Anti-Inflammatory and Antimicrobial Activities of Compounds Isolated from Distichochlamys benenica

Abstract

Distichochlamys benenica is a native black ginger that grows in Vietnam. In point of fact, there is limitation of available information in the literature making mention of the chemical constituents and bioactive properties of this plant. This study is aimed at isolating trans-o-coumaric acid (1), trans-cinnamic acid (2), and borneol (3) from the rhizomes of D. benenica Q.B.Nguyen & Škorničk and evaluate the anti-inflammatory and antimicrobial activities of 1-3 using the carrageenan paw edema model and the dilution broth method, respectively. This revealed that 1 was as effective as diclofenac in reducing the intensity of the edema development. The in silico research showed that the activity of 1 might be derived from inhibiting COX-2 by generating h-bonds at the positions of Arg 120, Tyr 355, and Arg 513 residues. The antimicrobial activities against Gram-positive strains (Staphylococcus aureus and Bacillus subtilis) were comparable, with the minimum inhibitory concentrations ranging from 1.52 to 3.37 mM. This is the first study of the bioactivity of compounds isolated from D. benenica Q.B.Nguyen & Škorničk. Our results suggest that 1 may be a nature-derived compound which demonstrates the anti-inflammatory properties and inhibit the proliferation of several Gram-positive bacteria.

Antioxidant activity and α-glucosidase inhibitability of Distichochlamys citrea M.F. Newman rhizome fractionated extracts: in vitro and in silico screenings

“…These phytochemicals are likely to contribute to various medicinal uses as well as nutritional supplementations of the herbs. Hithermost, only the plant family Distichochlamys benenica has been reported for the acetylcholinesterase inhibitory effect of its rhizome essential oil (Hoang et al 2020 ) and the anti-inflammatory and antibacterial activities of its isolated compounds (Pham et al 2021 ). Further than that, this work is the first time the biological effects of Distichochlamys citrea are reported in the literature.…”

Sulfated Polysaccharides Derived from Hypnea valentiae and Their Potential of Antioxidant, Antimicrobial, and Anticoagulant Activities with In Silico Docking

“…Carrageenan had been exploited with antimicrobial, antiviral, and anticancer activity. The current research observed a significant interaction of the carrageenan with multiple targets resulting majorly around −7 to −6 Kcal/mol binding score [ 28 , 77 ].…”

N-Aryl iminochromenes inhibit cyclooxygenase enzymesviaπ–π stacking interactions and present a novel class of anti-inflammatory drugs

“…The general conditions of Desmond were established according to the previous study. 36 The solvent model was set with a flexible simple point-charge water model with the OPLS3e force field. 50 nanoseconds (ns) and 50 picoseconds (ps) were set as the total simulation time and the trajectory recording interval, respectively.…”