Anti-inflammatory activity on LPS-stimulated dendritic cells of lupanetype triterpenoids from the leaves of Acanthopanax koreanum

Abstract

Acanthopanax koreanum is well known herb in traditional Korean, Chinese, and Japanese anti-inflammatory action without any adverse effects. In the current study, we investigated the inhibitory effects of isolated compounds 1-13 from the leaves of A. koreanum on the lipopolysaccharide-stimulated production of pro-inflammatory cytokines in bone marrow-derived dendritic cells. Of these lupane-type triterpenoids, 1 exhibited particularly high inhibitory effect on lipopolysaccharide-stimulated TNF-α, IL-6, and IL-12 production with the values ranging from 45.0 to 84.5% at a concentration of 50 μM. These results warrant further studies concerning the potential anti-inflammatory benefits of medicinal foods containing the leaves of A. koreanum.

Quantitative determination of 15 bioactive triterpenoid saponins in different parts of Acanthopanax henryi by HPLC with charged aerosol detection and confirmation by LC–ESI‐TOF‐MS

“…are rich in saponins , flavonoids , phenolics , terpenes , lignans , and other compounds . Various species including Acanthopanax senticosus, Acanthopanax gracilistylus , and Acanthopanax koreanum are particularly rich in saponins, which are considered to be the chemical markers of Acanthopanax .…”

Acetylcorynoline Impairs the Maturation of Mouse Bone Marrow-Derived Dendritic Cells via Suppression of IκB Kinase and Mitogen-Activated Protein Kinase Activities

“…Thus, an active field of study is the handling of DCs as pharmacological targets to search new biological modifiers of immune responses [14], [15], [16], [17], [18], [19], [20], [21], [22], [23].…”

Chemical Constituents of the Rhizome of Eleutherine bulbosa and Their Inhibitory Effect on the Pro-Inflammatory Cytokines Production in Lipopolysaccharide-Stimulated Bone Marrow-derived Dendritic Cells

“…However, only two compounds 4 and 5 exhibited moderate inhibitory activity on the TNF-α production with IC 50 values of 61.2 ± 1.5 and 39.6 ± 2.0 μM. (-)-Hongconin (4), eleutherin (5), and isoeleutherin (6) isolated from Eleutherine americana also exhibited potent inhibitory activity on nitric oxide production LPS-activated mouse RAW 264.7 macrophage cell-line. 13 To the best our knowledge, this is the first report on anti-inflammatory activities of E. bulbosa and its chemical components.…”

“…One of the well-known drugs, aspirin was discovered based on the known analgesic and antipyretic properties of the bark of willow-tree since 400 BC. 4 Recently, we have focused on a number of medicinal plants with antiinflammatory activities and found some of them to possess the anti-inflammatory active compounds such as Acanthopanax koreanum 5 and Hedychium coronarium.…”