Anti-inflammatory Activity of Myricetin Isolated fromMyrica rubraSieb. et Zucc. Leaves

Abstract

MYRICA RUBRA Sieb. et Zucc. leaves are commonly used in folk medicine to treat inflammatory disorders in China. Present studies on the anti-inflammatory effect of myricetin from MYRICA RUBRA Sieb. et Zucc. leaves was evaluated with various IN VIVO models of both acute and chronic inflammations such as xylene-induced ear edema, acetic acid-induced vascular permeability, carrageenan-induced paw edema, leukocyte migration assay, and cotton pellet granuloma models. Myricetin showed a significant inhibition on ear edema and hind paw edema caused by xylene and carrageenan, respectively. Furthermore, it also inhibited the increase in capillary permeability induced by the production of acetic acid in the human body. Myricetin significantly decreased the serum levels of MDA and, in turn, increased the serum levels of SOD in the carrageenan-induced paw edema model. Concurrently, myricetin also significantly decreased leukocyte count. During chronic inflammation, myricetin inhibited the formation of granuloma tissue. These results, collectively, demonstrate that myricetin possesses a potent anti-inflammatory function on acute and chronic inflammation. Its anti-inflammatory mechanisms are probably associated with the inhibition of antioxidant activity. These results also support the claims of traditional Chinese medicine practitioners about the use of MYRICA RUBRA Sieb. et Zucc. leaves in the treatment of inflammatory diseases.

Protective effect of myricetin in dextran sulphate sodium-induced murine ulcerative colitis

“…Inhibiting the action of endogenous IL-1β or IL-6 attenuates acute and chronic experimental colitis and their systemic complications (23)(24)(25). Previous studies have shown that the anti-inflammatory mechanisms of myricetin are most likely associated with the inhibition of antioxidant activity (26). Therefore, myricetin may exert its effects in DSS colitis through its antioxidant effect.…”

Evaluation of anti-inflammatory activity and standardisation of hydro-methanol extract of underground tuber ofDioscorea alata

“…The dietary phenol PCA increases immunoglobulin levels and decreases TNF-a levels in vivo (Pragasam et al 2013), in addition, it inhibits thromboxane B 2 production and LPS-induced PGE 2 generation in vitro (Luceri et al 2007). MY has demonstrated anti-inflammatory activity under xyleneinduced ear edema, acetic acid-induced vascular permeability, carrageenan-induced paw edema, leukocyte migration, and cotton pellet granuloma models (Wang et al 2010). Kim et al (2009) (Wang et al 2010).…”

“…MY has demonstrated anti-inflammatory activity under xyleneinduced ear edema, acetic acid-induced vascular permeability, carrageenan-induced paw edema, leukocyte migration, and cotton pellet granuloma models (Wang et al 2010). Kim et al (2009) (Wang et al 2010). 4HBA and SA are benzoic acid derivatives.…”

Natural Compounds: Molecular Weapons against Leukemia’s

“…Several compounds have been extracted from the plant and some of them are known for their antioxidative and antiinflammatory properties [35] or for their in vitro anticancer potential in some human cancer cell lines such as adenocarcinoma and prostate cancer cells [36], glioblastoma and melanoma cells [37].…”