2014), which demonstrated analgesic and anti-inflammatory profiles of aqueous extract of the bark of C. icaco, however, this study suggested that these effects do not seem to be related to the levels of cytokines, such as TNF-a or IL-6.…”

Section: Resultssupporting

confidence: 92%

“…Recently, Oliveira et al (2014) demonstrated that the aqueous extract of the bark of C. icaco, at the same doses used in this study, also showed a potent anti-inflammatory action evidenced by the abdominal writhing test and the formalin test. Furthermore, the aqueous extract was able to reduce the concentration of nitric oxide in the inflammatory exudate.…”

Section: Resultssupporting

confidence: 56%

See 1 more Smart Citation

Phytochemical screening and analgesic profile of the lyophilized aqueous extract obtained from Chrysobalanus icaco leaves in experimental protocols

Araújo-Filho

Dias

Quintans‐Júnior

et al. 2016

Pharmaceutical Biology

View full text Add to dashboard Cite

Context: Chrysobalanus icaco L. (Chrysobalanaceae) has been used for the treatment of abdominal pain and cramps. Objective: Assess the chemical and pharmacological profile of the lyophilized aqueous extract from C. icaco leaves (AEC). Materials and methods: Chromatographic methods were used to assess compounds from AEC. Mice were treated with vehicle (control group) or AEC (100, 200 or 400 mg/kg, p.o.) (group with 7-8 mice) and the analgesic profile was assessed employing the acetic acid-induced writhing, formalin, hot plate tests and hyperalgesia induced by carrageenan (CG) or tumour necrosis factor-alpha. The animal motor performance was assessed using rota-rod and grip strength tests. Results:The chromatographic profile of AEC demonstrated the presence of terpenoid compounds. The acute pretreatment with AEC, at all doses, produced a significant (p < 0.01) inhibition of painful bahaviour (11.4 ± 3.6; 10.3 ± 2.8; 11.3 ± 2.2) when compared to the control group (24.7 ± 4.7) in acetic acid-induced writhing test. In the formalin test, AEC were effective in the second phase (p < 0.01) (57.2 ± 10.3; 56.3 ± 9.2; 54.7 ± 8.9) when compared to control group (121.9 ± 18.5). No response was observed in the hot plate test. The higher dose of AEC produced a significant (p < 0.01 or p < 0.05) inhibitory effect on the mechanical hyperalgesia test. AEC did not affect the motor performance of the mice. Discussion: The terpenoids from AEC are known for its analgesic and anti-inflammatory properties. So, these results corroborate the experiments using the AEC in inflammatory pain protocols. Conclusion: Our results suggest that AEC act against inflammatory pain. ARTICLE HISTORY

show abstract

Section: Resultssupporting

confidence: 92%

Section: Resultssupporting

confidence: 56%

Phytochemical screening and analgesic profile of the lyophilized aqueous extract obtained from Chrysobalanus icaco leaves in experimental protocols

Araújo-Filho

Dias

Quintans‐Júnior

et al. 2016

Pharmaceutical Biology

View full text Add to dashboard Cite

show abstract

“…The antidiabetic effect of C. icaco extracts has been investigated , as well as its anti‐inflammatory and antinociceptive , antileishmanial , antioxidant , genotoxic , antimicrobial , anti‐HIV , antiangiogenic , anti‐cancer and anti‐multidrug resistance properties and for preventing weight gain . Phytochemical studies have also reported the presence of flavonoids and terpenoids, which are pharmacologically important chemical groups .…”

Section: Introductionmentioning

confidence: 99%

“…flavonoids and terpenoids, which are pharmacologically important chemical groups [4,5,10,12,14,15,18,19].…”

mentioning

confidence: 99%

Chemotaxonomic study ofChrysobalanus icacoLinnaeus (Chrysobalanaceae) using ultra-high performance liquid chromatography coupled with diode array detection fingerprint in combination with multivariate analysis

et al. 2017

View full text Add to dashboard Cite

We investigated a strategy for the chemotaxonomy study of Chrysobalanus icaco Linnaeus (Chrysobalanaceae) based on ultra-high performance liquid chromatography coupled with diode array detection fingerprint in combination with multivariate analysis. Two models using principal component analysis and partial least squares discriminant analysis were developed, and the samples could be successfully classified into two classes: Class 1 (red morphotype) and Class 2 (white and black morphotypes). Furthermore, ultra-high performance liquid chromatography coupled with diode array and electrospray ionization tandem mass spectrometry was used to identify the main compounds responsible for class separation. The partial least squares discriminant analysis model accurately classified the C. icaco samples using an external validation subset with prediction ability of 100% and revealed the existence of two chemotypes. The most important finding obtained in this study is that the three morphotypes distinguished by the mature fruit color (white, red, and black) are not all phytoequivalent to each other.

show abstract

“…Tests in rodents have reported that the aqueous extract of the bark and leaves of C. icaco have analgesic properties [ 13 , 14 ]. Other pharmacological studies have also been reported, for example, on the anti-inflammatory activity of the aqueous extract of its bark [ 13 ], the antimicrobial activity of the methanolic leaf extract, and the hypoglycemic activity of the aqueous extract of its leaves [ 15 , 16 ]. Additionally, the aqueous extract of C. icaco leaves can prevent weight gain and liver fat accumulation in hypercaloric diet-induced obese mice [ 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of the Aqueous Extract of Chrysobalanus icaco Leaves on Maternal Reproductive Outcomes and Fetal Development in Wistar Rats

Rodrigues,

Oliveira,

Lima

et al. 2023

CIMB

View full text Add to dashboard Cite

Toxicological studies on medicinal plants are essential to ensure their safety and effectiveness in treating various diseases. Despite the species Chrysobalanus icaco L. being popularly used in the treatment of several diseases due to the pharmacological properties of its bioactive compounds, there are few studies in the literature regarding its toxicity regarding reproduction. Therefore, the purpose of this study was to assess the potential embryotoxic and teratogenic effects of the aqueous extract of C. icaco leaves (AECi) on Wistar rats. Animals were given AECi at doses of 100, 200, and 400 mg/kg during the pre-implantation and organogenesis periods. Data were analyzed using ANOVA followed by Tukey’s test and Kruskal–Wallis. Pregnant rats treated during the pre-implantation period showed no signs of reproductive toxicity. Rats that received AECi at 100, 200, and 400 mg/kg during organogenesis did not exhibit any signs of maternal systemic toxicity or significant differences in gestational and embryotoxic parameters. Some skeletal changes were observed in the treated groups. Therefore, it can be suggested that AECi at doses of 100, 200, and 400 mg/kg is safe for treated animals and does not induce reproductive toxicity under the experimental conditions applied, but it also caused low systemic toxicity.

show abstract

Anti-inflammatory and Antinociceptive Effects of the Aqueous Extract of the Bark of Chrysobalanus icaco Linnaeus

Cited by 9 publications

References 40 publications

Phytochemical screening and analgesic profile of the lyophilized aqueous extract obtained from Chrysobalanus icaco leaves in experimental protocols

Phytochemical screening and analgesic profile of the lyophilized aqueous extract obtained from Chrysobalanus icaco leaves in experimental protocols

Chemotaxonomic study ofChrysobalanus icacoLinnaeus (Chrysobalanaceae) using ultra-high performance liquid chromatography coupled with diode array detection fingerprint in combination with multivariate analysis

Effect of the Aqueous Extract of Chrysobalanus icaco Leaves on Maternal Reproductive Outcomes and Fetal Development in Wistar Rats

Contact Info

Product

Resources

About