Anti-inflammatory activity of methyl palmitate and ethyl palmitate in different experimental rat models

Assessment of anti-inflammatory, antinociceptive, immunomodulatory, and antioxidant activities ofCajanus cajanL. seeds cultivated in Egypt and its phytochemical composition

“…Furthermore, Kale and Dhake (2013) proved that b-sitosterol and stigmasterol, either in free or ester forms have significant anti-inflammatory activity. In addition, palmitic acid esters were reported as inflammatory cell inhibitors and Saeed et al (2012) found that palmitic acid esters reduced carrageenaninduced rat paw edema and diminished prostaglandin E2 level in the inflammatory exudates. Mathur et al (2011) found that 9,12-octadecadienoic acid exhibited strong antioxidant activity with an IC 50 value of 45.65 mg/ml and reduced 85% in paw edema.…”

Anti-inflammatory effect of natural and semi-synthetic phthalides

“…This release can contribute to the pathogenesis of inflammation (Klebanoff, 2005). MPO is considered a quantitative marker for cell infiltration in skin, mainly neutrophils, (Bradley et al, 1982;Klinke et al Q2 ., 2011;Laight et al, 1994;Saeed et al, 2012). The histological examination let us confirm the significant reduction in the thickness of ears treated with TPA and the semi-synthetic phthalides, and the reduction in the leucocyte recruitment; we could correlate the result obtained from the recruitment of leukocytes, with the activity of the MPO enzyme, the MPO is found also in monocytes but according to Bradley et al (1982) the contribution of this represents approximately 0.06%.…”

“…At a dose of 1 μmol/ear, these three compounds exhibited local anti-inflammatory effects by significantly reducing ear punch weight. A key cellular event in inflammation is the accumulation of polymorphonuclear leukocytes (PMN), which primarily comprise neutrophils (Rao et al, 1993;Sacca et al, 1997;Saeed et al, 2012). PMN stimulation, neutrophils and monocytes, lead to cellular release of MPO and other lysosomal enzymes (Klebanoff, 2005;Susuki et al, 1983;Prokopowicz et al, 2012).…”

<i>In silico</i> analysis of compounds characterized from ethanolic extract of <i>Cucurbita pepo</i> with NF-κB-inhibitory potential

“…These compounds, as well as other structurally similar compounds like hexadecanoic acid, methyl strearate and phytol, have been reported to be present in the ethanolic extracts of other antiinflammatory plants (Aparna et al, 2012;Ezhilan and Neelamegam, 2012;Saeed et al, 2012;Marimuthu et al, 2013;Silva et al, 2014). Silva et al (2014) reported that phytol inhibits inflammation by reducing cytokine production and oxidative stress while Saeed (2012) reported that the derivatives of hexadecanoic acid prevented lipopolysaccharide-induced inflammation by suppressing the production of cytokines and NF-κB. The anti-inflammatory property of this compound has been linked to their structures (Aparna et al, 2012).…”