Anti-inflammatory and Anti-oxidative Effects of <i>Alpiniae Oxyphyllae Fructus</i> Hot Aqueous Extract in Lipopolysaccharide (LPS)-stimulated Macrophages

Jo, Na Young; Lee, Pyeong Jae; Roh, Jeong Du

doi:10.13045/acupunct.2017085

The Acupuncture

2017

DOI: 10.13045/acupunct.2017085

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Anti-inflammatory and Anti-oxidative Effects of Alpiniae Oxyphyllae Fructus Hot Aqueous Extract in Lipopolysaccharide (LPS)-stimulated Macrophages

Na Young Jo

Pyeong Jae Lee

Jeong Du Roh

Abstract: [Abstract]

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Cited by 3 publications

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“…Recently, Dantas et al showed that nootkatone inhibited acute and chronic inflammation in mice model (Dantas et al, 2020). Recently, antiinflammatory effect of A. oxyphylla aqueous extract in RAW264.7 cells has been reported (Jo et al, 2017). In our previous study, A. oxyphylla ethanol extract (AOE) showed inhibitory effect on cartilage degradation in a monosodium iodoacetate (MIA)-induced OA animal model and also showed anti-inflammatory and analgesic activities in animal models, and inhibitory effect on proteoglycan degradation from interleukin-1α (IL-1α)-treated rabbit articular cartilage (Lee et al, 2019;Yu et al, 2020).…”

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Chondroprotective effect of Alpinia oxyphylla extract in experimentally induced cartilage degradation in rabbit articular cartilage explants

Jeon¹,

Yu²,

Lee³

et al. 2021

J Food Biochem

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Alpinia oxyphylla is a widely used medicinal herb for diarrhea, gastralgia, tumors, hypertention, and cerebrovascular disorders. Here, we evaluated the chondroprotective effect of A. oxyphylla dried fruit ethanol extract (AOE) against cartilage degradation in rabbit articular cartilage explants. Treatment of interleukin-1α (IL-1α) and plasminogen increased degraded collagen release in culture supernatants, but pretreatment of AOE (50, 100, 200 µg/ml) inhibited the collagen release in dose-dependent manner. To examine the mechanism of action of AOE on chondroprotection, the level of matrix metalloproteinases-3 (MMP-3), matrix metalloproteinases-13 (MMP-13), tissue inhibitor of metalloprotease-1 (TIMP-1), and inflammatory mediators like prostaglandin E 2 (PGE 2 ) and nitric oxide (NO) was evaluated. AOE inhibited upregulation of MMP-3 and MMP-13 and downregulation of TIMP-1 and also reduced increase of PGE 2 and NO level induced by exposure of IL-1α and plasminogen. These results indicate that AOE show chondroprotective effect through inhibiting collagen degradation via regulating MMPs, TIMP-1, and inflammatory mediators. Practical applicationsOsteoarthritis (OA) is a one of the most common chronic disorders in elderly persons.Because the regenerative power of joint articular cartilage is very low, treatment of OA is difficult to expect complete recovery. Therefore, there is a need to develop a therapeutic agent that can safely and effectively inhibit the cartilage destruction.For the first time, we exhibited the inhibitory effect of AOE on collagen degradation through regulating MMPs and TIMP-1 in articular cartilage explants. These findings support AOE could be used as herbal therapeutic application for protecting articular cartilage to prevent OA.

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Chondroprotective effect of Alpinia oxyphylla extract in experimentally induced cartilage degradation in rabbit articular cartilage explants

Jeon¹,

Yu²,

Lee³

et al. 2021

J Food Biochem

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Dynamic Changes of Transcriptome and Metabolites During Ripening of Alpinia Oxyphylla Fruit (AOF)

Pan

Wang

et al. 2022

J. Plant Biol.

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Effect of Alpinia oxyphylla extract in vitro and in a monosodium iodoacetate-induced osteoarthritis rat model

Lee¹,

Son²,

Kim³

et al. 2019

Phytomedicine

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Anti-inflammatory and Anti-oxidative Effects of Alpiniae Oxyphyllae Fructus Hot Aqueous Extract in Lipopolysaccharide (LPS)-stimulated Macrophages

Abstract: [Abstract]

Cited by 3 publications

References 20 publications

Chondroprotective effect of Alpinia oxyphylla extract in experimentally induced cartilage degradation in rabbit articular cartilage explants

Chondroprotective effect of Alpinia oxyphylla extract in experimentally induced cartilage degradation in rabbit articular cartilage explants

Dynamic Changes of Transcriptome and Metabolites During Ripening of Alpinia Oxyphylla Fruit (AOF)

Effect of Alpinia oxyphylla extract in vitro and in a monosodium iodoacetate-induced osteoarthritis rat model

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