Anti‐inflammatory activity of mushroom‐derived hispidin through blocking of NF‐κB activation

Abstract

These findings suggest that hispidin exhibits anti-inflammatory activity through suppressing ROS mediated NF-κB pathway in mouse macrophage cells.

Bioactivities and Health Benefits of Mushrooms Mainly from China

“…Moreover, hispidin reduced iNOS protein expression and the generation of reactive oxygen species (ROS) in the LPS-induced cells, but phosphorylation of mitogen-activated protein kinases was not affected. These findings indicated that hispidin presented anti-inflammatory activity by suppressing ROS mediated NF-κB pathway [35]. Besides, the anti-inflammatory effect of the polysaccharides isolated from golden needle mushroom was investigated in burned rats.…”

“…Hispidin, a polyphenol component mainly derived from medicinal Phellinus mushroom species, has been proved to possess distinct biological properties [35]. The research showed that hispidin inhibited transcriptional activity of NF-κB in a dose-dependent manner.…”

Valorization of spent shiitake substrate for recovery of antitumor fungal sterols by ultrasound-assisted extraction

“…Cytotoxic activity of fungal sterol extracts, together with ergosterol and β‐sitosterol as positive control, against Caco‐2, SMMC‐7721, and HepG2 cell lines was determined using MTT tetrazolium reduction assay (Shao, Jeong, Kim, & Lee, ). Briefly, the cells were seeded onto 96‐well plates at a density of 5 × 10 4 cells/well in 100‐μL medium and cultured until cell attachment.…”

“…HepG2 cell lines was determined using MTT tetrazolium reduction assay (Shao, Jeong, Kim, & Lee, 2015). Briefly, the cells were seeded…”

Screening of Anti-inflammatory Compound-producing Wild Yeasts and Their Microbiological Characteristics

“…따라서 염증 반응에서 염증유발물질인 interferon-, interleukin1- 등의 cytokine과 nitric oxide synthase, cycloxygense-2 등의 발 현 또는 생성 억제를 통하여 nitric oxide와 prostaglandin E 2 의 생성을 억제시키므로 항염증 효과를 확인할 수 있다. 지금까지 항염증 물질생산에 관한 연구로는 적하수오 [4], 홍삼 [5], 홍 자단 [6] 등과 목질진흑버섯 [7,8], 차가버섯(자작나무시루뻔버섯) [9,10], 말굽버섯 [11] 등의 버섯 [1,3,12] 및 키위 [13], 밀배아유 [14], 진두발 [15] 등 주로 약용식물과 천연물 등의 추출 물에서 항염증 효과에 관하여 연구, 보고되었다. 한편, 효모는 진균류의 일종으로 최근 이들 로부터 다양한 대사산물의 생산과 이들에 대한 응용성들이 연구되어 항고혈압성 안지오텐신 전환효소 저해물질 [16][17][18]과 항치매성 B-secretase 저해물질 [19]과 acetylcholine esterase 저 해 물질 [20], 혈전용해 활성물질 [21], 혈관신생 억제물질 [22], 미백성 Tyrosinase 저해물질 YM, PD, YPD, 비타민 무함유 배지 등에서 잘 생육하였다.…”