Anti-inflammatory Activity of Ketoprofen Gel on Carrageenan-Induced Paw Edema in Rats

Chi, Sang-Cheol; Jun, H. W.

doi:10.1002/jps.2600791106

Cited by 75 publications

(29 citation statements)

References 4 publications

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“…Such a medium presents the advantage of not dissolving Poloxamer 407 formulation. Thus, it does not necessitate any separating membrane or preheating of the sample (60,61,70). In addition, the use of a hydrophobic receptor medium has been presented as one, which better considers factors influencing drug partitioning (70).…”

Section: Nature Of the Receptor Mediummentioning

confidence: 99%

“…Molecules like diclofenac, ethanol, propylene glycol, and HCl reduce the gel strength and bioadhesive force and increase TsolYgel while others do the opposite (e.g., NaCl, Na 2 HPO 4 , NaH 2 PO 4 ) (50,52). As ethanol is often added in gel formulation to enhance solubility (60,61), preliminary studies must be carried out to specify influence of ethanol on Poloxamer 407 gel characteristics. Adding sodium alginate, polycarbophil or carbopol has been reported to lower gelation temperature (51), as well.…”

Section: Solygel Transition Temperaturementioning

confidence: 99%

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A Review of Poloxamer 407 Pharmaceutical and Pharmacological Characteristics

et al. 2006

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Poloxamer 407 copolymer (ethylene oxide and propylene oxide blocks) shows thermoreversible properties, which is of the utmost interest in optimising drug formulation (fluid state at room temperature facilitating administration and gel state above sol-gel transition temperature at body temperature promoting prolonged release of pharmacological agents). Pharmaceutical evaluation consists in determining the rheological behaviour (flow curve or oscillatory studies), sol-gel transition temperature, in vitro drug release using either synthetic or physiological membrane and (bio)adhesion characteristics. Poloxamer 407 formulations led to enhanced solubilisation of poorly water-soluble drugs and prolonged release profile for many galenic applications (e.g., oral, rectal, topical, ophthalmic, nasal and injectable preparations) but did not clearly show any relevant advantages when used alone. Combination with other excipients like Poloxamer 188 or mucoadhesive polymers promotes Poloxamer 407 action by optimising sol-gel transition temperature or increasing bioadhesive properties. Inclusion of liposomes or micro(nano)particles in Poloxamer 407 formulations offers interesting prospects, as well. Besides these promising data, Poloxamer 407 has been held responsible for lipidic profile alteration and possible renal toxicity, which compromises its development for parenteral applications. In addition, new findings have demonstrated immuno-modulation and cytotoxicity-promoting properties of Poloxamer 407 revealing significant pharmacological interest and, hence, human trials are in progress to specify these potential applications.

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Section: Nature Of the Receptor Mediummentioning

confidence: 99%

Section: Solygel Transition Temperaturementioning

confidence: 99%

A Review of Poloxamer 407 Pharmaceutical and Pharmacological Characteristics

et al. 2006

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“…Diclofenac (16 mg/kg) microbeads, commercial tablet or diclofenac powder was administered orally to each group 30 min after induction of inflammation, while water was administered to the control group. The paw size was measured at different time intervals and the percent swelling was determined using the equation [24]:…”

Section: Induction Of Inflammationmentioning

confidence: 99%

Design of cissus–alginate microbeads revealing mucoprotection properties in anti-inflammatory therapy

Okunlola

Odeku

Lamprecht

et al. 2015

International Journal of Biological Macromolecules

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“…Uniqueness in the structure, molecular weight and shape having high degree of control, are the parameters, which led to the synthesis of unimolecular micelles [1][2][3][4]. By molecular simulation many dendrimers have been synthesized fairly on a large scale and are characterized experimentally [5].…”

Section: Introductionmentioning

confidence: 99%

Biodistribution Study of Pegylated Ppi Dendrimer Loaded with Prednisolone for Prolonged Release

Karthikeyan¹,

O²,

rajKumar³

2017

Nano Res Appl

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PEGylated PPI dendritic scaffold was used for the delivery of an anti-leukemic drug, Prednisolone. The current study evolves and emerges the use PEGylated poly dendritic scaffold for the delivery of this drug. In this the prednisolone was loaded and synthesized with PEGylated PPI dendritic scaffold. Estimated the biodistribution of prednisolone in different vital organ was carriedout by HPLC method and the study was promising the distribution of drug candidate.

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Anti-inflammatory Activity of Ketoprofen Gel on Carrageenan-Induced Paw Edema in Rats

Cited by 75 publications

References 4 publications

A Review of Poloxamer 407 Pharmaceutical and Pharmacological Characteristics

A Review of Poloxamer 407 Pharmaceutical and Pharmacological Characteristics

Design of cissus–alginate microbeads revealing mucoprotection properties in anti-inflammatory therapy

Biodistribution Study of Pegylated Ppi Dendrimer Loaded with Prednisolone for Prolonged Release

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