New Olimycins from a Cold‐Seep‐Derived Streptomyces olivaceus

Abstract

Cold‐seeps are areas of the ocean floor in which hydrogen sulfide and methane are released into the open water. The cold‐seep microbes are an emerging source of novel bioactive natural products. Four new ansa‐ring opened linear ansamycin analogues, named olimycins E−H (1–4) were isolated from the cold‐seep‐derived Streptomyces olivaceus OUCLQ19‐3. The planar and stereochemical structures of the isolated compounds were elucidated based on extensive MS and NMR spectroscopic analyses together with ECD calculations.