Anti-inflammatory alkaloids from the cold-seep-derived fungus Talaromyces helicus SCSIO41311

Cong, Mengjing; Zhang, Yi; Feng, Xinyue; Pang, Xiaoyan; Liu, Yonghong; Zhang, Xiaoyong; Yang, Zhiyou; Wang, Junfeng

doi:10.1007/s13205-022-03237-9

Cited by 7 publications

(5 citation statements)

References 25 publications

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“…For example, the compound expansol C (2) showed cytotoxic activity against human acute promyeloid leukemia cells (HL-60). 9 Compound 1-hydroxyboivinianin A (10) showed strong inhibition against V harveyi with MIC 19.4 μM. 12 Expansol F (1) exhibited antifouling activity against Bugula neritina with LC 50 of 6.8 μM.…”

Section: Resultsmentioning

confidence: 99%

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Research on Secondary Metabolites From the Soft Coral-Associated Fungus Aspergillus sydowii SCSIO41203 and Their Bioactivities

Chen,

Yang,

Liu

2023

Natural Product Communications

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Objective: As part of our ongoing search for bioactive secondary metabolites, the Beibu Gulf soft coral-derived fungus Aspergillus sydowii SCSIO41203 was investigated, which led to the isolation of 15 compounds. Methods: These compounds were purified by chromatographic methods, including normal phase silica gel column chromatography, octadecylsilyl column chromatography, Sephadex LH-20, and high-performance liquid chromatography. Their structures were elucidated by nuclear magnetic resonance, and mass spectrometry and compared their data with those related metabolites in the literature. Results: The structures of 1 to 15 were identified as expansol F (1), expansol C (2), expansol D (3), ( Z)-5-(hydroxymethyl)-2-(6′-methylhept-2′-en-2′-yl)phenol (4), ( E)-5-(hydroxymethyl)-2-(6′-methylhept-2′-en-2′-yl)phenol (5), sydonol (6), (-)-(7 R,10 S)-10-hydroxysydowic acid (7), (-)-(7 R,10 R)- iso-10-hydroxysydowic acid (8), sydowic acid (9), 1-hydroxyboivinianin A (10), (+)-sydonic acid (11), 3-hydroxydiorcinol (12), cordyol C (13), ( R)-mevalonolactone (14), and 4-methyl-5,6-dihydropyren-2-one (15). These isolated compounds were evaluated for antibacterial, cytotoxic, and enzyme-inhibitory activities. Among them, compounds 1 to 3 and 13 showed moderate acetylcholinesterase inhibitory activity, with IC50 values of 3.9, 33.8, 11.5, and 19.8 μM, respectively, with the positive control (tacrine) of 0.5 μM.

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Section: Resultsmentioning

confidence: 99%

“…These structures show antibacterial, antioxidant, and cytotoxic activities, which are valuable for further study. [6][7][8][9][10] In addition, acetylcholinesterase (AChE) is one of the key enzymes involved in Alzheimer's disease (AD). 11 The compounds inhibiting AChE are thought to have promising anti-AD activities worth further research.…”

Section: Introductionmentioning

confidence: 99%

Research on Secondary Metabolites From the Soft Coral-Associated Fungus Aspergillus sydowii SCSIO41203 and Their Bioactivities

Chen,

Yang,

Liu

2023

Natural Product Communications

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“…Fumigatin oxide was isolated from Talaromyces helicus SCSIO41311, which was collected in the South China Sea. 41 Fumigatin oxide had been previously isolated from Aspergillus fumigatus , 42 but the absolute configuration was reported for the first time.…”

Section: Epoxyquinonesmentioning

confidence: 99%

Natural epoxyquinoids: isolation, biological activity and synthesis. An update

Shcherbinin,

Nasibullina,

Mendogralo

et al. 2023

Org. Biomol. Chem.

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“…[7] Cong and co-workers isolated chaetominine B from Talaromyces helicus SCSIO41311. [8] In 2022, Li and co-workers accomplished a task of great significance. They isolated poloncosidins G-K and poloncosidins A-F from P. polonicum CS-252, which exhibited antimicrobial activities against human-and aquapathogenic microbes.…”

Section: Introductionmentioning

confidence: 99%

“…Li and co‐workers obtained chevalinulins A and B from A. chevalieri CS‐122, which exhibited significant in vivo proangiogenic activity [7] . Cong and co‐workers isolated chaetominine B from Talaromyces helicus SCSIO41311 [8] . In 2022, Li and co‐workers accomplished a task of great significance.…”

Section: Introductionmentioning

confidence: 99%

New Olimycins from a Cold‐Seep‐Derived Streptomyces olivaceus

Dong

Jin

Wang

et al. 2023

Chemistry & Biodiversity

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Cold‐seeps are areas of the ocean floor in which hydrogen sulfide and methane are released into the open water. The cold‐seep microbes are an emerging source of novel bioactive natural products. Four new ansa‐ring opened linear ansamycin analogues, named olimycins E−H (1–4) were isolated from the cold‐seep‐derived Streptomyces olivaceus OUCLQ19‐3. The planar and stereochemical structures of the isolated compounds were elucidated based on extensive MS and NMR spectroscopic analyses together with ECD calculations.

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Anti-inflammatory alkaloids from the cold-seep-derived fungus Talaromyces helicus SCSIO41311

Cited by 7 publications

References 25 publications

Research on Secondary Metabolites From the Soft Coral-Associated Fungus Aspergillus sydowii SCSIO41203 and Their Bioactivities

Research on Secondary Metabolites From the Soft Coral-Associated Fungus Aspergillus sydowii SCSIO41203 and Their Bioactivities

Natural epoxyquinoids: isolation, biological activity and synthesis. An update

New Olimycins from a Cold‐Seep‐Derived Streptomyces olivaceus

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