Anti-Inflammatory Activity of Curcumin and Capsaicin Augmented in Combination

Abstract

Objective: Dietary curcumin and capsaicin are well known for their health beneficial potencies. The current study was done to assess the antiinflammatory activity of curcumin, capsaicin and their combination by employing in vitro and in vivo models. Methods:We investigated the protective effect of curcumin, capsaicin and their combination using in vitro heat induced human red blood cell (HRBC) membrane stabilisation, in vivo 3% agar induced leukocyte mobilisation and acetic acid induced vascular permeability assay.Results: Curcumin, capsaicin and their combination exhibited concentration dependent protective effect against heat-induced HRBC membrane destabilisation, while combined curcumin and capsaicin restored (87.0±0.64 %) membrane stability and it is found to be better than curcumin, capsaicin and standard diclofenac sodium (75.0±0.25. 72±0.9 and 80.0±0.31 %) protective effect. In agar suspension induced leukocyte mobilization assay, the combined curcumin and capsaicin had shown 39.5±1.58 % of inhibition compared to individual curcumin and capsaicin, which showed moderate inhibition of 16.0±3.14 and 21.6±2.17 % respectively. Besides, the combined curcumin and capsaicin had shown highly significant inhibition of acetic acid-induced vascular permeability in rats (62.0±3.14 %), whereas individual curcumin and capsaicin showed moderate inhibition of vascular permeability with 36.0±2.41 and 43.0±1.92 % respectively. Conclusion:This study demonstrates the significant anti-inflammatory property of combined curcumin and capsaicin at half of the individual concentration of curcumin and capsaicin.

Influence of Tetracycline on Gram-Negative Strain Klebsiella oxytoca in Mild Steel Corrosion

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“…SEM morphology (Fig. 3) indicates that biofilm forming microorganism may cause corrosion or protective effects on the metal surface [23][24][25]. Through the balanced growth, amide I and amide II band of C-O stretch at 1650, 1540 and 1084 cm -1 is due to the formation of protein films on test coupon as shown in Fig.…”

In vitro assessment on anti-inflammatory and anti-lipidemic properties of selected plant species

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Evaluation of Benzylidene-Acetone Analogues of Curcumin as Antituberculosis

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