Anti-inflammatory and antinociceptive activities of Daniellia oliveri (Fabaceace) stem bark extract

A review of indigenous knowledge and ethnopharmacological significance of African Copaiba Balsam Tree, Daniellia oliveri (Fabaceae)

“…Daniellia oliveri has been established to possess numerous pharmacological, biological and toxicity effects not limited to analgesic [ 31 , 54 ] antinociceptive, antioxidant [ 36 , 55 ], antidiabetic [ 8 , 35 , 51 , 56 ], antidiarrhoeal [ 30 , 43 ], anthelminthic [ 57 ], anti-inflammatory [ 31 , 44 , 54 , 55 ], antimelanogenesis [ 52 ], antimicrobial [ 7 , 24 , 45 , 46 , [58] , [59] , [60] , [61] ], antioxidant [ 41 , 62 , 63 ], antiplasmodial [ 64 ], antisickling [ 65 ], antispasmodic [ 66 ], cytotoxic [ 28 , 67 ], cardiotoxic [ 68 ], neuroprotective [ 14 ] and safety profiles [ 31 , 34 , 35 , 55 , 56 ] as discussed below. Table 3 summarises the in vitro and in vivo pharmacological activities of D. oliveri.…”

“… Produced a lower pain threshold at concentrations from 500 mg/kg and above better than diclofenac indicating its potential antinociceptive effect. Extract inhibited nociception in the animals Ghana Nigeria [ 36 ] [ 55 ] 3 Antioxidant and hepatoxic Leaves, stem bark and root bark Seed (oil) Leaves and stem bark Stem bark Cold aqueous-methanol (50%) Hexane Ethanol Ethanol In vitro (DPPH, ABTS, phosphomolybdenum (PPM)) In vitro (DPPH) In vitro (Hydroxyl radical, metal chelating, reducing power, and lipid peroxidation In vitro (DPPH, FRAP, and PPM) In vivo (CCl 4 -induced hepatotoxic rats) 100 μM 0.03, 0.06, 0.125, 0.25 and 0.50 mg/ml 20, 40, 60, 80 and 100 μg/mL 156.25–5000 μg/mL 100, 200 and 300 mg/kg b.w. The leaves extract reported to have best activity inhibiting DPPH radical (93.3%).…”

“…Expectedly, 400 mg/kg b.w. being the highest concentrations was reported to show superior activities (77.81% and 85.97% respectively) comparable to AAS (87.3%) Doses at 100 and 200 mg/kg significantly inhibited (73.68 and 75.79%) oedema and diminishes the volume of the exudate, myeloperoxidase production and protein concentration in carrageenan model Burkina Faso Nigeria [ 31 ] [ 55 ] 8 Antimicrobial Leaves, bark, root Aqueous, ethanol In vitro (broth dilution method) 100 mg/ml Ethanol extract revealed better activity as depicted by the higher zone of inhibition. Root extracts depicted better inhibition of the tested strains indicative of antibacterial effect.…”

“…indicating the safety potential of the extract. No signs of toxicity and death were reported following 2 weeks of observing the animals, hence, maintained that the LD 50 is greater than 5000 mg/kg b.w., thus, not toxic No sign of toxicity or mortality, hence safe for oral consumption at concentration below 2000 mg/kg Nigeria Nigeria Nigeria Cote D′ Ivoire Burkina Faso Nigeria [ 34 ] [ 56 ] [ 35 ] [ 44 ] [ 31 ] [ 55 ] NS: not stated; DPPH: 1,1-diphenyl-2-picryl hydrazyl radical; ABTS: 2,2 _ -azino- bis (3-ethylbenzothiazoline-6-sulfonic; BHT: butylated hydroxyl toluene; BHA: butylated hydroxyl anisole; FBG: fasting blood glucose; EHA: egg hatch assay; EEA: embryonated egg assay; ASA: acetylsalicyclic acid; OECD: organization for economic co-operation and development; MIC: minimum inhibitory concentration; ZID: zone of inhibition diameter; DW: dry weight; VCEAC: vitamin C equivalent antioxidant capacity; FRAP: ferric reducing antioxidant power; PCV: packed cell volume; MTT: 3-[4,5-dimethylthiazole-2-yl]-2,5-diphenyltetrazolium bromide; DMSO: dimethyl sulfoxide; DCM: dichloromethane; IC 50 : Half-maximal inhibitory concentration; ED 50 : (Median) Effective dose; EC 50 : Half-maximal Effective concentration; LD 50 : Median Lethal dose; MHC: mean haemoglobin concentration. …”

“… Hexadecanoic acid, 3,12-Octadecadienal, 8-methyl 6 nonenamide and 5,9-dimethyl cyclodecanol 6-linalool, Aromadendrene, α- caryophyllen, Germacrene D, Naphtalene, Caryophyllene oxide, 1,5,5,5,8-tetramethyl-12-oxabicyclo [ 9 , 10 ] dodeca-3,7-diene, T- murolol, Tricyclo [5.2.2.0(1,6)] undecane-3-ol, Hexadecanoic acid, 3,7,11,15- tetramethyl-2-hexadecen-1-ol, Cis, cis, cis, 7-10-13-hexadecatrienal, 6-chamigrene, (7a-isopropenyl-4,5-dimethyloctahydroinden-4-y) methanol, Aromadendrin oxide, Cadina-1(10),4-diene/ δ -Cadinene, Humulene-1,2-epoxide/Humulene epoxide 2 and 9,12-Octadecadienoic acid. GC-MS Togo [ 20 ] 9 Leaves Stem bark n-Hexadecanoic acid, 15-Hydroxypentadecanoic acid, Tetradecanoic acid, Glycidyl palmitate, Octadecanoic acid, 2-hydroxy-1, 3-propanediyl ester, cis-Vaccenic acid, Oleic acid, Cyclopentadecanone, 2-hydroxy, 9-Octadecenal, (Z), trans -13-Octadecenoic acid, 15-Hydroxypentadecanoic acid, Lauric anhydride, Lauric acid, 3, 4-dichlorophenyl ester, Carazolol, Dodecanoic acid, 1-(hydroxymethyl)-1, 2- ethanediyl ester GC-MS Nigeria [ 120 ] 10 Stem bark Ethanol Caffeic acid, p -coumaric acid, ferulic acid, rutin, apigenin-7-glucoside, quercetin and kaempferol HPLC Nigeria [ 55 ] GC: gas chromatography; GC-MS: gas chromatography-mass spectrometry; HPLC: high-pressure liquid chromatography; RP-HPLC: reverse-phase high-pressure liquid chromatography; DCM: dichloromethane; NS: not stated. …”