Anti-inflammatory activity of phenolic compounds from the whole plant of Scutellaria indica

Cuong, To Dao; Hung, Tran Manh; Lee, Joo-Sang; Weon, Kwon-Yeon; Woo, Mi Hee; Min, Byung Sun

doi:10.1016/j.bmcl.2014.12.055

Cited by 28 publications

(25 citation statements)

References 22 publications

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“…Phenolics including alkenyl phenols are essential compounds for the suppression of inflammation among phytochemicals. Cuong et al studied the anti-inflammatory effects of phenolic compounds, and the results showed a strong inhibitory on NO production of isolated compounds because of the presence of the conjugated double bond of the olefinic group, and the 3,4-hydroxylation(s) of benzene ring gave favorable results [31,32,40]. In our study, bavinol A (4), which belongs to the alkenyl phenol class, exhibited the strongest inhibitory on NO production among the isolated compounds.…”

Section: No Production Inhibition and The Cell Viability Assaysupporting

confidence: 51%

“…In our study, bavinol A (4), which belongs to the alkenyl phenol class, exhibited the strongest inhibitory on NO production among the isolated compounds. However, the inhibitory activities on NO production of bavinol A (4) were weaker than active compounds presumably because of the lack of 3-hydroxylation of the benzene ring [31,32,40]. Compound 5 (transphytol) containing the conjugated double bond of the olefinic group in the structure also exhibited a strong inhibitory on NO production.…”

Section: No Production Inhibition and The Cell Viability Assaymentioning

confidence: 99%

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Anti-Inflammatory Compounds from Vietnamese Piper bavinum

Hoang

Nguyen

Doan

et al. 2020

Journal of Chemistry

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This study reports the anti-inflammatory activity-guided fractionation of the aerial part of Piper bavinum C. CD. (Piperaceae) that led to the isolation of eight secondary metabolites (1–8). The chemical structures of 1–8 were established mainly by NMR and mass spectra. Compound 5 was isolated from P. bavinum for the first time. All the isolated compounds were evaluated against LPS-induced NO production in macrophage RAW 264.7 cells in vitro. Among them, compound 4 showed the most potent inhibitory activity against the LPS-induced NO production with an IC50 value of 5.2 μM followed by compound 5 that inhibited NO production with an IC50 value of 13.5 μM. In the protein levels, compound 4 suppressed LPS-induced COX-2 and iNOS expressions in a dose-dependent manner. The results suggested that P. bavinum and its constituents might exert anti-inflammatory effects.

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Section: No Production Inhibition and The Cell Viability Assaysupporting

confidence: 51%

Section: No Production Inhibition and The Cell Viability Assaymentioning

confidence: 99%

Anti-Inflammatory Compounds from Vietnamese Piper bavinum

Hoang

Nguyen

Doan

et al. 2020

Journal of Chemistry

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“…The 13 C‐NMR ((D 6 )DMSO, 125 MHz) and DEPT spectra gave 25 carbon resonances, including one methyl, three methylenes (sp 3 hybridized), thirteen methines (eight sp 2 hybridized and five sp 3 hybridized), and eight quaternary carbons (sp 2 hybridized). Detailed analyses of above 25 carbon signals displayed that 15 carbons were due to one flavonoid skeleton, six carbons to one glucuronate moiety, and four carbons to one butyl group, respectively. In the HMBC experiment ( Figure ), the long‐range correlations from δ (H) 12.83 (1H, s, 5‐OH) to δ (C) 161.6 (C(5)), δ (H) 5.33 (1H, d, J = 7.3, H–C(1″)) to δ (C) 163.1 (C(7)) and δ (H) 4.04 – 4.15 (2H, m, H–C(1‴)) to δ (C) 169.2 (C(6″)) confirmed the hydroxy group, glucuronate ester moiety, and butyl group were attached to C(5), C(7), and C(6″), respectively.…”

Section: Resultsmentioning

confidence: 99%

New Flavonoid Glucuronate Esters with Anti‐inflammatory Activities from Scutellaria regeliana

Han

Xiao

Xiang

et al. 2018

Chemistry & Biodiversity

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Two new flavonoid glucuronate esters, named scuregeliosides A and B (1 and 2), as well as three known ones, chrysin-7-O-β-d-glucuronic acid methyl ester (3), 5,7,4'-trihydroxyflavone-8-O-β-d-glucuronic acid methyl ester (4) and apigenin-7-O-β-d-glucuronic acid ethyl ester (5), were isolated from the ethanolic extract of the whole plant of Scutellaria regeliana. Their chemical structures were elucidated on the basis of comprehensive spectroscopic analyses. Five compounds were screened for anti-inflammatory activity in vitro. As the results, the inhibition rates of release of β-glucuronidase from rat polymorphonuclear leukocytes were in the range of 42.2 - 47.1% at a concentration of 10 μm.

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“…Phenolic compounds, broadly distributed in the plant kingdom, are a major class of bioactive components. Phenols and flavonoids have drawn increasing attention due to their marked effects in the prevention of various diseases as these possess diverse biological activities, for instance, antioxidant [43], antitumor [44], antiulcer [45], anti-inflammatory [43,46] and antidepressant activities [47,48].…”

Section: Phenol and Flavonoid Estimationmentioning

confidence: 99%

Screening of Total Phenol and Flavonoid Content in Different Cytotypes of Two Species of Achyranthes Linn. From Western Himalaya, India

Saggoo

Lovleen

2017

Int J Pharm Pharm Sci

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Objective: Genus Achyranthes Linn. belonging to family Amaranthaceae consists of six species. The present study was undertaken to screen the phenolic components in the different cytotypes of two species of Genus Achyranthes Linn. growing in western Himalaya, India.Methods: Methanol extract of leaves was used to determine the total phenol and flavonoid contents in different cytotypes of A. aspera Linn. and A. bidentata Blume by spectrophotometric method. Total phenol content was expressed as mg gallic acid g -1 phenol and total flavonoid content as mg quercetin g -1Results: Hexaploid plants of A. aspera Linn. possess the higher amount of phenol (9.16±0.84 mg/g) and flavonoid (78.36±1.63 mg/g) constituents in the methanol extract of leaves as compared to its dodecaploid counterparts (7.86±0.08 mg/g and 70.20±1.81 mg/g respectively). Similarly, phenol and flavonoid content is found to be more in the methanol extract of leaves of hexaploid plants of A. bidentata Blume (11.93±0.59 mg/g and 115.92±1.32 mg/g respectively) as compared to its dodecaploid counterparts (9.46±0.75 mg/g and 107.76±0.94 mg/g respectively). Further, RP-HPLC analysis of gallic acid revealed that higher amount of gallic acid is present in dodecaploid plants of A. aspera Linn. (1.04±0.02 mg/g) and A. bidentata Blume (1.34±0.03 mg/g) as compared to hexaploid counterparts (1.01±0.01 mg/g and 1.22±0.05 mg/g respectively).flavonoid using the standard curves. Further, gallic acid content in methanol extracts of leaves was determined by RP-HPLC method using C-18 column, employing 0.01% (v/v) orthophosphoric acid: acetonitrile (98:2 v/v) as mobile phase at a flow rate of 1 ml/min with ultraviolet (UV) detection at 272 nm. Conclusion:The present investigation revealed that A. aspera Linn. and A. bidentata Blume plants show immense intraspecific variability in their phenolic components. Hence there is need to evaluate germplasm to select superior genotype for medicinal and conservation purpose.

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Anti-inflammatory activity of phenolic compounds from the whole plant of Scutellaria indica

Cited by 28 publications

References 22 publications

Anti-Inflammatory Compounds from Vietnamese Piper bavinum

Anti-Inflammatory Compounds from Vietnamese Piper bavinum

New Flavonoid Glucuronate Esters with Anti‐inflammatory Activities from Scutellaria regeliana

Screening of Total Phenol and Flavonoid Content in Different Cytotypes of Two Species of Achyranthes Linn. From Western Himalaya, India

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