Anti-inflammatory activity of essential oils from<i>Syzygium cumini</i>and<i>Psidium guajava</i>

Siani, Antonio C.; Souza, Mariana C.; Henriques, Maria das Graças; Ramos, Mônica Freiman de Souza

doi:10.3109/13880209.2013.768675

Cited by 69 publications

(51 citation statements)

References 17 publications

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“…Recently, Siani et al . 42 reported that effective inhibition of eosinophil migration by essential oils from Syzygium cumini Skells and Psidium guajava L. correlated with the presence of β-pinene. Because α-pinene was completely inactive in all of our test-systems (Table 3), we suggest that human neutrophils can discriminate between α- and β- isomers of this bicyclic monoterpene.…”

Section: Discussionmentioning

confidence: 99%

Inhibition of Human Neutrophil Responses by the Essential Oil of Artemisia kotuchovii and Its Constituents

Schepetkin

Кушнаренко

Özek

et al. 2015

J. Agric. Food Chem.

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Essential oils were obtained by hydrodistillation of the flowers+leaves and stems of Artemisia kotuchovii Kupr. (AKEOf+l and AKEOstm, respectively) and analyzed by gas chromatography (GC) and gas chromatography-mass spectrometry (GC/MS). The primary components of the oils were estragole, (E)- and (Z)-β-ocimenes, methyl eugenol, limonene, spathulenol, β-pinene, myrcene, and (E)-methyl cinnamate. Seventy four constituents were present at concentrations from 0.1 to 1.0%, and 34 compounds were identified in trace (<0.1%) amounts in one or both plant components. Screening of the essential oils for biological activity showed that AKEOstm, but not AKEOf+l, inhibited N-formyl-Met-Leu-Phe (fMLF)-stimulated Ca2+ flux and chemotaxis and phorbol-12-myristate-13-acetate (PMA)-induced reactive oxygen species (ROS) production in human neutrophils. Selected pure constituents, representing >96% of the AKEOstm composition, were also tested in human neutrophils and HL-60 cells transfected with N-formyl peptide receptor 1 (FPR1). We found that one component, 6-methyl-3,5-heptadien-2-one (MHDO), inhibited fMLF- and interleukin 8 (IL-8)-stimulated Ca2+ flux, fMLF-induced chemotaxis, and PMA-induced ROS production in human neutrophils. MHDO also inhibited fMLF-induced Ca2+ flux in FPR1-HL60 cells. These results suggest that MHDO may be effective in modulating some innate immune responses, possibly by an inhibition of neutrophil migration and ROS production.

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Section: Discussionmentioning

confidence: 99%

Inhibition of Human Neutrophil Responses by the Essential Oil of Artemisia kotuchovii and Its Constituents

Schepetkin

Кушнаренко

Özek

et al. 2015

J. Agric. Food Chem.

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“…Another explanation beside the reduced toxicity due to a reduction of unknown toxic combustion products, might be the antioxidant and radical-scavenging activity of eugenol (Atsumi et al, 2001;Fujisawa et al, 2000Fujisawa et al, , 2002Kadoma et al, 2007). Other components of the oleoresins, especially b-caryophyllene, exhibit the same chemical properties to a significant extent (Chang et al, 2013;Siani et al, 2013).…”

Section: In Vitro Mammalian Cell Cytotoxicitymentioning

confidence: 94%

Toxicological assessment of kretek cigarettes part 4: Mechanistic investigations, smoke chemistry and in vitro toxicity

Roemer

Dempsey

Lawless-Pyne

et al. 2014

Regulatory Toxicology and Pharmacology

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The smoke chemistry and in vitro toxicity of mainstream smoke (MS) was investigated in American-blended cigarettes with or without the addition of 2.5%, 5% or 10% eugenol to the tobacco and in Indonesian-blended cigarettes with and without the addition of cloves, cloves extracted with hot ethanol, and extracted cloves replenished with eugenol or clove oil. The addition of eugenol reduced the concentration of nearly all toxicants measured in MS as well as the in vitro cytotoxicity of the gas/vapor phase. Reductions were also seen in bacterial mutagenicity of the total particulate matter (TPM) assessed by the Ames Assay. The addition of extracted cloves led to increases and decreases of toxicant concentrations in MS. Replenishment with eugenol or clove oil decreased the toxicant concentrations; with most smoke constituent concentrations reduced below the concentration found in tobacco-only cigarettes. Cytotoxicity of the TPM was not affected by the clove preparations. However, GVP cytotoxicity was reduced (untreated cloves showing the highest reductions). Mutagenicity of TPM was decreased by the clove preparations. Mechanisms for the reductions, (up to 40%), are most likely due to dilution effects by eugenol, changed burning characteristics of the tobacco, and free radical scavenging by eugenol.

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“…59 In another study, essential oils from the Jamun leaf inhibited the migration of rat eosinophils, indicating that Jamun leaf possesses anti-inflammatory activity. 60 The aqueous leaf extract has also been reported to reduce indomethacin-induced inflammatory changes in the mice by reducing nitric oxide synthase (iNOS), tumor necrosis factor-alpha (TNF-α) and cyclooxygenase (COX) enzymes. 45 The essential oils from Jamun leaf have been reported to alleviate chronic granulomatous inflammation in BALB/c mice that had been intravenously infected with Mycobacterium bovis Bacillus Calmettte-Guerin.…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

Phytochemical Composition and Pleotropic Pharmacological Properties of Jamun, Syzygium Cumini Skeels

Jagetia¹

2017

Journal of Exploratory Research in Pharmacology

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Plants have been employed as medicine since time immemorial, and there has been a recent resurgence in the use of plants as medicines due to their little or no toxicity at the doses used for treatment of different ailments. This review discusses in detail the phytochemical and pharmacological activities of Jamun (Syzygium cumini), a tree belonging to family Myrtaceae, which has been credited with several medicinal properties in the traditional system of medicine, the Ayurveda. The different properties attributed to Jamun are sweet, sour, astringent, acrid, refrigerant, carminative, diuretic, and digestive. Research and practical use in traditional medicinal systems have found Jamun to be effective in treating leucorrhoea, gastric disorders, fever, diabetes, piles, stomachache, wounds, and dental, digestive and skin disorders. Some compounds in Jamun have antioxidant, antimicrobial, antiallergic, antidiabetic, antihyperlipidemic, anticancer, gastroprotective, hepatoprotective, cardioprotective and radioprotective activity. Finally, Jamun has been found to contain phytochemicals including anthroquinones, alkaloids, catechins, flavonoids, glycosides, steroids, phenols, tannins, saponins and cardiac glycosides. The diverse activities of Jamun may be due to its abilities to scavenge free radicals, increase antioxidant status of cells by increasing glutathione, glutathione peroxidase, catalase and/or superoxide dismutase, and to attenuate lipid peroxidation. In addition, it also suppresses the transcription of peroxisome proliferator-activated receptor, Nuclear factor kappa B, cyclooxygenase, inducible nitric oxide synthase, tumor necrosis factor alpha and other proinflammatory cytokines, accompanied by the up-regulation of nuclear factor erythroid 2-related factor 2 transcription, which is involved in regulating the antioxidant status of the cells.

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Anti-inflammatory activity of essential oils fromSyzygium cuminiandPsidium guajava

Abstract: Essential oils from SC and PG may be useful to treat inflammatory diseases by mechanisms that include the inhibition of eosinophil migration.

Cited by 69 publications

References 17 publications

Inhibition of Human Neutrophil Responses by the Essential Oil of Artemisia kotuchovii and Its Constituents

Inhibition of Human Neutrophil Responses by the Essential Oil of Artemisia kotuchovii and Its Constituents

Toxicological assessment of kretek cigarettes part 4: Mechanistic investigations, smoke chemistry and in vitro toxicity

Phytochemical Composition and Pleotropic Pharmacological Properties of Jamun, Syzygium Cumini Skeels

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