Assessment of anti-inflammatory, antinociceptive, immunomodulatory, and antioxidant activities of<i>Cajanus cajan</i>L. seeds cultivated in Egypt and its phytochemical composition

Hassan, Emad M.; Matloub, Azza A.; Aboutabl, Mona E.; Ibrahim, Nabaweya A.; Mohamed, S. M.

doi:10.3109/13880209.2015.1078383

Cited by 40 publications

(30 citation statements)

References 30 publications

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“…Recently, anti-inflammatory, antinociceptive, immunomodulatory and antioxidant activities of Cajanus cajan seeds cultivated in Egypt were also reported (Hassan et al. 2016 ). However, little information in toxicity and safety evaluation on pharmacologically active extracts from C. cajan is reported.…”

Section: Introductionmentioning

confidence: 99%

Acute and sub-chronic toxicity of Cajanus cajan leaf extracts

Tang

Tian

Cai

et al. 2017

Pharmaceutical Biology

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Context: The leaves of Cajanus cajan (L.) Millsp. (Fabaceae) have diverse bioactivities, but little safety data are reported. Objective: This study examines the toxicological profiles of C. cajan leaf extracts. Materials and methods: The leaves were extracted by water or 90% ethanol to obtain water or ethanol extract (WEC or EEC). EEC was suspended in water and successively fractionated into dichloroform and n-butanol extracts (DEC and BEC). Marker compounds of the extracts were monitored by high-performance liquid chromatography (HPLC). Kunming mice were administered with a single maximum acceptable oral dose (15.0 g/kg for WEC, EEC and BEC and 11.3 g/kg for DEC) to determine death rate or maximal tolerated doses (MTDs). In sub-chronic toxicity investigation, Sprague-Dawley rats were orally given WEC or EEC at 1.5, 3.0 or 6.0 g/kg doses for four weeks and observed for two weeks after dosing to determine toxicological symptoms, histopathology, biochemistry and haematology. Results: Flavonoids and stilbenes in the extracts were assayed. In acute toxicity test, no mortality and noted alterations in weight and behavioural abnormality were observed, and the maximum oral doses were estimated as MTDs. In sub-chronic toxicity study, no mortality and significant variances in haematological and biochemical parameters or organ histopathology were observed, but increased kidney weight in 3.0 g/kg WEC-or 3.0 and 6.0 g/kg EEC-treated female rats, and reduced testes and epididymis weight in EEC-treated male rats were recorded. These changes returned to the level of control after recovery period. Conclusion: Acute and sub-chronic toxicity of Cajanus cajan leaf extracts was not observed. ARTICLE HISTORY

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Section: Introductionmentioning

confidence: 99%

Acute and sub-chronic toxicity of Cajanus cajan leaf extracts

Tang

Tian

Cai

et al. 2017

Pharmaceutical Biology

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“…In a recent study, the pigeon pea extract inhibited carrageenan-induced inflammation by 85 and 95%, respec tively. This was accompanied by a decrease of TNF-α and IL-6, as well as significant decrease in IgG serum levels (Hassan et al 2015).…”

Section: Anti-inflammatorymentioning

confidence: 84%

Role of pigeon pea (Cajanus cajan L.) in human nutrition and health: A review

Talari

Shakappa

2018

AJDFR

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Legumes and cereals are good, relatively inexpensive, sources of proteins and energy for third world countries, including India. India is a major pulse producing country, sharing 36 and 28% of total area and production of these crops. Pigeon pea (Cajanus cajan L.) is widely consumed in the form of dhal as an economical source of protein. It is a dense source of nutrients, but its nutritional elements are masked by some anti-nutritional factors decreased by different processing methods. The non-nutritive compounds of pigeon pea have been investigated for their role in the enhancement of the antioxidant and anti carcinogenic effects. Recent evidences suggest that pigeon pea bioactive compounds play a vital role in modulating the gut micribiota hence, can reduce inflammation. The Prebiotic potential of non digestible raffinose family oligosaccharides has also been investigated in animal models. Research on pigeon pea prebiotic oligosaccharide and health benefits is scanty and some research regarding this novel approach remains inconclusive and there is still much to be studied. This review article focuses on the nutritional, anti-nutritional factors bioactive compounds and other health benefits of pigeon pea.

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“…trans -Phytol isolated from the stem of Sinocalamus affinis potently inhibited estrogen biosynthesis for the prevention and treatment of estrogen-dependent human cancer and may be a new source of tissue selective aromatase modulators (Guo et al, 2014). trans -Phytol identified in Cajanus cajan L. seeds, inhibited carrageenan-induced and decreased pro-inflammatory cytokine TNF- α and IL-6 in vivo and in vitro (Hassan et al, 2015). The commercial phytol reduced the number of contortions at doses of 25–200 mg/kg group in the acetic acid-induced writhing test in vivo .…”

Section: Discussionmentioning

confidence: 99%

Attenuation of antigen-specific T helper 1 immunity by Neolitsea hiiranensis and its derived terpenoids

Cheng

Chen

Lin

et al. 2016

PeerJ

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BackgroundT cells play a pivotal role in the adaptive immunity that participates in a wide range of immune responses through a complicated cytokine network. Imbalance of T-cell responses is involved in several immune disorders. Neolitsea species, one of the biggest genera in the family Lauraceae, have been employed widely as folk medicines for a long time in Asia. Previous phytochemical investigations revealed the abundance of terpenes in the leaves of N. hiiranensis, an endemic Neolitsea in Taiwan, and demonstrated anti-inflammatory activities. However, the effect of N. hiiranensis on the functionality of immune cells, especially T cells, is still unclear. In this study, we utilize in vitro and in vivo approaches to characterize the effects of leaves of N. hiiranensis and its terpenoids on adaptive immune responses.MethodsDried leaves of N. hiiranensis were extracted three times with cold methanol to prepare crude extracts and to isolate its secondary metabolites. The ovalbumin (OVA)-sensitized BALB/c mice were administrated with N. hiiranensis extracts (5–20 mg/kg). The serum and splenocytes of treated mice were collected to evaluate the immunomodulatory effects of N. hiiranensis on the production of OVA-specific antibodies and cytokines. To further identify the N. hiiranensis-derived compounds with immunomodulatory potentials, OVA-primed splenocytes were treated with compounds isolated from N. hiiranensis by determining the cell viability, cytokine productions, and mRNA expression in the presence of OVA in vitro.ResultsCrude extracts of leaves of N. hiiranensis significantly inhibited IL-12, IFN-γ, and IL-2 cytokine productions as well as the serum levels of antigen-specific IgM and IgG2a in vivo. Two of fourteen selected terpenoids and one diterpenoid derived from the leaves of N. hiiranensis suppressed IFN-γ in vitro. In addition, β-caryophyllene oxide attenuated the expression of IFN-γ, T-bet, and IL-12Rβ2 in a dose-dependent manner. N. hiiranensis-derived β-caryophyllene oxide inhibited several aspects of adaptive immune responses, including T-cell differentiation, IFN-γ production, and Th1-assocaited genes.ConclusionAs IFN-γ is the key cytokine secreted by T helper-1 cells and plays a pivotal role in Th1 immune responses, our results suggested that the N. hiiranensis and its terpenoids may possess potential therapeutic effects on Th1-mediated immune disorders.

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Assessment of anti-inflammatory, antinociceptive, immunomodulatory, and antioxidant activities ofCajanus cajanL. seeds cultivated in Egypt and its phytochemical composition

Cited by 40 publications

References 30 publications

Acute and sub-chronic toxicity of Cajanus cajan leaf extracts

Acute and sub-chronic toxicity of Cajanus cajan leaf extracts

Role of pigeon pea (Cajanus cajan L.) in human nutrition and health: A review

Attenuation of antigen-specific T helper 1 immunity by Neolitsea hiiranensis and its derived terpenoids

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