Anti-Inflammatory Activity of Constituents Isolated from Ulmus davidiana var. japonica

Zheng, Ming Shan; Yang, Ju-Hye; Li, Ying; Li, Xian; Chang, Hyeun‐Wook; Son, Jong‐Keun

doi:10.4062/biomolther.2010.18.3.321

Cited by 15 publications

(11 citation statements)

References 42 publications

(25 reference statements)

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“…The anti-inflammatory activity of friedelin (2) was reported by the carrageen induced paw edema method (Shimizu and Tomoo, 1994). Although, friedelin (2) was reported to be inactive against 5-LOX dependent LTC 4 formation in bone marrow derived mast cells (Zheng et al, 2010), our results showed that the compound (2) indeed had a stronger inhibition of the SBL enzyme. Sailer et al (1996) reported that pentacyclic triterpenes with keto group were crucial for their inhibition of 5-LOX.…”

Section: Resultscontrasting

confidence: 66%

Lipoxygenase inhibitory activity of crude bark extracts and isolated compounds from Commiphora berryi

Kumari¹,

Arumugam²,

Selvamani³

et al. 2011

Journal of Ethnopharmacology

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Section: Resultscontrasting

confidence: 66%

Lipoxygenase inhibitory activity of crude bark extracts and isolated compounds from Commiphora berryi

Kumari¹,

Arumugam²,

Selvamani³

et al. 2011

Journal of Ethnopharmacology

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“…In fact, while phenolic compounds are generally described as prominent plant-derived inhibitors of 5-LOX product synthesis [28,30], individual constituents identified in stem bark extract can directly contribute to the observed inhibitory effects. Specifically concerning monomeric flavan-3-ols, it is worth referring to the effects upon 5-LOX dependent leukotriene C 4 (LTC 4 ) production in bone marrow-derived mast cells upon treatment with catechin ( 2 ) (20 µM), mediating 99.8% inhibition [31], being also reported to inhibit potato 5-LOX activity (IC 50 value of 16.5 µg/mL) [32]. Relevantly, catechin ( 2 ) happens to be one of the main active compounds found in flavocoxid, an FDA-approved medical food for the treatment of osteoarthritis [33].…”

Section: Discussionmentioning

confidence: 99%

Phenolic Profiling and Biological Potential of Ficus curtipes Corner Leaves and Stem Bark: 5-Lipoxygenase Inhibition and Interference with NO Levels in LPS-Stimulated RAW 264.7 Macrophages

et al. 2019

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The economic value of fig trees has been globally acknowledged due to their utilization in the food industry, being also frequently used in traditional medicine. While ubiquitously distributed in Southeast Asia, Ficus curtipes Corner remains uninvestigated concerning its biological properties and chemical profile. HPLC-DAD-ESI/MSn characterization of methanol extracts obtained from the stem bark and leaves allowed the identification and quantitation of 21 phenolic compounds for the first time; the stem bark was predominantly rich in flavan-3-ols and apigenin derivatives, while solely apigenin-di-glycosides have been identified and quantitated on the leaf extract. Both extracts inhibited 5-lipoxygenase (5-LOX) activity in a concentration-dependent manner, the one obtained from the stem bark being significantly more active (IC50 = 10.75 μg/mL). The effect of both extracts on lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages was evaluated, and while the stem bark extract did not lead to a noticeable interference on nitric oxide (NO) levels, the extract obtained from the leaves notably decreased NO and L-citrulline levels at concentrations ranging from 250 to 500 μg/mL. Herein, F. curtipes is valorized due to its modulatory effects on inflammatory mediators and also as a source of bioactive phenols, which may fuel further studies on the development of nutraceuticals.

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“…Detailed studies on chemical characterization demonstrated polyphenolic catechins as major bioactives of the RUE [ 16 , 42 , 43 ]. Accordingly, we analyzed the eight major catechins in the RUE using HPLC and LC/MS ( S1 Fig ), and we could detect only catechin that is reported as one of major bioactive antioxidant compounds in the RUE [ 16 , 42 , 43 ]. In addition, the catechin compound has been reported as a bioactive compound with antioxidant effect and thus protective against alcohol-induced liver injury in rats through suppression of ROS-mediated NF-kB signaling pathways [ 44 ].…”

Section: Discussionmentioning

confidence: 99%

Root bark of Ulmus davidiana var. japonica restrains acute alcohol-induced hepatic steatosis onset in mice by inhibiting ROS accumulation

et al. 2017

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Alcohol-induced hepatic steatosis and inflammation are key drivers of alcohol-induced liver injury, mainly caused by oxidative stress. The roots bark of Ulmus davidiana var. japonica is well known for its substantial antioxidative and antitumorigenic potency. In this study, we examined whether this plant can ameliorate alcohol-induced liver injuries characterized by hepatic steatosis and inflammation through its antioxidative activity. C57BL/6J mice were treated with the root bark extract of Ulmus davidiana var. japonica (RUE; 100 mg of extract/kg bodyweight; oral gavage) and alcohol (1 g/kg of bodyweight; oral gavage) for 5 days. Markers of acute alcohol-induced hepatic steatosis were determined and putative molecular mechanisms responsible for the protection of RUE were investigated. RUE noticeably protected against alcohol-induced hepatic steatosis and inflammation. Reactive oxygen species (ROS), over-produced by alcohol, negatively orchestrated various signaling pathways involved in the lipid metabolism and inflammation. These pathways were restored through the ROS scavenging activity of RUE in the liver. In particular, the expression of lipogenic genes (e.g., SREBP-1, ACC, and FAS) and inflammatory cytokines (e.g., IL-1β, and NF-κB p65) significantly decreased with RUE treatment. Conversely, the expression of fatty acid oxidation-related genes (e.g., SIRT1, AMPKα, and PGC1α) were increased in mice treated with RUE. Thus, the results indicate that RUE counteracts and thus attenuates alcoholic hepatic steatosis onset in mice, possibly by suppressing ROS-mediated steatosis and inflammation.

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Anti-Inflammatory Activity of Constituents Isolated from Ulmus davidiana var. japonica

Cited by 15 publications

References 42 publications

Lipoxygenase inhibitory activity of crude bark extracts and isolated compounds from Commiphora berryi

Lipoxygenase inhibitory activity of crude bark extracts and isolated compounds from Commiphora berryi

Phenolic Profiling and Biological Potential of Ficus curtipes Corner Leaves and Stem Bark: 5-Lipoxygenase Inhibition and Interference with NO Levels in LPS-Stimulated RAW 264.7 Macrophages

Root bark of Ulmus davidiana var. japonica restrains acute alcohol-induced hepatic steatosis onset in mice by inhibiting ROS accumulation

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