Chemical Constituents of the Rhizome of Eleutherine bulbosa and Their Inhibitory Effect on the Pro-Inflammatory Cytokines Production in Lipopolysaccharide-Stimulated Bone Marrow-derived Dendritic Cells

Toxicity and Anti-inflammatory Activities of an Extract of the Eleutherine bulbosa Rhizome on Collagen Antibody-induced Arthritis in a Mouse Model

“…Therefore, the development of safe, efficacious natural compounds has been considered. Previously, we reported that E. bulbosa showed potential anti-inflammatory effects by suppressing pro-cytokines such as IL-6, TNF-α, and IL-12 p40 in vitro and the main active compounds are found to be eleutherin, isoeleutherin and some eleutherinosides [4]. This study is the first report of the anti-arthritis activity of E. bulbosa in a CAIA mouse model.…”

“…Previously, we reported the isolation of a new compound dihydroeleutherinol-8-O-β-D-glucopyranoside (1) from a methanol extract of the rhizome of E. bulbosa, along with 14 other compounds: eleutherinol (2), eleutherinoside A (3), (-)-hongconin (4), eleutherin (5), isoeleutherin (6), eleuthoside C (7), eleutherineoside C (8), eleutherinoside B (9), (R)-7-acetyl-3,6dihydroxy-8-methyltetralone (10), eleuthoside A (11), eleuthoside B (12), eleutherinoside D (13), 3,6,8-trihydroxy-1-methylanthraquinone (14), and 2-acetyl-3,6,8-trihydroxy-1-methylanthraquinone (15). We also performed an in vitro evaluation of their inhibitory effects on the lipopolysaccharide-stimulated production of proinflammatory cytokines in bone marrow-derived dendritic cells [4]. Rheumatoid arthritis (RA) is an autoimmune disease that is characterized by synovial inflammation and cartilage and bone destruction.…”

New Naphthalene Derivatives from the Bulbs of Eleutherine americana with Their Protective Effect on the Injury of HUVECs

“…The absolute configuration of C-1 was established by ECD spectrum. In this experiment, the ECD spectrum (See Supplementary ) of 1 showed a positive Cotton effect around 310 nm, suggested the configurationat C-1 to be R [ 14 ] [(2 S ) dihydroeleutherinol-8- O - β - d -glucopyranoside, CD λ max 319 (−0.46)]. In addition, the optical rotation of 1 ( = +12.5) also suggested a stereochemistry at C-1 to be R by comparing the optical rotations of ( S ) isoeleutherol ( = −60.5) [ 13 ] and ( R ) (+)-Dihydroeleutherinol ( = +8.8) [ 6 ].…”

POTENSI EKSTRAK UMBI BAWANG DAYAK (Eleutherine palmifolia (L.) Merr.) DALAM MENCEGAH ULCERATIVE COLITIS PADA MENCIT YANG DIINDUKSI DSS (DEXTRAN SULFATE SODIUM)

“…Bagian yang dapat dimanfaatkan pada tanaman ini adalah umbinya. Secara empiris diketahui tanaman ini dapat berperan sebagai anti-kanker, anti-inflamasi (Le et al, 2013;Milackova et al, 2015), anti-mikroba (Ifesan et al, 2010;Temilade, 2009), dan menyembuhkan hipertensi (Saragih et al, 2014) serta diabetes melitus (Febrinda et al, 2014). Berdasarkan hasil penelitian terdahulu didapatkan bahwa umbi bawang dayak mengandung antioksidan, fenol, polifenol (Kuntorini dan Astuti, 2010), quercetin dan turunannya (Hara et al, 1997;Lee et al, 2015).…”