Anti-Inflammatory and Anti-Ulcer Activities of Carvacrol, a Monoterpene Present in the Essential Oil of Oregano

Silva, Francilene V.; Guimarães, Adriana Gibara; Silva, Elayne R S; Sousa-Neto, Benedito P; Machado, Flávia Danniele Frota; Quintans‐Júnior, Lucindo José; Arcanjo, Daniel Dias Rufino; Oliveira, Francisco de Assis; Oliveira, Rita C. M.

doi:10.1089/jmf.2012.0102

Cited by 101 publications

(67 citation statements)

References 44 publications

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“…Therefore, it is likely that ROS play a central role in perpetuating the (Turkez and Togar 2010;Fabian et al 2013). This is in accordance with the results obtained by Silva et al (2012), which demonstrated that the increasing dose of CAR was effective to protect against inflammation in gastric lesions. Additionally, CAR is able to control receptors that play an important role in inflammation (Hotta et al 2010).…”

Section: Discussionsupporting

confidence: 90%

The carvacrol ameliorates acute pancreatitis-induced liver injury via antioxidant response

et al. 2015

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Acute pancreatitis (AP) may cause significant persistent multi-organ dysfunction. Carvacrol (CAR) possesses a variety of biological and pharmacological properties. The aim of the present study was to analyze the hepatic protection of CAR on AP induced by cerulein and to explore the underlying mechanism using in vivo studies. The rats were randomized into groups to receive (1) no therapy; (2) 50 lg/kg cerulein at 1-h intervals by four intraperitoneal injection (i.p.); (3) 50, 100 and 200 mg/kg CAR by one i.p.; and (4) cerulein ? CAR after 2 h of cerulein injection. 12 h later, serum was provided to assess the blood AST, ALT and LDH values. Also, liver tissues were obtained for histological and biochemical measurements. Liver oxidative stress markers were evaluated by changes in the amount of lipid peroxides measured as MDA and changes in tissue antioxidant enzyme levels, SOD, CAT and GSHPx. Histopathological examination was performed using scoring systems. Oxidative damage to DNA was quantitated in studied tissues of experimental animals by measuring the increase in 8-hydroxydeoxyguanosine (8-OHdG) formations. We found that the increasing doses of CAR decreased pancreatitisinduced MDA and 8-OH-dG levels. Moreover, the liver SOD, CAT and GSH-Px activities in the AP ? CAR group were higher than that of the rats in the AP group. In the treatment groups, AST, ALT and LDH were reduced. Besides, necrosis, coagulation and inflammation in the liver were alleviated (p \ 0.05). We suggest that CAR could be a safe and potent new drug candidate for treating AP through its antioxidative mechanism of action for the treatment of a wide range of disorders related to hepatic dysfunction.

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Section: Discussionsupporting

confidence: 90%

The carvacrol ameliorates acute pancreatitis-induced liver injury via antioxidant response

et al. 2015

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“…Furthermore, their bioactivity as antibacterial, antiviral, antioxidant and antidiabetic agents has previously been reported (18). Recent studies have demonstrated the anti-inflammatory properties of essential oils from several plants (19)(20)(21). In the present study, we demonstrated that the essential oil from C. obtusa has an anti-inflammatory effect on LPS-induced inflammation in rats.…”

Section: Discussionsupporting

confidence: 61%

Anti-inflammatory effects of essential oils from Chamaecyparis obtusa via the cyclooxygenase-2 pathway in rats

Kang

Yang

et al. 2013

Molecular Medicine Reports

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Abstract. Essential oils are concentrated hydrophobic liquids containing volatile aromatic compounds from plants. In the present study, the essential oil of Chamaecyparis obtusa (C. obtusa), which is commercially used in soap, toothpaste and cosmetics, was extracted. Essential oil extracted from C. obtusa contains several types of terpenes, which have been shown to have anti-oxidative and anti-inflammatory effects. In the present study, we examined the anti-inflammatory effects of C. obtusa essential oil in vivo and in vitro following the induction of inflammation by lipopolysaccharides (LPS) in rats. While LPS induced an inflammatory response through the production of prostaglandin E 2 (PGE 2 ) in the blood and peripheral blood mononuclear cells (PMNCs), these levels were reduced when essential oil was pre-administered. Additionally, the mechanism of action underlying the anti-inflammatory effects of C. obtusa essential oil was investigated by measuring the mRNA expression of inflammation-associated genes. LPS treatment significantly induced the expression of transforming growth factor α (TNFα) and cyclooxygenase-2 (COX-2) in rats, while C. obtusa essential oil inhibited this effect. Taken together, our results demonstrate that C. obtusa essential oil exerts anti-inflammatory effects by regulating the production of PGE 2 and TNFα gene expression through the COX-2 pathway. These findings suggest that C. obtusa essential oil may constitute a novel source of anti-inflammatory drugs.

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“…Overall, the anti-inflammatory effect of ether and dichloromethane fractions of Cryptostegia grandiflora is similar or higher to that observed for indomethacin, anti-inflammatory drug used as a reference [21, 22]. Therefore, these promissory fractions were selected to evaluate their effect on NO and PGE2 production by LPS-induced macrophages RAW 264.7 and their scavenging effect of DPPH, ABTS and NO radicals, in order to get further insights into the mechanisms related with the anti-inflammatory activity.…”

Section: Resultsmentioning

confidence: 69%

In vivo and in vitro anti-inflammatory activity of Cryptostegia grandiflora Roxb. ex R. Br. leaves

Castro¹,

Ocampo²,

Franco³

2014

biol res

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BackgroundDespite Cryptostegia grandiflora Roxb. ex R. Br. (Apocynaceae) leaves are widely used in folk Caribbean Colombian medicine for their anti-inflammatory effects, there are no studies that support this traditional use. Therefore, this work aimed to evaluate the effect of the total extract and primary fractions obtained from Cryptostegia grandiflora leaves, using in vivo and in vitro models of inflammation, and further get new insights on the mechanisms involved in this activity.ResultsEthanolic extract of Cryptostegia grandiflora leaves, and its corresponding ether and dichloromethane fractions, significantly reduced inflammation and myeloperoxidase activity (MPO) in ear tissue of mice treated with 12-O-tetradecanoyl-phorbol-13-acetate (TPA). Histological analysis revealed a reduction of edema and leukocyte infiltration. Complementarily, we demonstrated that extract and fractions reduced nitric oxide (NO•) and prostaglandin E2 (PGE2) production in LPS-stimulated RAW 264.7 macrophages, as well as scavenging activity on DPPH and ABTS radicals.ConclusionsOur results demonstrated for the first time the anti-inflammatory activity of Cryptostegia grandiflora leaves, supporting its traditional use. This activity was related to inhibition of MPO activity, and PGE2 and NO• production. These mechanisms and its antioxidant activity could contribute, at least in part, to the anti-inflammatory effect showed by this plant.

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Anti-Inflammatory and Anti-Ulcer Activities of Carvacrol, a Monoterpene Present in the Essential Oil of Oregano

Cited by 101 publications

References 44 publications

The carvacrol ameliorates acute pancreatitis-induced liver injury via antioxidant response

The carvacrol ameliorates acute pancreatitis-induced liver injury via antioxidant response

Anti-inflammatory effects of essential oils from Chamaecyparis obtusa via the cyclooxygenase-2 pathway in rats

In vivo and in vitro anti-inflammatory activity of Cryptostegia grandiflora Roxb. ex R. Br. leaves

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