Anti-inflammatory activity of leaf extract and fractions of Bursera simaruba (L.) Sarg (Burseraceae)

Noguera, B.; Díaz, E; García, Marina; Feliciano, Arturo San; López-Pérez, Jose Luis; Israel, A

doi:10.1016/j.jep.2004.02.009

Cited by 23 publications

(20 citation statements)

References 9 publications

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“…The data reported demonstrated that bursehernin ( 18 ) was slightly weaker than β-carotene, which is commonly used in cancer prevention studies [ 147 ] so it might be a valuable antitumor promoter. Bursehernin ( 18 ) is able to inhibit the growth of Neisseria gonorrhoeae [ 148 ]. The trypanocidal activity of racemic mixtures of cis - and trans -bursehernin was evaluated in vitro against trypomastigote forms of two strains of Trypanosoma cruzi , and results showed that the racemic cis -stereoisomer was inactive, whereas the racemic trans -stereoisomer displayed trypanocidal activity, with an IC 50 ~89.3 μM.…”

Section: Genus Burseramentioning

confidence: 99%

An Ethnopharmacological, Phytochemical and Pharmacological Review on Lignans from Mexican Bursera spp.

2018

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The genus Bursera belongs to the family Burseraceae and has been used in traditional Mexican medicine for treating various pathophysiological disorders. The most representative phytochemicals isolated from this genus are terpenoids and lignans. Lignans are phenolic metabolites known for their antioxidant, apoptotic, anti-cancer, anti-inflammatory, anti-bacterial, anti-viral, anti-fungal, and anti-protozoal properties. Though the genus includes more than 100 species, we have attempted to summarize the biological activities of the 34 lignans isolated from selected Mexican Bursera plants.

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Section: Genus Burseramentioning

confidence: 99%

An Ethnopharmacological, Phytochemical and Pharmacological Review on Lignans from Mexican Bursera spp.

2018

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“…[ 22 ] For the Bursera genus, the n -hexane extract and secondary fractions of B. simaruba exhibited anti-inflammatory activity in a mouse paw edema model. [ 23 ]…”

Section: Resultsmentioning

confidence: 99%

Anti-inflammatory and cytotoxic activities of Bursera copallifera

et al. 2015

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Background:The plant species Bursera copallifera (DC) bullock is used in traditional medicine to treat inflammation. The leaves of this plant can be prepared as an infusion to treat migraines, bronchitis, and dental painObjective:The purpose of this study was to determine the anti-inflammatory and cytotoxic activities of organic extracts from the stems, stem bark, and leaves of B. copallifera, which was selected based on the knowledge of its traditional use.Materials and Methods:We evaluated the ability of extracts to inhibit mouse ear inflammation in response to topical application of 12-O tetradecanoylphorbol-13-acetate. The extracts with anti-inflammatory activity were evaluated for their inhibition of pro-inflammatory enzymes. In addition, the in vitro cytotoxic activities of the organic extracts were evaluated using the sulforhodamine B assay.Results:The hydroalcoholic extract of the stems (HAS) exhibited an anti-inflammatory activity of 54.3% (0.5 mg/ear), whereas the anti-inflammatory activity of the dichloromethane-methanol extract from the leaves (DMeL) was 55.4% at a dose of 0.1 mg/ear. Methanol extract from the leaves (MeL) showed the highest anti-inflammatory activity (IC50 = 4.4 μg/mL), hydroalcoholic extract of leaves, and DMeL also reduce the enzyme activity, (IC50 = 6.5 μg/mL, IC50 = 5.7 μg/mL), respectively, from stems HAS exhibit activity at the evaluated concentrations (IC50 =6.4 μg/mL). The hydroalcoholic extract of the stems exhibited the highest cytotoxic activity against a breast adenocarcinoma cell line (MCF7, IC50 = 0.90 μg/mL), whereas DMeL exhibited an IC50 value of 19.9 μg/mL.Conclusion:In conclusion, extracts from leaves and stems inhibited cyclooxygenase-1, which is the target enzyme for nonsteroidal anti inflammatory drugs, and some of these extracts demonstrated substantial antiproliferative effects against the MCF7 cell line. These results validate the traditional use of B. copallifera.

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“…It is considered to be vulnerary and healing (Asprey and Thornton, 1955a). Phytochemical studies available for this plant demonstrate the presence of some compounds belonging to the lignan (picropolygamain) and triterpenoid (lupeol, epilupeol, a and b-amyrin) groups with lupeol as the main bactericidal compound (Camporese et al, 2003;Carretero et al, 2008;Maldini et al, 2009;Noguera et al, 2004;Peraza-Sanchez and Pena-Rodriguez, 1992).…”

Section: Resultsmentioning

confidence: 99%

Antifungal Activity of 10 Guadeloupean Plants

Biabiany

Roumy

Hennebelle

et al. 2012

Phytotherapy Research

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Screening of the antifungal activities of ten Guadeloupean plants was undertaken to find new extracts and formulations against superficial mycoses such as onychomycosis, athlete's foot, Pityriasis versicolor, as well as the deep fungal infection Pneumocystis pneumonia. For the first time, the CMI of these plant extracts [cyclohexane, ethanol and ethanol/water (1:1, v/v)] was determined against five dermatophytes, five Candida species, Scytalidium dimidiatum, a Malassezia sp. strain and Pneumocystis carinii. Cytotoxicity tests of the most active extracts were also performed on an HaCat keratinocyte cell line. Results suggest that the extracts of Bursera simaruba, Cedrela odorata, Enterolobium cyclocarpum and Pluchea carolinensis have interesting activities and could be good candidates for developing antifungal formulations.

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Anti-inflammatory activity of leaf extract and fractions of Bursera simaruba (L.) Sarg (Burseraceae)

Cited by 23 publications

References 9 publications

An Ethnopharmacological, Phytochemical and Pharmacological Review on Lignans from Mexican Bursera spp.

An Ethnopharmacological, Phytochemical and Pharmacological Review on Lignans from Mexican Bursera spp.

Anti-inflammatory and cytotoxic activities of Bursera copallifera

Antifungal Activity of 10 Guadeloupean Plants

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