Anti-inflammatory activity of (+)-usnic acid

Vijayakumar, C S; Subramanian, Venkataraman; Reddy, M. Kannappa; Parvathavarthini, S; Kundu, Amit; Sukumar, E.

doi:10.1016/s0367-326x(00)00209-4

Cited by 121 publications

(74 citation statements)

References 9 publications

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“…1) is a secondary metabolite found in several species of lichens (Ingo 2002). This compound has received attention due is its wide variety of pharmacological activities, such as antimicrobial, analgesic and anti-inflammatory (Vijayakumar et al 2000;Luzina et al 2010). The insecticidal activity of the AU has also been the subject of scientific studies.…”

Section: Introductionmentioning

confidence: 99%

Molecular docking of Anopheles gambiae and Aedes aegypti glutathione S-transferases epsilon 2 (GSTE2) against usnic acid: an evidence of glutathione conjugation

Maia

Nadvorny

2014

Braz. arch. biol. technol.

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Section: Introductionmentioning

confidence: 99%

Molecular docking of Anopheles gambiae and Aedes aegypti glutathione S-transferases epsilon 2 (GSTE2) against usnic acid: an evidence of glutathione conjugation

Maia

Nadvorny

2014

Braz. arch. biol. technol.

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“…Cladonia, Ramalina, Usnea and others. The biological activities of usnic acid such as antiviral (Scirpa et al 1999), antifungal (Lauterwein et al 1995, Lawrey 1995, Cocchietto et al 2002, antiprotozoal (Fournet et al 1997), antiproliferative, antiherbivoral (Huneck 1999), analgesic (Vijayakumar et al 2000), hepatotoxic (Pramyothin et al 2004) have been reviewed by Ingolfsdottir (2002). Rankovic et al (2007) determined that usnic asid has the strongest antimicrobial activity.…”

Section: Discussionmentioning

confidence: 99%

Effects of some terricolous lichens [Cladonia rangiformis Hoffm., Peltigera neckerii Hepp ex Müll. Arg., Peltigera rufescens (Weiss) Humb.] on soil bacteria in natural conditions

Akpinar¹,

Öztürk²,

Si̇ni̇rtas³

2009

PLANT SOIL ENVIRON

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This paper is aimed to investigate the effects of some terricolous lichens on soil bacteria's growth in natural conditions. It is focused on species of bacteria and also on numbers of colony of soil specimens that were taken from substrates of three different terricolous lichen species. Peltigera rufescens (Weiss) Humb., which has not secondary metabolites, did not show an inhibition effect on soil bacteria. However, Peltigera neckerii Hepp ex Müll. Arg., which has secondary metabolites, has a negative effect on soil bacteria's growth. Besides, it was observed that Cladonia rangiformis Hoffm., which has many kinds of secondary metabolites, has the highest inhibition effect among the studied species. For this reason, we think that in the next researches, it is convenient to investigate elaborately by soil analysis the effect of lichen's secondary metabolites that have an effect on soil mineralization, on soil bacteria's growth.

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“…Usnic acid is widely distributed in species of Cladonia (Cladoniaceae), Usnea (Usneaceae), Lecanora (Lecanoraceae), Ramalina (Ramalinaceae), Evernia, Parmelia (Parmeliaceae), and other lichen genera (Ingólfsdóttir, 2002). Studies have been conducted in which the antiinflammatory activity of (+)-usnic acid was compared to that of ibuprofen using the rat paw edema assay (acute effects) and the cotton pellet assay (chronic effects) (Vijayakumar et al, 2000). Usnic acid and the depside diffractaic acid were identified as active components of an Usnea diffracta Vain.…”

Section: Introductionmentioning

confidence: 99%