Anti-Inflammatory and Anticancer Drugs from Nature

Abstract

Over the centuries, plant extracts have been used to treat various diseases. Until now, natural products have played an important role in anticancer therapy as there are more than 500 compounds from terrestrial and marine plants or microorganisms, which have antioxidant, antiproliferative, or antiangiogenic properties and are therefore able to reduce tumor growth. The recent discovery of new natural products has been accelerated by novel technologies (high throughput screening of natural products in plants, animals, marine organisms, and microorganisms). Vincristine, irinotecan, etoposide, and paclitaxel are examples of compounds derived from plants that are used in cancer treatment. Similarly, actinomycin D, mitomycin C, bleomycin, doxorubicin, and L-asparaginase are drugs derived from microorganisms. In this review, we describe the molecular mechanisms of natural compounds with anti-inflammatory and anticancer activities.

Flavonnoids with Antithrombotic Activities: a Review

“…Isobavachalcone (37) could inhibit the aggregation induced by arachidonic acid (AA) (IC50=0.5 μM). Neobavaisoflavone (38) could inhibit the aggregation induced by AA and platelet-activating factor (IC50=7.8 and 2.5 μM, respectively). Compared to the aspirin with 32.7 μM, neobavaisoflavone (38) with 7.8 μM exhibited significantly inhibitory potency on platelet aggregation.…”

“…[26][27][28][29][30][31][32][33][34][35] Natural products are divided into diverse chemical compounds isolated from varied biological sources such as plants, animals, marine organisms, microorganisms, minerals, and organic matters. [36][37][38][39] In recent years, the research on natural products becomes a hot issue in drug research. The drug discovery from natural products possesses several advantages such as timeliness, faster and better methods for bioassay screening, and compound isolation.…”

Efecto quimioprotector del extracto alcaloideo de Melocactus bellavistensis (CACTUS GLOBOSO) sobre el cáncer de colon inducido con 1,2-dimetilhidrazina en ratas

“…Las plantas tienen una larga historia en el tratamiento del cáncer, aunque muchas veces han sido observadas con cierto escepticismo por las características propias de la enfermedad (3,4) . De los productos de origen natural con actividad anticancerígena, los más conocidos son los alcaloides de la vinca (vinblastina y vincristina) aisladas de Catharanthus roseus (C. roseus), que fueron usadas en varias culturas para el tratamiento de la diabetes (4,5) . Es así que en nuestro país existen numerosas especies con propiedades medicinales que requieren ser estudiadas.…”

“…Es así que en nuestro país existen numerosas especies con propiedades medicinales que requieren ser estudiadas. Es ampliamente conocido que alcaloides de origen vegetal poseen actividad anticancerígena, como por ejemplo: los alcaloides de la vinca (5) , la campotecina, el placitaxol, la berberina y la capsaicina (6,7) . La familia Cactaceae comprende más de 1500 especies, pero solo recientemente unas pocas de ellas han sido ensayadas por sus atributos quimiopreventivos y anticancerígenos, como Opuntia ficus (8) .…”

Overcoming tumor cell chemoresistance using nanoparticles: lysosomes are beneficial for (stearoyl) gemcitabine-incorporated solid lipid nanoparticles

“…34,35 Natural products Natural products, molecules discovered and isolated from living organisms and possessing biological or pharmacological activity, are commonly utilized for cancer chemotherapy. 36,37 In addition, natural products can also be synthesized, with chemical property equivalent to their natural counterparts. Many anticancer drugs such as paclitaxel, vinblastine, etoposide, and hydroxycamptothecine are all natural products.…”