Anti-inflammatory, analgesic activity and acute toxicity of Sida cordifolia L. (Malva-branca)

Franzotti, Elaine Maria; Santos, Ccmp; Rodrigues, H.M.S.L; Mourão, Rosa Helena Veras; Andrade, Márcio Roberto de; Antoniolli, Ângelo Roberto

doi:10.1016/s0378-8741(00)00205-1

Cited by 276 publications

(179 citation statements)

References 4 publications

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“…Thus, the dose 200 mg/kg was ineffective as antiedematogenic. According to the results obtained from the infl ammation models used in the present study, S. cordifolia seems not to interfere with the lipooxygenase pathway but rather with the cyclooxygenase pathway (prostaglandin biosynthesis) (Franzotti et al, 2000).…”

Section: Anti-infl Ammatory Activity Of Crude Plant Extractssupporting

confidence: 58%

“…Therefore, that study results, provide a preliminary scientifi c foundation for the use of P. pubescens infusions in popular medicine for the treatment of rheumatoid arthritis. Franzotti et al (2000) studied Sida cordifolia L. (Malvaceae) which is popularly known in Brazil as "malva-branca" or "malva-branca-sedosa". The aqueous extract (AE) of S. cordifolia leaves was studied to assess the anti-infl ammatory properties using the carrageenin and arachidonic acid induced rat paw edema model.…”

Section: Anti-infl Ammatory Activity Of Crude Plant Extractsmentioning

confidence: 99%

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Review of the plants with anti-inflammatory activity studied in Brazil

Falcão¹,

Lima²,

Santos³

et al. 2005

Rev. bras. farmacogn.

119

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ABSTRACT:The infl ammatory reaction is a response of the organism against an injury and it involves the action of complex events and mediators through of the blood vessels. The present work is a literature survey of the extracts of plants with anti-infl ammatory activity studied in Brazil. The review refers to 75 plants with their families, parts used, type of extract used, bioassay models and their activity.

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Section: Anti-infl Ammatory Activity Of Crude Plant Extractssupporting

confidence: 58%

Section: Anti-infl Ammatory Activity Of Crude Plant Extractsmentioning

confidence: 99%

Review of the plants with anti-inflammatory activity studied in Brazil

Falcão¹,

Lima²,

Santos³

et al. 2005

Rev. bras. farmacogn.

119

View full text Add to dashboard Cite

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“…The abdominal injection of acetic acid in mice has been attributed to the release of arachidonic acid via the cyclooxygenase enzyme. Also, it has been suggested that the inhibition of prostaglandin synthesis by this pathway is remarkably efficient as an anti-nociceptive mechanism in visceral pain (Franzotti et al 2002). Since all tested doses of Z. montana leaf extract were able to inhibit the acetic acid-induced writhes, the peripheral analgesic activity exhibited by this extract may be related to the inhibition of prostaglandin production.…”

Section: Resultsmentioning

confidence: 91%

Anti-inflammatory and anti-nociceptive effects of Zeyheria montana (Bignoniaceae) ethanol extract

Guenka

Gomes

Melo

et al. 2008

Mem. Inst. Oswaldo Cruz

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“…Franzotte et al, (2000) reported low acute toxicity of AESC leaves in mice [21]. Rao and Mishra reported that the lethal dose 50% (LD 50 ) value for S. cordifolia was higher than 10 g/kg in rats [22].…”

Section: Discussionmentioning

confidence: 99%

Ameliorative Effect of Sida Cordifolia L. Against Scopolamine-Induced Cognitive Deficit Mice Model

Khurana

Sharma

Patil

et al. 2017

Asian J Pharm Clin Res

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Objective: In this study, ameliorative effect of aqueous extracts of Sida cordifolia and hydroethanolic extracts of S. cordifolia L. (AESC and EESC, respectively) was evaluated against scopolamine (Sco)-induced amnesia in mice. S. cordifolia L. is a well-know Ayurvedic plant which has been administered anciently for various nervous disorders including loss of memory. Female Swiss albino mice were used for Sco-induced amnesia model and acute toxicity study.Methods: Acute toxicity study was carried out to select safe and effective doses (50, 100 and 250 mg/kg; p.o.) of AESC and EESC for further pharmacological evaluation. The AESC and EESC at selected doses and donepezil (Dpl) (5 mg/kg; p.o.) were administered to different groups for consecutive 15 days. On 15 th day of treatment, Sco (0.4 mg/kg, intraperitoneally) was administered to different groups for induction of amnesia. Mice were subjected to transfer latency (TL) and step down latency (SDL) tests on the 16 th day to evaluate the effect of AESC and EESC on memory.Results: Sco treatment caused a significant increase in TL and decrease in SDL. The EESC significantly and dose dependently reversed the Sco-induced amnesia. The maximum effect was seen in EESC (100 mg/kg) treated group. This effect of EESC was comparable to the group treated with Dpl. The group treated with varying doses of AESC showed no significant effect on TL and SDL. Conclusion:These findings suggested the possible therapeutic potential of EESC (70%) for diseases related to memory dysfunctions like dementia in Alzheimer's disease.

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Anti-inflammatory, analgesic activity and acute toxicity of Sida cordifolia L. (Malva-branca)

Cited by 276 publications

References 4 publications

Review of the plants with anti-inflammatory activity studied in Brazil

Review of the plants with anti-inflammatory activity studied in Brazil

Anti-inflammatory and anti-nociceptive effects of Zeyheria montana (Bignoniaceae) ethanol extract

Ameliorative Effect of Sida Cordifolia L. Against Scopolamine-Induced Cognitive Deficit Mice Model

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