Anti-inflammatory activity of extracts of root bark of &lt;i&gt;Securidaca longipedunculata&lt;/i&gt; fres (polygalaceae)

Okoli, C. O.; Akah, P. A.; Ezugworie, U.

doi:10.4314/ajtcam.v3i1.31139

Cited by 27 publications

(31 citation statements)

References 20 publications

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“…The crude methanol extract yield obtained in this study agreed with the crude methanol extract value of (10.9%) reported by Okoli et al (2006). The extract seems to have some anabolic effects considering the body weight of the control and the treated groups.…”

Section: Discussionsupporting

confidence: 77%

Effect of Securidaca longepedunculata root-bark methanol extract on testicular morphometry of New Zealand rabbits

Chika¹,

Luka²,

Azubuike³

2017

J. Vet. Med. Anim. Health

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The aim of this work was to determine the effect of the root-bark extract of Securidaca longepedunculata in the improvement of fertility in buck rabbits as envisioned by morphometric indices of the testes. Testicular morphometry of New Zealand rabbits was studied following treatment with different doses of the extract. The extract was administered per os in three doses of 0, 50 and 100 mg/kg body weight to three treatment groups of rabbits A, B, and C respectively for 29 days in a completely randomized designed (CRD). Eighteen mature buck rabbits between the ages of 18 and 24 months and with initial body weight (1.1 to 1.9 kg) were used. Each group comprised of three rabbits replicated twice. After the period of treatment, rabbits were weighed and sacrificed. Mean absolute paired testes weight, testes length and testes width were obtained and expressed relative to body weight at sacrifice. The results showed a significant difference in the mean relative paired testes weight, testes length and testes width between groups (p<0.05). The treated group given 50 mg/kg body weight of the extract had the highest mean absolute and relative paired testes weight of 3.325 ± 0.1349 a g and 0.2098 ± 0.0139 a % with mean absolute and relative testes length of 2.4522 ± 0.0250 a cm and 0.1538 ± 0.0040 a %. While the group given 100 mg/kg body weight of the extract had the lowest values of 2.634 ± 0.2762 b g and 0.1565 ± 0.0124 b % with mean absolute and relative paired testes length of 2.1600 ± 0.0807 b cm and 0.1299 ± 0.0039 b % respectively. It was concluded that administration of the extract at 50 mg/kg body weight yielded higher testicular parameters of buck rabbits. It was recommended that the use of the extract in bucks should be done with caution in relation to dose and length of treatment and that a detailed research should be carried out to evaluate the semen quality of bucks treated with 50 mg/kg the extract.

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Section: Discussionsupporting

confidence: 77%

Effect of Securidaca longepedunculata root-bark methanol extract on testicular morphometry of New Zealand rabbits

Chika¹,

Luka²,

Azubuike³

2017

J. Vet. Med. Anim. Health

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“…The methanol extracts, petroleum ether and methanol fractions obtained from solvent extraction of the root bark were also investigated for anti-inflammatory properties using topical edema of the mouse ear model (Okoli et al, 2005). The petroleum ether fraction, methanol fraction and methanol extract revealed 65.63, 53.13 and 40.63% inhibition respectively.…”

Section: Antiplasmodial Activitymentioning

confidence: 99%

Securidaca longipedunculata Fresen (Polygalaceae): A review of its ethnomedicinal uses, phytochemistry, pharmacological properties and toxicology

Mongalo

McGaw

Finnie

et al. 2015

Journal of Ethnopharmacology

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Ethnopharmacologicalrelevance: Securidaca longipedunculata Fresen (Polygalaceae) is a multi-purpose plant with a long history of use in African traditional medicine to treat various sexually transmitted infections, hernias, coughs, fever, ascariasis, constipation, headaches, rheumatism, stomach ache, malaria, tuberculosis, pain, epilepsy, pneumonia, skin infections, and it is also used as an aphrodisiac for men. The current paper provides an overview of the present phytochemistry, toxicology, ethnomedicinal uses and pharmacological properties of S. longipedunculata. Materials and methods:The information reported in this paper was collected from a literature search using various computerised databases including ScienceDirect, Moreover, the pharmacokinetic properties of extracts and compounds of the species need to be explored as there is insufficient data available on these aspects.

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“…Plumbago cinsine ait değişik türlerin iltahap ve mikrobiyal hastalıkların tedavisinde kullanıldığı, aynı zamanda taksit etkilerinin olduğu rapor edilmiştir (Arunachalam, Velmurugan, ve Raja 2010). P.europea bitki yapraklarının; kan çıbanı tedavisi, diş ve romatizmal ağrıların giderilmesinde (Okoli, Akah, ve Ezugworie 2006), kök ve kök kabuklarının ise; basur, ishal, cüzzam gibi çeşitli cilt hastalıklarının tedavisinde kullanıldığı bildirilmektedir (Bulut ve Tuzlacı 2011;Uma, Soloman, ve Sharda 1999). Ayrıca, P.europea'nın kaynatıp-süzmek suretiyle hamile kalmak için kullandıkları saptanmıştır (Akan, Korkut, ve Balos 2008).…”

Section: Introductionunclassified

Plumbago europaea L.’ nın Besinsel, Antioksidan ve Antimikrobiyal Aktivitesinin Belirlenmesi

Bircan¹,

Kırbağ²

2015

AÇÜ Orm Fak Derg

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ÖzetBu çalışmada; P. europea'nın besinsel içerikleri, antioksidan ve antimikrobiyal etkileri araştırıldı. Şeker, flavonoid, vitamin ve mineral element düzeylerinin değişebildiği gözlendi. In vitro koşullarda, DPPH radikalini temizleme aktivitesinin 10 µg/µL'de %83.62, FeCl grubunun K grubuna göre yüksek ve metil esterlerinin ise korunmadığı belirlendi. P. europea'nın antimikrobiyal aktivitesinin ise; maya ve dermofit funguslardan ziyade, bakteri gruplarında daha etkili olduğu saptandı.Anahtar kelimeler: Antimikrobiyal aktivite, antioksidan, besinsel içerik, P. europea AbstractIn this study, nutritive value, antioxidant and antimicrobial activitiy of P. europea was determined. It was observed that sugar, flavonoid, vitamin and element levels varied. It was understood that under in vitro conditions the DPPH activities had a level of 83.62% at 10 µg/µL, the FeCL group was higher than the K group, and the methyl esters were not preserved as well. It was also determined that the antimicrobial activity of P. europea is more efficent over bacterial groups then yeast and dermatophyte fungi.

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Anti-inflammatory activity of extracts of root bark of <i>Securidaca longipedunculata</i> fres (polygalaceae)

Cited by 27 publications

References 20 publications

Effect of Securidaca longepedunculata root-bark methanol extract on testicular morphometry of New Zealand rabbits

Effect of Securidaca longepedunculata root-bark methanol extract on testicular morphometry of New Zealand rabbits

Securidaca longipedunculata Fresen (Polygalaceae): A review of its ethnomedicinal uses, phytochemistry, pharmacological properties and toxicology

Plumbago europaea L.’ nın Besinsel, Antioksidan ve Antimikrobiyal Aktivitesinin Belirlenmesi

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